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- W4307550883 endingPage "12864" @default.
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- W4307550883 abstract "Gestational diabetes mellitus (GDM) is recognized as a “window of opportunity” for the future prediction of such complications as type 2 diabetes mellitus and pelvic floor muscle disorders, including urinary incontinence and genitourinary dysfunction. Translational studies have reported that pelvic floor muscle disorders are due to a GDM-induced-myopathy (GDiM) of the pelvic floor muscle and rectus abdominis muscle (RAM). We now describe the transcriptome profiling of the RAM obtained by Cesarean section from GDM and non-GDM women with and without pregnancy-specific urinary incontinence (PSUI). We identified 650 genes in total, and the differentially expressed genes were defined by comparing three control groups to the GDM with PSUI group (GDiM). Enrichment analysis showed that GDM with PSUI was associated with decreased gene expression related to muscle structure and muscle protein synthesis, the reduced ability of muscle fibers to ameliorate muscle damage, and the altered the maintenance and generation of energy through glycogenesis. Potential genetic muscle biomarkers were validated by RT-PCR, and their relationship to the pathophysiology of the disease was verified. These findings help elucidate the molecular mechanisms of GDiM and will promote the development of innovative interventions to prevent and treat complications such as post-GDM urinary incontinence." @default.
- W4307550883 created "2022-11-03" @default.
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- W4307550883 date "2022-10-25" @default.
- W4307550883 modified "2023-10-15" @default.
- W4307550883 title "Transcriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence" @default.
- W4307550883 cites W1490161904 @default.
- W4307550883 cites W1560020441 @default.
- W4307550883 cites W1565787657 @default.
- W4307550883 cites W1565998984 @default.
- W4307550883 cites W1589362323 @default.
- W4307550883 cites W1668185783 @default.
- W4307550883 cites W1816176398 @default.
- W4307550883 cites W1903090781 @default.
- W4307550883 cites W1963976420 @default.
- W4307550883 cites W1967285554 @default.
- W4307550883 cites W1967312126 @default.
- W4307550883 cites W1987355536 @default.
- W4307550883 cites W1998358364 @default.
- W4307550883 cites W2012139407 @default.
- W4307550883 cites W2014901805 @default.
- W4307550883 cites W2016556811 @default.
- W4307550883 cites W2026357888 @default.
- W4307550883 cites W2032019813 @default.
- W4307550883 cites W2039500915 @default.
- W4307550883 cites W2049797247 @default.
- W4307550883 cites W2053337893 @default.
- W4307550883 cites W2058061580 @default.
- W4307550883 cites W2065806200 @default.
- W4307550883 cites W2074780154 @default.
- W4307550883 cites W2099224474 @default.
- W4307550883 cites W2101351031 @default.
- W4307550883 cites W2101489273 @default.
- W4307550883 cites W2102278945 @default.
- W4307550883 cites W2108244474 @default.
- W4307550883 cites W2108664016 @default.
- W4307550883 cites W2108828732 @default.
- W4307550883 cites W2110075716 @default.
- W4307550883 cites W2111648449 @default.
- W4307550883 cites W2111681103 @default.
- W4307550883 cites W2114819974 @default.
- W4307550883 cites W2125776650 @default.
- W4307550883 cites W2130025116 @default.
- W4307550883 cites W2131271579 @default.
- W4307550883 cites W2134526812 @default.
- W4307550883 cites W2137937538 @default.
- W4307550883 cites W2145506897 @default.
- W4307550883 cites W2150157189 @default.
- W4307550883 cites W2156664292 @default.
- W4307550883 cites W2160203942 @default.
- W4307550883 cites W2160211399 @default.
- W4307550883 cites W2165869751 @default.
- W4307550883 cites W2166129278 @default.
- W4307550883 cites W2168498537 @default.
- W4307550883 cites W2170651583 @default.
- W4307550883 cites W2171553260 @default.
- W4307550883 cites W2179438025 @default.
- W4307550883 cites W2286828127 @default.
- W4307550883 cites W2296754069 @default.
- W4307550883 cites W2343346571 @default.
- W4307550883 cites W2537623931 @default.
- W4307550883 cites W2593371426 @default.
- W4307550883 cites W2619936702 @default.
- W4307550883 cites W2773467888 @default.
- W4307550883 cites W2785203166 @default.
- W4307550883 cites W2793197607 @default.
- W4307550883 cites W2804344435 @default.
- W4307550883 cites W2806500078 @default.
- W4307550883 cites W2978045147 @default.
- W4307550883 cites W2979921170 @default.
- W4307550883 cites W2983470523 @default.
- W4307550883 cites W2996841993 @default.
- W4307550883 cites W3009116440 @default.
- W4307550883 cites W3011908484 @default.
- W4307550883 cites W3012319711 @default.
- W4307550883 cites W3014610312 @default.
- W4307550883 cites W3014773013 @default.
- W4307550883 cites W3037443759 @default.
- W4307550883 cites W3042252978 @default.
- W4307550883 cites W3082783064 @default.
- W4307550883 cites W3092771217 @default.
- W4307550883 cites W3106621406 @default.
- W4307550883 cites W3139945041 @default.
- W4307550883 cites W3174960091 @default.
- W4307550883 cites W3200838742 @default.