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- W4307367088 abstract "Background: Quinacrine (QC), an attractive anticancer drug , has been forwarded for clinical evaluation in various cancer types due to its tremendous safety data accumulated since World War II . Its shotgun nature makes it unmissable as a chemotherapy drug that traps and activates multiple pathways. Results: Recently, QC has been shown to block malignancy by affecting pathways, including RHO signaling, G1/S arrest, ROS emission, and cell death, and ,,, through autophagy. In this review, we have extensively studied QC as an anticancer agent that affect various signaling pathways. We have documented activity via WNT, NOTCH, HEDGEHOG, MAPK, EGFR, P53, RHO, AKT, NF-k and TGF pathways and reformed the already established mode of action of QC. Conclusion: QC’s effects on multiple key signaling pathways, implicated in the malignant progression of numerous cancer types, make it an exciting candidate as a chemotherapeutic agent for new combination treatments and therapies." @default.
- W4307367088 created "2022-10-31" @default.
- W4307367088 creator A5045140204 @default.
- W4307367088 date "2022-09-25" @default.
- W4307367088 modified "2023-09-25" @default.
- W4307367088 title "Fighting New Wars with old Weapons: Repurposing of Anti-Malarial Drug for Anticancer Therapy" @default.
- W4307367088 doi "https://doi.org/10.32768/abc.202294439-449" @default.
- W4307367088 hasPublicationYear "2022" @default.
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