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- W4307431332 abstract "Mounting evidence has suggested that phase separation, and especially liquid-liquid phase separation (LLPS), underlies the formation of membraneless organelles, which are supramolecular assemblies of proteins and RNA molecules in cells. These membraneless organelles are also called biomolecular condensates. Evidence is now growing that condensates, such as stress granules, P bodies, Cajal bodies, and nucleoli, play vital roles in biological processes, like RNA storage and processing, signaling regulation, transcription regulation, gene regulation, and transport. Conversely, condensates may cause diseases, such as neurodegenerative diseases and tumors, when they go wrong. Condensates initially have liquid-like properties, but accumulating biological and chemical mutations with age render them into a more solid-like state, like amyloids in Alzheimer's disease, Huntington's disease, and Parkinson's disease. Research into phase separation is still in its infancy, but this field is a promising avenue for treatment of aging-related diseases." @default.
- W4307431332 created "2022-11-01" @default.
- W4307431332 creator A5077960542 @default.
- W4307431332 date "2022-10-31" @default.
- W4307431332 modified "2023-09-24" @default.
- W4307431332 title "Liquid-liquid phase separation: A new perspective to understanding aging and pathogenesis" @default.
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- W4307431332 doi "https://doi.org/10.5582/bst.2022.01453" @default.
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