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- W4307454588 endingPage "111810" @default.
- W4307454588 startingPage "111810" @default.
- W4307454588 abstract "Obesity is a modern pandemic with negative consequences in women's reproductive health. Women with overweight and obesity can develop mammary gland alterations that unable exclusive breastfeeding. Obesity associates with a disturbed lactating mammary gland endocrine environment including a decreased action of the hormone prolactin (PRL), the master regulator of lactation. The PRL receptor and the action of PRL are reduced in the mammary gland of lactating rodents fed an obesogenic diet and are contributing factors to impaired lactation in obesity. Also, treatment with PRL improves milk yield in women with lactation insufficiency. This review focuses on the impact of diet-induced obesity in the lactating mammary gland and how obesity impairs the lactogenic action of PRL. Although obesity alters lactation performance in humans and rodents, the responsible mechanisms have been mainly addressed in rodents." @default.
- W4307454588 created "2022-11-01" @default.
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- W4307454588 creator A5075962283 @default.
- W4307454588 date "2023-01-01" @default.
- W4307454588 modified "2023-10-18" @default.
- W4307454588 title "Obesity-derived alterations in the lactating mammary gland: Focus on prolactin" @default.
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