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- W4307347545 abstract "Pharmacogenomics (PGx) is a scientific discipline that has evolved over a period of 50 years parallel to DNA sequencing and molecular technology, unraveling the truth behind the influence of genes on drug outcomes. It uses the understanding and in-depth knowledge of pharmacology clubbed with genomic data to individualize/personalize drug treatment and successfully implement the paradigm “right drug to right patient at right dose” by limiting adverse drug events and enhancing drug efficacy. Consequently, the application of PGx-based therapies will overcome the burden of the trial-and-error method of traditional drug prescription, thereby reducing the time spent in the treatment, and helps in improving the prognosis of the disease. Furthermore, validation of PGx helps minimize the time spent and the financial burden implicated during the clinical trials of the new drug development process. Currently, several validated examples exist that can substantiate the significance of PGx application in clinical practice. Despite such significant advancements in the field of PGx, several challenges prevail, and the ethical elements and clinical guidelines essential for PGx utilization and implementation in clinical practice are still in the phase of dormancy. This chapter provides a comprehensive overview pertaining to the current existing literature on pharmacogenomics that will aid in augmenting the existing knowledge, and decision making of healthcare professionals toward individualized drug therapy." @default.
- W4307347545 created "2022-10-31" @default.
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- W4307347545 date "2022-10-26" @default.
- W4307347545 modified "2023-10-16" @default.
- W4307347545 title "Clinical Relevance of Pharmacogenomics – a Road to Personalized Medicine" @default.
- W4307347545 doi "https://doi.org/10.1201/9781003246244-2" @default.
- W4307347545 hasPublicationYear "2022" @default.
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