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• W4307425587 endingPage "108922" @default.
• W4307425587 startingPage "108922" @default.
• W4307425587 abstract "Pentylenetetrazol (PTZ) blocks the inhibitory action of GABA, triggering a Glu-mediated hyperexcitation of the dendritic spines in hippocampal CA1 pyramidal neurons that leads to the generation of epileptiform seizures. The aim of this work was to determine the effect of PTZ on the electrical activity of the hippocampal pyramidal neurons in male rats. Bipolar electrodes were implanted stereotaxically in the right and left hippocampal CA1 fields of adults, and PTZ (65 mg/kg) was administered i.p. Simultaneous recordings of the field activity and the firing rate (multiunitary activity, MUA) were analyzed at 10, 20, and 30 min post-administration of PTZ. Only rats that presented tonic-clonic seizures during the first 1-5 min after PTZ treatment were included in the study. The recordings of the field activity were analyzed in 4 frequency bands. In both the right and left hippocampal CA1 fields, the relative power corresponding to the slow waves (4-7 Hz) increased, while in the bands 13-30 Hz and 31-50 Hz, it decreased at 10, 20, and 30 min post-PTZ. MUA recordings were analyzed at four levels. The highest levels corresponded to larger amplitudes of the action potentials in the pyramidal neurons. The firing rates of the PTZ-treated rats did not differ from baseline but presented a significant decrement at 10, 20, and 30 min post-PTZ. The decreased firing rate of the hippocampal CA1 pyramidal neurons after PTZ treatment could be associated with plastic changes of dendritic spines along with some microenvironmental adaptations at synaptic level, after neuronal PTZ-mediated hyperexcitation." @default.
• W4307425587 created "2022-11-01" @default.
• W4307425587 creator A5013721445 @default.
• W4307425587 creator A5050568766 @default.
• W4307425587 creator A5065535018 @default.
• W4307425587 creator A5081890056 @default.
• W4307425587 date "2022-12-01" @default.
• W4307425587 modified "2023-09-25" @default.
• W4307425587 title "Pentylenetetrazol-induced seizures are followed by a reduction in the multiunitary activity of hippocampal CA1 pyramidal neurons in adult rats" @default.
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• W4307425587 doi "https://doi.org/10.1016/j.yebeh.2022.108922" @default.
• W4307425587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36279807" @default.
• W4307425587 hasPublicationYear "2022" @default.
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• W4307425587 hasAuthorship W4307425587A5013721445 @default.
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• W4307425587 hasAuthorship W4307425587A5065535018 @default.

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