Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307444503> ?p ?o ?g. }
- W4307444503 abstract "Abstract Background Myelodysplastic syndrome (MDS) is a clonal disease of hematopoietic cells, characterized by hematopoietic cell hematopoiesis and a high risk of transformation into acute myeloid leukemia (AML). Although the underlying mechanism is unclear, MDS is often associated with immune system disorders, especially cellular immune abnormalities. We analyzed the number of lymphocyte subsets by flow cytometry assay and explored the alteration of lymphocyte subsets in MDS. Methods Healthy controls, inpatients with primary MDS and patients with AML diagnosed from January 2017 to July 2021 were included. Flow cytometry assays were used to study lymphocyte subsets obtained from the bone marrow of the participants as well as changes in natural killer (NK) cell function. One-way analysis of variance and Student’s t-test were used to analyze the data. Results We found a reduction in the number and function of NK cells in patients with MDS. By further measuring the activating and inhibitory receptors on the surface of NK cells, we found that the T cell immunoglobulin and ITIM domain (TIGIT) was the highest expressed marker on NK cells. Additionally, the expression of CD155, which is the ligand of TIGIT, was significantly higher than expressions of CD112 and CD113 on bone marrow mesenchymal stem cells (BMSCs). Conclusions The co-culture results of BMSCs and NK cells demonstrated that BMSCs regulate NK cells through the TIGIT/CD155 interaction, indicating that NK cells play a vital role in MDS progression. BMSCs regulate the function of NK cells via TIGIT/CD155." @default.
- W4307444503 created "2022-11-01" @default.
- W4307444503 creator A5006835198 @default.
- W4307444503 creator A5033583174 @default.
- W4307444503 creator A5034607396 @default.
- W4307444503 creator A5042886775 @default.
- W4307444503 creator A5044301848 @default.
- W4307444503 creator A5058896142 @default.
- W4307444503 creator A5059955952 @default.
- W4307444503 creator A5068803178 @default.
- W4307444503 creator A5090798126 @default.
- W4307444503 date "2022-10-27" @default.
- W4307444503 modified "2023-10-14" @default.
- W4307444503 title "Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes" @default.
- W4307444503 cites W1960942182 @default.
- W4307444503 cites W1979144446 @default.
- W4307444503 cites W1980292257 @default.
- W4307444503 cites W1985540837 @default.
- W4307444503 cites W1994748539 @default.
- W4307444503 cites W2004480770 @default.
- W4307444503 cites W2006829631 @default.
- W4307444503 cites W2007825988 @default.
- W4307444503 cites W2009489603 @default.
- W4307444503 cites W2009547749 @default.
- W4307444503 cites W2024971445 @default.
- W4307444503 cites W2031185707 @default.
- W4307444503 cites W2041044681 @default.
- W4307444503 cites W2046409157 @default.
- W4307444503 cites W2050457398 @default.
- W4307444503 cites W2056415390 @default.
- W4307444503 cites W2064919073 @default.
- W4307444503 cites W2075058401 @default.
- W4307444503 cites W2081118119 @default.
- W4307444503 cites W2081484203 @default.
- W4307444503 cites W2086402200 @default.
- W4307444503 cites W2136033583 @default.
- W4307444503 cites W2136976836 @default.
- W4307444503 cites W2142594520 @default.
- W4307444503 cites W2155937296 @default.
- W4307444503 cites W2157155777 @default.
- W4307444503 cites W2171709048 @default.
- W4307444503 cites W2187641303 @default.
- W4307444503 cites W2337861353 @default.
- W4307444503 cites W2488675566 @default.
- W4307444503 cites W2517076746 @default.
- W4307444503 cites W2534828940 @default.
- W4307444503 cites W2554720203 @default.
- W4307444503 cites W2620343734 @default.
- W4307444503 cites W2626558431 @default.
- W4307444503 cites W2808601843 @default.
- W4307444503 cites W2949403516 @default.
- W4307444503 cites W2987385271 @default.
- W4307444503 cites W3010225699 @default.
- W4307444503 cites W3193127644 @default.
- W4307444503 cites W4211164334 @default.
- W4307444503 cites W4231044436 @default.
- W4307444503 doi "https://doi.org/10.1186/s12964-022-00985-2" @default.
- W4307444503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36303184" @default.
- W4307444503 hasPublicationYear "2022" @default.
- W4307444503 type Work @default.
- W4307444503 citedByCount "1" @default.
- W4307444503 countsByYear W43074445032023 @default.
- W4307444503 crossrefType "journal-article" @default.
- W4307444503 hasAuthorship W4307444503A5006835198 @default.
- W4307444503 hasAuthorship W4307444503A5033583174 @default.
- W4307444503 hasAuthorship W4307444503A5034607396 @default.
- W4307444503 hasAuthorship W4307444503A5042886775 @default.
- W4307444503 hasAuthorship W4307444503A5044301848 @default.
- W4307444503 hasAuthorship W4307444503A5058896142 @default.
- W4307444503 hasAuthorship W4307444503A5059955952 @default.
- W4307444503 hasAuthorship W4307444503A5068803178 @default.
- W4307444503 hasAuthorship W4307444503A5090798126 @default.
- W4307444503 hasBestOaLocation W43074445031 @default.
- W4307444503 hasConcept C109159458 @default.
- W4307444503 hasConcept C198826908 @default.
- W4307444503 hasConcept C203014093 @default.
- W4307444503 hasConcept C2776090121 @default.
- W4307444503 hasConcept C2779118045 @default.
- W4307444503 hasConcept C2779282312 @default.
- W4307444503 hasConcept C2780007613 @default.
- W4307444503 hasConcept C28328180 @default.
- W4307444503 hasConcept C502942594 @default.
- W4307444503 hasConcept C553184892 @default.
- W4307444503 hasConcept C71924100 @default.
- W4307444503 hasConcept C86803240 @default.
- W4307444503 hasConcept C8891405 @default.
- W4307444503 hasConcept C95444343 @default.
- W4307444503 hasConceptScore W4307444503C109159458 @default.
- W4307444503 hasConceptScore W4307444503C198826908 @default.
- W4307444503 hasConceptScore W4307444503C203014093 @default.
- W4307444503 hasConceptScore W4307444503C2776090121 @default.
- W4307444503 hasConceptScore W4307444503C2779118045 @default.
- W4307444503 hasConceptScore W4307444503C2779282312 @default.
- W4307444503 hasConceptScore W4307444503C2780007613 @default.
- W4307444503 hasConceptScore W4307444503C28328180 @default.
- W4307444503 hasConceptScore W4307444503C502942594 @default.
- W4307444503 hasConceptScore W4307444503C553184892 @default.
- W4307444503 hasConceptScore W4307444503C71924100 @default.
- W4307444503 hasConceptScore W4307444503C86803240 @default.
- W4307444503 hasConceptScore W4307444503C8891405 @default.