Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307533710> ?p ?o ?g. }
- W4307533710 endingPage "35" @default.
- W4307533710 startingPage "5" @default.
- W4307533710 abstract "It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on central nervous system (CNS) function. In the 40 years since cannabinoids were found to trigger specific cell signaling cascades, studies of the ECS system continue to cause amazement, surprise, and confusion! CB1 cannabinoid receptors are expressed widely in the CNS and regulate cell–cell communication via effects on the release of both neurotransmitters and gliotransmitters. CB2 cannabinoid receptors are difficult to detect in the CNS but seem to “punch above their weight” as compounds targeting these receptors have significant effects on inflammatory state and behavior. Positive and negative allosteric modulators for both receptors have been identified and examined in preclinical studies. Concentrations of the endocannabinoid ligands, N-arachidonoylethanolamine and 2-arachidonoylglycerol (2-AG), are regulated by a combination of enzymatic synthesis and degradation and inhibitors of these processes are available and making their way into clinical trials. Importantly, ECS regulates many essential brain functions, including regulation of reward, anxiety, inflammation, motor control, and cellular development. While the field is on the cusp of preclinical discoveries providing impactful clinical and therapeutic insights into many CNS disorders, there is still much to be learned about this remarkable and versatile modulatory system." @default.
- W4307533710 created "2022-11-03" @default.
- W4307533710 creator A5058978596 @default.
- W4307533710 creator A5061605827 @default.
- W4307533710 creator A5072247618 @default.
- W4307533710 creator A5076410915 @default.
- W4307533710 creator A5089849206 @default.
- W4307533710 creator A5029582399 @default.
- W4307533710 date "2022-10-29" @default.
- W4307533710 modified "2023-10-15" @default.
- W4307533710 title "Endocannabinoid signaling in the central nervous system" @default.
- W4307533710 cites W1480176511 @default.
- W4307533710 cites W1488329806 @default.
- W4307533710 cites W1494787392 @default.
- W4307533710 cites W1534915247 @default.
- W4307533710 cites W1537201002 @default.
- W4307533710 cites W1537637522 @default.
- W4307533710 cites W1542528083 @default.
- W4307533710 cites W1552423677 @default.
- W4307533710 cites W1583336701 @default.
- W4307533710 cites W1587193299 @default.
- W4307533710 cites W1596640114 @default.
- W4307533710 cites W1627321564 @default.
- W4307533710 cites W1645330008 @default.
- W4307533710 cites W1654380405 @default.
- W4307533710 cites W1774176118 @default.
- W4307533710 cites W1781506262 @default.
- W4307533710 cites W1803077191 @default.
- W4307533710 cites W1832918544 @default.
- W4307533710 cites W1844090762 @default.
- W4307533710 cites W1851155939 @default.
- W4307533710 cites W1880519341 @default.
- W4307533710 cites W1892183859 @default.
- W4307533710 cites W192803623 @default.
- W4307533710 cites W1945751328 @default.
- W4307533710 cites W1960914895 @default.
- W4307533710 cites W1961369080 @default.
- W4307533710 cites W1963736429 @default.
- W4307533710 cites W1964019154 @default.
- W4307533710 cites W1964395752 @default.
- W4307533710 cites W1968083340 @default.
- W4307533710 cites W1969821478 @default.
- W4307533710 cites W1970307887 @default.
- W4307533710 cites W1971125401 @default.
- W4307533710 cites W1974642601 @default.
- W4307533710 cites W1976127510 @default.
- W4307533710 cites W1978147839 @default.
- W4307533710 cites W1979938143 @default.
- W4307533710 cites W1980021996 @default.
- W4307533710 cites W1980153635 @default.
- W4307533710 cites W1980826175 @default.
- W4307533710 cites W1982429227 @default.
- W4307533710 cites W1984821738 @default.
- W4307533710 cites W1989073099 @default.
- W4307533710 cites W1989353122 @default.
- W4307533710 cites W1989756472 @default.
- W4307533710 cites W1990916210 @default.
- W4307533710 cites W1991631628 @default.
- W4307533710 cites W1991905988 @default.
- W4307533710 cites W1994470497 @default.
- W4307533710 cites W1998012110 @default.
- W4307533710 cites W1999113156 @default.
- W4307533710 cites W2000076301 @default.
- W4307533710 cites W2001276618 @default.
- W4307533710 cites W2001858901 @default.
- W4307533710 cites W2002309357 @default.
- W4307533710 cites W2002935274 @default.
- W4307533710 cites W2003159048 @default.
- W4307533710 cites W2006320873 @default.
- W4307533710 cites W2006743927 @default.
- W4307533710 cites W2006860928 @default.
- W4307533710 cites W2006954988 @default.
- W4307533710 cites W2007402666 @default.
- W4307533710 cites W2009980006 @default.
- W4307533710 cites W2011161535 @default.
- W4307533710 cites W2012507391 @default.
- W4307533710 cites W2015639824 @default.
- W4307533710 cites W2016078643 @default.
- W4307533710 cites W2018780060 @default.
- W4307533710 cites W2018953051 @default.
- W4307533710 cites W2020520223 @default.
- W4307533710 cites W2021332276 @default.
- W4307533710 cites W2023086309 @default.
- W4307533710 cites W2024653583 @default.
- W4307533710 cites W2026795663 @default.
- W4307533710 cites W2027642569 @default.
- W4307533710 cites W2027736570 @default.
- W4307533710 cites W2028603831 @default.
- W4307533710 cites W2029181309 @default.
- W4307533710 cites W2029471635 @default.
- W4307533710 cites W2032116213 @default.
- W4307533710 cites W2033211327 @default.
- W4307533710 cites W2039598436 @default.
- W4307533710 cites W2040032122 @default.
- W4307533710 cites W2040268671 @default.
- W4307533710 cites W2041374344 @default.
- W4307533710 cites W2041890590 @default.
- W4307533710 cites W2044219916 @default.