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- W4307348290 abstract "Autophagy is a fundamental catabolic process coordinated by a network of autophagy-related (ATG) proteins. These ATG proteins also perform an important parallel role in noncanonical autophagy, a lysosome-associated signaling pathway with key functions in immunity, inflammation, cancer, and neurodegeneration. While the noncanonical autophagy pathway shares the common ATG machinery, it bears key mechanistic and functional distinctions, and is characterized by conjugation of ATG8 to single membranes (CASM). Here, we review the diverse, and still expanding, collection of stimuli and processes now known to harness the noncanonical autophagy pathway, including engulfment processes, drug treatments, TRPML1 and STING signaling, viral infection, and other pathogenic factors. We discuss the multiple associated routes to CASM and assess their shared and distinctive molecular features. By integrating these findings, we propose an updated and unifying mechanism for noncanonical autophagy, centered on ATG16L1 and V-ATPase." @default.
- W4307348290 created "2022-10-31" @default.
- W4307348290 creator A5033694495 @default.
- W4307348290 creator A5036154714 @default.
- W4307348290 date "2022-10-28" @default.
- W4307348290 modified "2023-10-14" @default.
- W4307348290 title "Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism" @default.
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