FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307510102> ?p ?o ?g. }

• W4307510102 abstract "Several chronic inflammatory diseases are associated with non-resolving inflammation. Conventional anti-inflammatory drugs fail to completely cure these diseases. Resolution pharmacology is a new therapeutic approach based on the use of pro-resolving mediators that accelerate the resolution phase of inflammation by targeting the productive phase of inflammation. Indeed, pro-resolving mediators prevent leukocyte recruitment and induce apoptosis of accumulated leukocytes. This approach is now called resolution therapy with the introduction of complex biological drugs and cell-based therapies. The main objective of resolution therapy is to specifically reduce the duration of the resolution phase to accelerate the return to homeostasis. Under physiological conditions, macrophages play a critical role in the resolution of inflammation. Indeed, after the removal of apoptotic cells (a process called efferocytosis), macrophages display anti-inflammatory reprogramming and subsequently secrete multiple pro-resolving factors. These factors can be used as resolution therapy. Here, we review the different mechanisms leading to anti-inflammatory reprogramming of macrophages after efferocytosis and the pro-resolving factors released by these efferocytic macrophages. We classify these mechanisms in three different categories: macrophage reprogramming induced by apoptotic cell-derived factors, by molecules expressed by apoptotic cells (i.e., eat-me signals), and induced by the digestion of apoptotic cell-derived materials. We also evoke that macrophage reprogramming may result from cooperative mechanisms, for instance, implicating the apoptotic cell-induced microenvironment (including cellular metabolites, specific cytokines or immune cells). Then, we describe a new drug candidate belonging to this resolution therapy. This candidate, called SuperMApo, corresponds to the secretome of efferocytic macrophages. We discuss its production, the pro-resolving factors present in this drug, as well as the results obtained in experimental models of chronic (e.g., arthritis, colitis) and acute (e.g., peritonitis or xenogeneic graft-versus-host disease) inflammatory diseases." @default.
• W4307510102 created "2022-11-02" @default.
• W4307510102 creator A5002153731 @default.
• W4307510102 creator A5005318792 @default.
• W4307510102 creator A5024113102 @default.
• W4307510102 creator A5065004424 @default.
• W4307510102 creator A5084149711 @default.
• W4307510102 date "2022-10-28" @default.
• W4307510102 modified "2023-10-14" @default.
• W4307510102 title "Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation" @default.
• W4307510102 cites W1486344723 @default.
• W4307510102 cites W1506446583 @default.
• W4307510102 cites W1573103899 @default.
• W4307510102 cites W1610241671 @default.
• W4307510102 cites W1667820694 @default.
• W4307510102 cites W1776411292 @default.
• W4307510102 cites W1832818975 @default.
• W4307510102 cites W1856034726 @default.
• W4307510102 cites W1872008999 @default.
• W4307510102 cites W1940692702 @default.
• W4307510102 cites W1965169996 @default.
• W4307510102 cites W1968442371 @default.
• W4307510102 cites W1982954455 @default.
• W4307510102 cites W1985891126 @default.
• W4307510102 cites W1995299599 @default.
• W4307510102 cites W1997349847 @default.
• W4307510102 cites W2004536682 @default.
• W4307510102 cites W2011573742 @default.
• W4307510102 cites W2012060788 @default.
• W4307510102 cites W2018846024 @default.
• W4307510102 cites W2022561792 @default.
• W4307510102 cites W2027344845 @default.
• W4307510102 cites W2028906750 @default.
• W4307510102 cites W2031259207 @default.
• W4307510102 cites W2032624312 @default.
• W4307510102 cites W2032730667 @default.
• W4307510102 cites W2036714958 @default.
• W4307510102 cites W2037231636 @default.
• W4307510102 cites W2037416158 @default.
• W4307510102 cites W2060334482 @default.
• W4307510102 cites W2060659287 @default.
• W4307510102 cites W2061123122 @default.
• W4307510102 cites W2063099598 @default.
• W4307510102 cites W2063632665 @default.
• W4307510102 cites W2067161489 @default.
• W4307510102 cites W2076003134 @default.
• W4307510102 cites W2081832076 @default.
• W4307510102 cites W2088058388 @default.
• W4307510102 cites W2090609282 @default.
• W4307510102 cites W2094659815 @default.
• W4307510102 cites W2095474336 @default.
• W4307510102 cites W2095537212 @default.
• W4307510102 cites W2112422450 @default.
• W4307510102 cites W2113804525 @default.
• W4307510102 cites W2116505573 @default.
• W4307510102 cites W2122632396 @default.
• W4307510102 cites W2126106255 @default.
• W4307510102 cites W2126864422 @default.
• W4307510102 cites W2127910234 @default.
• W4307510102 cites W2128864178 @default.
• W4307510102 cites W2129205142 @default.
• W4307510102 cites W2133496985 @default.
• W4307510102 cites W2134961193 @default.
• W4307510102 cites W2138671479 @default.
• W4307510102 cites W2141827506 @default.
• W4307510102 cites W2144741217 @default.
• W4307510102 cites W2146276289 @default.
• W4307510102 cites W2146921697 @default.
• W4307510102 cites W2151181789 @default.
• W4307510102 cites W2153454088 @default.
• W4307510102 cites W2158006372 @default.
• W4307510102 cites W2159560463 @default.
• W4307510102 cites W2159913536 @default.
• W4307510102 cites W2162166699 @default.
• W4307510102 cites W2162645937 @default.
• W4307510102 cites W2163175900 @default.
• W4307510102 cites W2163260252 @default.
• W4307510102 cites W2169434098 @default.
• W4307510102 cites W2176134716 @default.
• W4307510102 cites W2324299990 @default.
• W4307510102 cites W2326448510 @default.
• W4307510102 cites W2333427125 @default.
• W4307510102 cites W2415209394 @default.
• W4307510102 cites W2473681996 @default.
• W4307510102 cites W2504045125 @default.
• W4307510102 cites W2510831706 @default.
• W4307510102 cites W2516344353 @default.
• W4307510102 cites W2548414910 @default.
• W4307510102 cites W2568405604 @default.
• W4307510102 cites W2605907314 @default.
• W4307510102 cites W2612072527 @default.
• W4307510102 cites W2622909676 @default.
• W4307510102 cites W2672444148 @default.
• W4307510102 cites W2755895700 @default.
• W4307510102 cites W2759089822 @default.
• W4307510102 cites W2762696833 @default.
• W4307510102 cites W2766435905 @default.
• W4307510102 cites W2769990542 @default.
• W4307510102 cites W2792070982 @default.
• W4307510102 cites W2792980100 @default.

• next