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- W4307331301 abstract "Most tumors are characterized by increased glucose uptake and lactate production, a phenomenon known as aerobic glycolysis. Active glucose uptake and glycolysis can provide the synthesis of basic metabolites required for proliferation. The final step in aerobic glycolysis is the NADH-dependent reduction of pyruvate to lactate with the participation of lactate dehydrogenase (LDH) [1-5]. It has been shown that inhibition of LDH activity can reduce lactate production, slow down the growth of tumor cells in vitro and in vivo modulation of immune responses [6-10], but there are practically no studies elucidating the role of LDH in tumor dissemination." @default.
- W4307331301 created "2022-10-31" @default.
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- W4307331301 date "2022-10-14" @default.
- W4307331301 modified "2023-09-26" @default.
- W4307331301 title "INHIBITION OF LACTATE DEHYDROGENASE REDUCES THE SURVIVAL OF METASTATICALLY ACTIVE LEWIS LUNG CARCINOMA CELLS" @default.
- W4307331301 doi "https://doi.org/10.36074/logos-14.10.2022.11" @default.
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