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• W4307337219 startingPage "159101992211352" @default.
• W4307337219 abstract "Early neurological deterioration (END) is a potential predictor for 90-day outcomes following mechanical thrombectomy for acute ischemic stroke (AIS). We performed a systematic review and meta-analysis to better understand whether END can be used as a surrogate for long-term outcomes.Following the PRISMA guidelines, a systematic literature review of the English language literature was conducted using PubMed, MEDLINE, and Embase. END definition was cataloged for each included study. Outcomes of interest included 90-day modified Rankin Scale (mRS) 0-2, symptomatic intracranial hemorrhage (sICH), mortality, and thrombolysis in cerebral infarction (TICI) 2b-3. We calculated pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CI) for all definitions of END.We included seven studies with 2992 patients in our analysis. There was a significant, inverse association with END and mRS 0-2 rates (OR = 0.15; 95% CI = 0.08-0.29; P-value< 0.001). Moreover, END was a significant predictor of increased odds for reported sICH rates (OR = 16.37; 95% CI = 7.66-34.99; P-value< 0.001). Furthermore, there was a significant association between END and increase in mortality rates (OR = 6.79; 95% CI = 2.62-17.62; P-value< 0.001). There was no significant association between END and rates of TICI 2b-3 (OR = 0.53; 95% CI = 0.27-1.05; p = 0.069).Broadly defined, END holds value as a potential predictor of rates of mRS 0-2 at 90 days and is associated with higher rates of mortality and sICH, but had no correlation with TICI 2b-3." @default.
• W4307337219 created "2022-10-31" @default.
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• W4307337219 date "2022-10-26" @default.
• W4307337219 modified "2023-10-06" @default.
• W4307337219 title "Early neurological deterioration as a predictor of outcomes after endovascular thrombectomy for stroke: A systematic review and meta-analysis" @default.
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• W4307337219 doi "https://doi.org/10.1177/15910199221135289" @default.
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