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- W4307515422 abstract "Lactic acid production has been regarded as a mechanism by which malignant cells escape immunosurveillance. Recent technological advances in mass spectrometry and the use of cell culture media with a physiological nutrient composition have shed new light on the role of lactic acid and its conjugate lactate in the tumor microenvironment. Here, we review novel work identifying lactate as a physiological carbon source for mammalian tumors and immune cells. We highlight evidence that its use as a substrate is distinct from the immunosuppressive acidification of the extracellular milieu by lactic acid protons. Together, data suggest that neutralizing the effects of intratumoral acidity while maintaining physiological lactate metabolism in cytotoxic CD8+ T cells should be pursued to boost anti-tumor immunity." @default.
- W4307515422 created "2022-11-02" @default.
- W4307515422 creator A5039577684 @default.
- W4307515422 creator A5061159858 @default.
- W4307515422 date "2022-12-01" @default.
- W4307515422 modified "2023-10-14" @default.
- W4307515422 title "Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment" @default.
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- W4307515422 doi "https://doi.org/10.1016/j.it.2022.10.005" @default.
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