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- W4307460170 abstract "The role of non-coding RNAs in neuropsychiatric disorders (NPDs) is an emerging field of study. The long non-coding RNAs (lncRNAs) are shown to sponge the microRNAs (miRNAs) from interacting with their target mRNAs. Investigating the sponge activity of lncRNAs in NPDs will provide further insights into biological mechanisms and help identify disease biomarkers. In this study, a large-scale inference of the lncRNA-related miRNA sponge network of pan-neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), was carried out using brain transcriptomic (RNA-Seq) data. The candidate miRNA sponge modules were identified based on the co-expression pattern of non-coding RNAs, sharing of miRNA binding sites, and sensitivity canonical correlation. miRNA sponge modules are associated with chemical synaptic transmission, nervous system development, metabolism, immune system response, ribosomes, and pathways in cancer. The identified modules showed similar and distinct gene expression patterns depending on the neuropsychiatric condition. The preservation of miRNA sponge modules was shown in the independent brain and blood-transcriptomic datasets of NPDs. We also identified miRNA sponging lncRNAs that may be potential diagnostic biomarkers for NPDs. Our study provides a comprehensive resource on miRNA sponging in NPDs." @default.
- W4307460170 created "2022-11-01" @default.
- W4307460170 creator A5049377745 @default.
- W4307460170 creator A5052932247 @default.
- W4307460170 date "2022-10-28" @default.
- W4307460170 modified "2023-09-26" @default.
- W4307460170 title "Inferring miRNA sponge modules across major neuropsychiatric disorders" @default.
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- W4307460170 doi "https://doi.org/10.3389/fnmol.2022.1009662" @default.
- W4307460170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36385761" @default.
- W4307460170 hasPublicationYear "2022" @default.
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