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- W4307309462 abstract "Abstract The causality of the association between depression and gastrointestinal diseases is undetermined. We conducted a Mendelian randomization (MR) investigation to systematically explore the associations of depression with 24 gastrointestinal diseases. Independent genetic variants associated with depression at the genome-wide significance level were selected as instrumental variables. Genetic associations with 24 gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analysis was conducted to explore the mediation effects of body mass index, cigarette smoking, and type 2 diabetes. After multiple-testing corrections, genetic liability to depression was associated with increased risk of irritable bowel syndrome, non-alcohol fatty liver disease, alcoholic liver disease, gastroesophageal reflux, chronic pancreatitis, duodenal ulcer, chronic gastritis, gastric ulcer, diverticular disease, cholelithiasis, acute pancreatitis, and ulcerative colitis. The associations of genetic liability to depression with non-alcoholic fatty liver disease was largely mediated by body mass index. Genetic liability to smoking initiation mediated half of association of depression with acute pancreatitis. This MR investigation suggests that depression may have a causal role in the development of several gastrointestinal diseases." @default.
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- W4307309462 date "2022-10-26" @default.
- W4307309462 modified "2023-10-01" @default.
- W4307309462 title "Depression and 24 Gastrointestinal Diseases: A Mendelian Randomization Study" @default.
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- W4307309462 doi "https://doi.org/10.21203/rs.3.rs-2165303/v1" @default.
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