Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307338558> ?p ?o ?g. }
- W4307338558 abstract "G-quadruplexes (G4s), secondary structures adopted by guanine-rich DNA and RNA sequences, are implicated in numerous biological processes and have been suggested as potential drug targets. Accordingly, there is an increasing interest in developing high-throughput methods that allow the generation of congeneric series of G4-targeting molecules (ligands) and investigating their interactions with the targets. We have developed an operationally simple method of parallel synthesis to generate ready-to-screen libraries of cationic acylhydrazones, a motif that we have previously identified as a promising scaffold for potent, biologically active G4 ligands. Combined with well-established screening techniques, such as fluorescence melting, this method enables the rapid synthesis and screening of combinatorial libraries of potential G4 ligands. Following this protocol, we synthesized a combinatorial library of 90 bis(acylhydrazones) and screened it against five different nucleic acid structures. This way, we were able to analyze the structure-activity relationships within this series of G4 ligands, and identified three novel promising ligands whose interactions with G4-DNAs of different topologies were studied in detail by a combination of several biophysical techniques, including native mass spectrometry, and molecular modeling." @default.
- W4307338558 created "2022-10-31" @default.
- W4307338558 creator A5000390428 @default.
- W4307338558 creator A5013458899 @default.
- W4307338558 creator A5022347911 @default.
- W4307338558 creator A5032046128 @default.
- W4307338558 creator A5047309952 @default.
- W4307338558 creator A5076596128 @default.
- W4307338558 date "2022-11-30" @default.
- W4307338558 modified "2023-10-14" @default.
- W4307338558 title "Optimization of G‐Quadruplex Ligands through a SAR Study Combining Parallel Synthesis and Screening of Cationic Bis(acylhydrazones)" @default.
- W4307338558 cites W1450574606 @default.
- W4307338558 cites W1765730586 @default.
- W4307338558 cites W1976609463 @default.
- W4307338558 cites W1983111514 @default.
- W4307338558 cites W1984376253 @default.
- W4307338558 cites W1985588649 @default.
- W4307338558 cites W1991580414 @default.
- W4307338558 cites W1996639070 @default.
- W4307338558 cites W2008182786 @default.
- W4307338558 cites W2009423060 @default.
- W4307338558 cites W2015598957 @default.
- W4307338558 cites W2018104916 @default.
- W4307338558 cites W2027657574 @default.
- W4307338558 cites W2037144426 @default.
- W4307338558 cites W2041626076 @default.
- W4307338558 cites W2053335198 @default.
- W4307338558 cites W2062064818 @default.
- W4307338558 cites W2068987819 @default.
- W4307338558 cites W2074613554 @default.
- W4307338558 cites W2078324880 @default.
- W4307338558 cites W2099465074 @default.
- W4307338558 cites W2103781141 @default.
- W4307338558 cites W2113059992 @default.
- W4307338558 cites W2113364934 @default.
- W4307338558 cites W2117768735 @default.
- W4307338558 cites W2132629607 @default.
- W4307338558 cites W2140590042 @default.
- W4307338558 cites W2143920992 @default.
- W4307338558 cites W2146805637 @default.
- W4307338558 cites W2320936920 @default.
- W4307338558 cites W2323449394 @default.
- W4307338558 cites W2402946260 @default.
- W4307338558 cites W2537246643 @default.
- W4307338558 cites W2557849941 @default.
- W4307338558 cites W2575927822 @default.
- W4307338558 cites W2588267243 @default.
- W4307338558 cites W2594536071 @default.
- W4307338558 cites W2604527271 @default.
- W4307338558 cites W2612060709 @default.
- W4307338558 cites W2725779950 @default.
- W4307338558 cites W2768999743 @default.
- W4307338558 cites W2780677469 @default.
- W4307338558 cites W2788112840 @default.
- W4307338558 cites W2788513881 @default.
- W4307338558 cites W2796034874 @default.
- W4307338558 cites W2801097588 @default.
- W4307338558 cites W2805876309 @default.
- W4307338558 cites W2858890923 @default.
- W4307338558 cites W2883883147 @default.
- W4307338558 cites W2884212977 @default.
- W4307338558 cites W2890331704 @default.
- W4307338558 cites W2896637864 @default.
- W4307338558 cites W2898240189 @default.
- W4307338558 cites W2914439463 @default.
- W4307338558 cites W2945550327 @default.
- W4307338558 cites W2947392804 @default.
- W4307338558 cites W2954390038 @default.
- W4307338558 cites W2966334511 @default.
- W4307338558 cites W2999471275 @default.
- W4307338558 cites W3002859220 @default.
- W4307338558 cites W3005290005 @default.
- W4307338558 cites W3006208937 @default.
- W4307338558 cites W3010432254 @default.
- W4307338558 cites W3010917174 @default.
- W4307338558 cites W3039093461 @default.
- W4307338558 cites W3111563555 @default.
- W4307338558 cites W3119152526 @default.
- W4307338558 cites W3122032999 @default.
- W4307338558 cites W3127117064 @default.
- W4307338558 cites W3128212187 @default.
- W4307338558 cites W3181567073 @default.
- W4307338558 cites W3212326044 @default.
- W4307338558 cites W3212632124 @default.
- W4307338558 cites W4200523478 @default.
- W4307338558 cites W4206881430 @default.
- W4307338558 cites W4229442717 @default.
- W4307338558 cites W4251061998 @default.
- W4307338558 cites W4253064423 @default.
- W4307338558 cites W4281390289 @default.
- W4307338558 cites W4283363468 @default.
- W4307338558 cites W4290667683 @default.
- W4307338558 cites W4292604372 @default.
- W4307338558 cites W4307338558 @default.
- W4307338558 cites W807744939 @default.
- W4307338558 doi "https://doi.org/10.1002/chem.202202427" @default.
- W4307338558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36286608" @default.
- W4307338558 hasPublicationYear "2022" @default.
- W4307338558 type Work @default.
- W4307338558 citedByCount "1" @default.