Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307373407> ?p ?o ?g. }
- W4307373407 abstract "The integrity of skin tissue structure and function plays an important role in maintaining skin rejuvenation. Ultraviolet (UV) radiation is the main environmental factor that causes skin aging through photodamage of the skin tissue. Cryptotanshinone (CTS), an active ingredient mianly derived from the Salvia plants of Lamiaceae, has many pharmacological effects, such as anti-inflammatory, antioxidant, and anti-tumor effects. In this study, we showed that CTS could ameliorate the photodamage induced by UV radiation in epidermal keratinocytes (HaCaT) and dermal fibroblasts (HFF-1) when applied to the cells before exposure to the radiation, effectively delaying the aging of the cells. CTS exerted its antiaging effect by reducing the level of reactive oxygen species (ROS) in the cells, attenuating DNA damage, activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway, and reduced mitochondrial dysfunction as well as inhibiting apoptosis. Further, CTS could promote mitochondrial biosynthesis in skin cells by activating the AMP-activated protein kinase (AMPK)/sirtuin-1 (SIRT1)/peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) signaling pathway. These findings demonstrated the protective effects of CTS against UV radiation-induced skin photoaging and provided a theoretical and experimental basis for the application of CTS as an anti-photodamage and anti-aging agent for the skin." @default.
- W4307373407 created "2022-11-01" @default.
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- W4307373407 date "2022-10-25" @default.
- W4307373407 modified "2023-10-18" @default.
- W4307373407 title "Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis" @default.
- W4307373407 cites W1532316600 @default.
- W4307373407 cites W1587130504 @default.
- W4307373407 cites W1966558304 @default.
- W4307373407 cites W1968408636 @default.
- W4307373407 cites W1969843775 @default.
- W4307373407 cites W1970924670 @default.
- W4307373407 cites W1972734996 @default.
- W4307373407 cites W1974891950 @default.
- W4307373407 cites W1983594275 @default.
- W4307373407 cites W1986200352 @default.
- W4307373407 cites W1986729183 @default.
- W4307373407 cites W1987711303 @default.
- W4307373407 cites W1988760590 @default.
- W4307373407 cites W1994972521 @default.
- W4307373407 cites W1995354282 @default.
- W4307373407 cites W2002393930 @default.
- W4307373407 cites W2008820810 @default.
- W4307373407 cites W2010720463 @default.
- W4307373407 cites W2013403313 @default.
- W4307373407 cites W2020458523 @default.
- W4307373407 cites W2023714210 @default.
- W4307373407 cites W2024962882 @default.
- W4307373407 cites W2027328852 @default.
- W4307373407 cites W2030386915 @default.
- W4307373407 cites W2030513956 @default.
- W4307373407 cites W2036411709 @default.
- W4307373407 cites W2037681885 @default.
- W4307373407 cites W2043658854 @default.
- W4307373407 cites W2044004625 @default.
- W4307373407 cites W2044213662 @default.
- W4307373407 cites W2067360931 @default.
- W4307373407 cites W2082341355 @default.
- W4307373407 cites W2098264495 @default.
- W4307373407 cites W2104750008 @default.
- W4307373407 cites W2107708548 @default.
- W4307373407 cites W2114349736 @default.
- W4307373407 cites W2114416030 @default.
- W4307373407 cites W2117959552 @default.
- W4307373407 cites W2122538059 @default.
- W4307373407 cites W2123454317 @default.
- W4307373407 cites W2127264357 @default.
- W4307373407 cites W2133444149 @default.
- W4307373407 cites W2136466466 @default.
- W4307373407 cites W2138532261 @default.
- W4307373407 cites W2138631058 @default.
- W4307373407 cites W2139780766 @default.
- W4307373407 cites W2139975555 @default.
- W4307373407 cites W2140549234 @default.
- W4307373407 cites W2150230431 @default.
- W4307373407 cites W2154066769 @default.
- W4307373407 cites W2161220011 @default.
- W4307373407 cites W2163710830 @default.
- W4307373407 cites W2167340008 @default.
- W4307373407 cites W2180909681 @default.
- W4307373407 cites W2184995059 @default.
- W4307373407 cites W2191690548 @default.
- W4307373407 cites W2191745121 @default.
- W4307373407 cites W2231750274 @default.
- W4307373407 cites W2293596122 @default.
- W4307373407 cites W2298276403 @default.
- W4307373407 cites W2306419939 @default.
- W4307373407 cites W2345614571 @default.
- W4307373407 cites W2390143472 @default.
- W4307373407 cites W2398909362 @default.
- W4307373407 cites W2466124354 @default.
- W4307373407 cites W2502726215 @default.
- W4307373407 cites W2575251903 @default.
- W4307373407 cites W2585870619 @default.
- W4307373407 cites W2609008020 @default.
- W4307373407 cites W2619546258 @default.
- W4307373407 cites W2767684630 @default.
- W4307373407 cites W2770827301 @default.
- W4307373407 cites W2790187841 @default.
- W4307373407 cites W2794848018 @default.
- W4307373407 cites W2810322462 @default.
- W4307373407 cites W2810355876 @default.
- W4307373407 cites W2810861436 @default.
- W4307373407 cites W2888547492 @default.
- W4307373407 cites W2893564420 @default.
- W4307373407 cites W2894471006 @default.
- W4307373407 cites W2898573631 @default.
- W4307373407 cites W2900827570 @default.
- W4307373407 cites W2907285117 @default.
- W4307373407 cites W2966352548 @default.