Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307479781> ?p ?o ?g. }
- W4307479781 abstract "Abstract In the present study, the vulnerability associated with dermokine (DMKN), as a new trigger for the Epithelial-Mesenchymal Transition (EMT)-driven melanoma, was assessed based on a genome-wide genetic screening using transgenic. The results suggested a significantly higher DMKN expression in human Malignant Melanoma (MM), which was correlated with poor overall survival among melanoma patients, especially BRAF-mutated MM samples. Additionally, an in vitro knockdown of DMKN inhibited the cell proliferation, invasion, and apoptosis of MM cancer cells by activating ERK/MAPK signaling pathways and regulating STAT3 in downstream molecules. The interrogation of in vitro melanoma dataset and characterization of advanced melanoma samples revealed that DMKN downregulated the EMT-like transcriptional program through disrupting MET/EMT cortical actin, enhanced the expression of epithelial markers, and decreased that of mesenchymal markers. Whole-exome sequencing was presented with p.E69D and p.V91A DMKN mutations as novel somatic loss-of-function mutations. Further, the purposeful proof-of-principle modeled the interaction of ERK with p.E69D and p.V91A DMKN mutations in the ERK-MAPK kinase signaling that may be naturally associated with the EMT triggering during the melanomagenesis. These results provided preclinical evidence for the role of DMKN in shaping the EMT-like melanoma phenotype and introduced DMKN as a new exceptional responder to personalized MM therapy." @default.
- W4307479781 created "2022-11-02" @default.
- W4307479781 creator A5012949859 @default.
- W4307479781 creator A5018703913 @default.
- W4307479781 creator A5036184868 @default.
- W4307479781 creator A5041005462 @default.
- W4307479781 creator A5042214181 @default.
- W4307479781 creator A5044142881 @default.
- W4307479781 creator A5054888797 @default.
- W4307479781 creator A5060514552 @default.
- W4307479781 creator A5064848746 @default.
- W4307479781 creator A5074051259 @default.
- W4307479781 date "2022-10-28" @default.
- W4307479781 modified "2023-10-06" @default.
- W4307479781 title "Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways" @default.
- W4307479781 cites W1497713526 @default.
- W4307479781 cites W1872394536 @default.
- W4307479781 cites W1966892322 @default.
- W4307479781 cites W1969576898 @default.
- W4307479781 cites W1970161309 @default.
- W4307479781 cites W1974536477 @default.
- W4307479781 cites W1975080094 @default.
- W4307479781 cites W1980740976 @default.
- W4307479781 cites W1987044395 @default.
- W4307479781 cites W1991415686 @default.
- W4307479781 cites W1992192767 @default.
- W4307479781 cites W1994127362 @default.
- W4307479781 cites W2012289001 @default.
- W4307479781 cites W2012309077 @default.
- W4307479781 cites W2021239799 @default.
- W4307479781 cites W2025351828 @default.
- W4307479781 cites W2029667189 @default.
- W4307479781 cites W2030467932 @default.
- W4307479781 cites W2057150167 @default.
- W4307479781 cites W2064977507 @default.
- W4307479781 cites W2074104861 @default.
- W4307479781 cites W2076357933 @default.
- W4307479781 cites W2087334334 @default.
- W4307479781 cites W2091286829 @default.
- W4307479781 cites W2102729801 @default.
- W4307479781 cites W2105638686 @default.
- W4307479781 cites W2112480941 @default.
- W4307479781 cites W2120772351 @default.
- W4307479781 cites W2123106337 @default.
- W4307479781 cites W2128016314 @default.
- W4307479781 cites W2128601422 @default.
- W4307479781 cites W2130410032 @default.
- W4307479781 cites W2132629607 @default.
- W4307479781 cites W2136513422 @default.
- W4307479781 cites W2150758559 @default.
- W4307479781 cites W2154019529 @default.
- W4307479781 cites W2269708716 @default.
- W4307479781 cites W2292093399 @default.
- W4307479781 cites W2319938999 @default.
- W4307479781 cites W2410865989 @default.
- W4307479781 cites W2587840780 @default.
- W4307479781 cites W2605109614 @default.
- W4307479781 cites W2727134083 @default.
- W4307479781 cites W2745178996 @default.
- W4307479781 cites W2757581310 @default.
- W4307479781 cites W2757903295 @default.
- W4307479781 cites W2767595954 @default.
- W4307479781 cites W2769792252 @default.
- W4307479781 cites W2947821829 @default.
- W4307479781 cites W2978860273 @default.
- W4307479781 cites W2982948276 @default.
- W4307479781 cites W2990615648 @default.
- W4307479781 cites W3022456551 @default.
- W4307479781 cites W3035871032 @default.
- W4307479781 cites W3036801411 @default.
- W4307479781 cites W3106075011 @default.
- W4307479781 cites W3136149174 @default.
- W4307479781 cites W3205923978 @default.
- W4307479781 cites W4214867470 @default.
- W4307479781 cites W4283220921 @default.
- W4307479781 cites W4288034030 @default.
- W4307479781 doi "https://doi.org/10.21203/rs.3.rs-2144461/v1" @default.
- W4307479781 hasPublicationYear "2022" @default.
- W4307479781 type Work @default.
- W4307479781 citedByCount "0" @default.
- W4307479781 crossrefType "posted-content" @default.
- W4307479781 hasAuthorship W4307479781A5012949859 @default.
- W4307479781 hasAuthorship W4307479781A5018703913 @default.
- W4307479781 hasAuthorship W4307479781A5036184868 @default.
- W4307479781 hasAuthorship W4307479781A5041005462 @default.
- W4307479781 hasAuthorship W4307479781A5042214181 @default.
- W4307479781 hasAuthorship W4307479781A5044142881 @default.
- W4307479781 hasAuthorship W4307479781A5054888797 @default.
- W4307479781 hasAuthorship W4307479781A5060514552 @default.
- W4307479781 hasAuthorship W4307479781A5064848746 @default.
- W4307479781 hasAuthorship W4307479781A5074051259 @default.
- W4307479781 hasBestOaLocation W43074797811 @default.
- W4307479781 hasConcept C104317684 @default.
- W4307479781 hasConcept C121608353 @default.
- W4307479781 hasConcept C127716648 @default.
- W4307479781 hasConcept C173396325 @default.
- W4307479781 hasConcept C190283241 @default.
- W4307479781 hasConcept C198826908 @default.
- W4307479781 hasConcept C2777658100 @default.
- W4307479781 hasConcept C2779013556 @default.