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- W4307362947 endingPage "216" @default.
- W4307362947 startingPage "199" @default.
- W4307362947 abstract "Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal brain tissue within which the recurrence is expected to appear in the majority of cases. Thus, in the last decades, an increased interest has developed to investigate the cellular and molecular interactions between GBM and the peritumoral brain zone (PBZ) bordering the tumor tissue. The aim of this review is to provide up-to-date knowledge about the oncogenic properties of the PBZ to highlight possible druggable targets for more effective treatment of GBM by limiting the formation of recurrence, which is almost inevitable in the majority of patients. Starting from the description of the cellular components, passing through the illustration of the molecular profiles, we finally focused on more clinical aspects, represented by imaging and radiological details. The complete picture that emerges from this review could provide new input for future investigations aimed at identifying new effective strategies to eradicate this still incurable tumor." @default.
- W4307362947 created "2022-10-31" @default.
- W4307362947 creator A5015034109 @default.
- W4307362947 creator A5018363058 @default.
- W4307362947 creator A5019801772 @default.
- W4307362947 creator A5036746185 @default.
- W4307362947 creator A5037254016 @default.
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- W4307362947 creator A5053824564 @default.
- W4307362947 creator A5087063740 @default.
- W4307362947 creator A5091376976 @default.
- W4307362947 date "2022-10-27" @default.
- W4307362947 modified "2023-10-14" @default.
- W4307362947 title "The peritumoral brain zone in glioblastoma: where we are and where we are going" @default.
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