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• W4307515308 abstract "ABSTRACT Relatedness coefficients which measure the genetic similarity of groups of genes (either three or four) are described. Cumulants and not moments are needed for four-gene probabilities, and also, the normalized fourth cumulant is the probability of identical-by-descent of all four genes. With four genes, a covariance of homozygosity between pairs of genes arises when populations follow a mixture distribution. Applications of three gene coefficients mainly involve conditional regression, and applications of four gene coefficients can involve identity disequilibrium. A novel estimator for identity disequilibrium emerges from calculations involving the cumulant. -Estimation of three- and four-gene relatedness using genetic marker data is briefly discussed. Three- and four-gene estimators explore new territory but suffer from statistical and numerical problems, including higher statistical variance, complexity of estimation formula, and non-estimability at some intermediate allele frequencies." @default.
• W4307515308 created "2022-11-02" @default.
• W4307515308 creator A5085029146 @default.
• W4307515308 date "2022-10-28" @default.
• W4307515308 modified "2023-10-16" @default.
• W4307515308 title "Relatedness coefficients and their applications for triplets and quartets of genes" @default.
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• W4307515308 doi "https://doi.org/10.1101/2022.10.28.514212" @default.
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