Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307506039> ?p ?o ?g. }
- W4307506039 endingPage "145" @default.
- W4307506039 startingPage "107" @default.
- W4307506039 abstract "Compromised autophagy and mitophagy are associated with normal aging and are correlated with the development of several age-related diseases. In this chapter, we describe the relationships among autophagy, mitophagy, aging, and age-related disease, and attempt to understand how decreases in the ability of autophagosomes and mitochondria-dedicated mitophagosomes to recycle dysfunctional cellular components lead to their accumulation and exacerbate aging. In addition, we summarize seven tentative mechanisms of mitochondrial dysfunction and discuss how the accumulation of dysfunctional mitochondria leads to energy shortages and ages cells. Finally, we highlight how an understanding of the precise interplay between fine-tuned autophagy and drivers of aging-associated pathologies will be crucial for healthy aging." @default.
- W4307506039 created "2022-11-02" @default.
- W4307506039 creator A5023105695 @default.
- W4307506039 creator A5048788845 @default.
- W4307506039 creator A5064625505 @default.
- W4307506039 date "2023-01-01" @default.
- W4307506039 modified "2023-09-27" @default.
- W4307506039 title "Autophagy and bioenergetics in aging" @default.
- W4307506039 cites W1104912482 @default.
- W4307506039 cites W1565351177 @default.
- W4307506039 cites W1751574485 @default.
- W4307506039 cites W1797578063 @default.
- W4307506039 cites W1959721425 @default.
- W4307506039 cites W1964483580 @default.
- W4307506039 cites W1965707131 @default.
- W4307506039 cites W1967809393 @default.
- W4307506039 cites W1969355579 @default.
- W4307506039 cites W1970554352 @default.
- W4307506039 cites W1973842058 @default.
- W4307506039 cites W1974015025 @default.
- W4307506039 cites W1974047233 @default.
- W4307506039 cites W1974939683 @default.
- W4307506039 cites W1976391651 @default.
- W4307506039 cites W1986952822 @default.
- W4307506039 cites W1988355439 @default.
- W4307506039 cites W1994674541 @default.
- W4307506039 cites W1997842854 @default.
- W4307506039 cites W1999232986 @default.
- W4307506039 cites W2006840724 @default.
- W4307506039 cites W2009891171 @default.
- W4307506039 cites W2011580247 @default.
- W4307506039 cites W2012043504 @default.
- W4307506039 cites W2012264972 @default.
- W4307506039 cites W2014205721 @default.
- W4307506039 cites W2014918593 @default.
- W4307506039 cites W2016244330 @default.
- W4307506039 cites W2016281184 @default.
- W4307506039 cites W2018563185 @default.
- W4307506039 cites W2020023492 @default.
- W4307506039 cites W2021490026 @default.
- W4307506039 cites W2024782183 @default.
- W4307506039 cites W2026197201 @default.
- W4307506039 cites W2028339345 @default.
- W4307506039 cites W2032022203 @default.
- W4307506039 cites W2032234589 @default.
- W4307506039 cites W2035392010 @default.
- W4307506039 cites W2038473565 @default.
- W4307506039 cites W2038481472 @default.
- W4307506039 cites W2040414192 @default.
- W4307506039 cites W2046178144 @default.
- W4307506039 cites W2047898810 @default.
- W4307506039 cites W2049016912 @default.
- W4307506039 cites W2051156021 @default.
- W4307506039 cites W2052991849 @default.
- W4307506039 cites W2053022803 @default.
- W4307506039 cites W2056485858 @default.
- W4307506039 cites W2063664792 @default.
- W4307506039 cites W2064853445 @default.
- W4307506039 cites W2066193715 @default.
- W4307506039 cites W2070658923 @default.
- W4307506039 cites W2074111563 @default.
- W4307506039 cites W2076477831 @default.
- W4307506039 cites W2080746576 @default.
- W4307506039 cites W2081453152 @default.
- W4307506039 cites W2082425146 @default.
- W4307506039 cites W2084141237 @default.
- W4307506039 cites W2084796956 @default.
- W4307506039 cites W2085525271 @default.
- W4307506039 cites W2090711760 @default.
- W4307506039 cites W2093521208 @default.
- W4307506039 cites W2094026960 @default.
- W4307506039 cites W2098028110 @default.
- W4307506039 cites W2099934453 @default.
- W4307506039 cites W2101802274 @default.
- W4307506039 cites W2106177167 @default.
- W4307506039 cites W2112299930 @default.
- W4307506039 cites W2113031692 @default.
- W4307506039 cites W2113333476 @default.
- W4307506039 cites W2118479885 @default.
- W4307506039 cites W2118742454 @default.
- W4307506039 cites W2122341467 @default.
- W4307506039 cites W2124098526 @default.
- W4307506039 cites W2126133274 @default.
- W4307506039 cites W2126525177 @default.
- W4307506039 cites W2129687643 @default.
- W4307506039 cites W2130682212 @default.
- W4307506039 cites W2131387907 @default.
- W4307506039 cites W2135581873 @default.
- W4307506039 cites W2139425230 @default.
- W4307506039 cites W2146124002 @default.
- W4307506039 cites W2147322476 @default.
- W4307506039 cites W2149356826 @default.
- W4307506039 cites W2152165298 @default.
- W4307506039 cites W2153188271 @default.
- W4307506039 cites W2153850374 @default.
- W4307506039 cites W2154164675 @default.
- W4307506039 cites W2161252138 @default.
- W4307506039 cites W2161899812 @default.