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- W4307465329 abstract "Los programas de optimización del uso de antimicrobianos (PROA) han demostrado ser una herramienta eficaz y segura, que disminuye y ajusta el uso de antimicrobianos en la práctica clínica. El beneficio mostrado es doble, por un parte reduce la presión antibiótica y, por tanto, la selección de cepas multiresistentes, y por otro disminuye los potenciales efectos deletéreos en el paciente concreto e incluso mejora el pronóstico al ajustar la elección del fármaco, la posología y los posible efectos adversos e interacciones. Los bacilos gramnegativos (BGN), especialmente aquellas cepas con mecanismos de resistencia (BGN-MDR), representan el principal problema infeccioso en las unidades de cuidados intensivos y, por tanto, son el objetivo de los PROA. En la siguiente revisión actualizaremos aquellos aspectos que combinan y justifican la relación entre los PROA y los BGN-MDR. Antimicrobial stewardship programs (ASPs) have been shown to be effective and safe, contributing to reducing and adjusting antimicrobial use in clinical practice. Such programs not only reduce antibiotic selection pressure and therefore the selection of multidrug-resistant strains, but also reduce the potential deleterious effects for individual patients and even improve the prognosis by adjusting the choice of drug and dosage, and lessening the risk of adverse effects and interactions. Gram-negative bacilli (GNB), particularly multidrug-resistant strains (MDR-GNB), represent the main infectious problem in the Intensive Care Unit (ICU), and are therefore a target for ASPs. The present review provides an update on the relationship between ASPs and MDR-GNB." @default.
- W4307465329 created "2022-11-01" @default.
- W4307465329 creator A5046413437 @default.
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- W4307465329 date "2023-02-01" @default.
- W4307465329 modified "2023-09-27" @default.
- W4307465329 title "Programas de optimización de antibióticos en la unidad de cuidados intensivos en caso de infecciones por bacilos gramnegativos multiresistentes" @default.
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- W4307465329 doi "https://doi.org/10.1016/j.medin.2022.07.007" @default.
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