Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307553925> ?p ?o ?g. }
- W4307553925 abstract "Multiple myeloma (MM), an incurable hematological malignancy with clonal proliferation of plasma cells, is mainly characterized by excessive production of monoclonal immunoglobulins and free light chains (FLCs). Kidney injury is one of the main clinical manifestations and is also a significant predictor of the prognosis of symptomatic MM patients, especially those who require dialysis-supported treatment. Overproduction of FLCs is the trigger for kidney injury, as they can induce the transcription of inflammatory and profibrotic cytokines in the proximal tubule and bind to Tamm-Horsfall protein in the distal tubules to form casts that obstruct the tubules, leading to kidney injury and even renal fibrosis. In addition to traditional antimyeloma treatment, high-cutoff hemodialysis (HCO-HD), which can effectively remove FLCs in vitro, has attracted much attention in recent years. Due to its greater membrane pore size, it has significant advantages in removing larger molecules and can be applied in rhabdomyolysis, sepsis, and even myeloma cast nephropathy. However, mounting questions have recently been raised regarding whether HCO-HD can truly provide clinical benefits in MM patients with acute kidney injury (AKI). Therefore, in this study, we discussed the pathological causes of AKI secondary to MM and summarized the current situation of HCO-HD in MM patients compared with other available extracorporeal techniques. In addition, pivotal clinical trials that reflect the ability of the clearance of FLCs and the side effects of HCO-HD are highlighted, and the relevant protocol of HCO-HD is also provided to assist clinicians in decision-making." @default.
- W4307553925 created "2022-11-03" @default.
- W4307553925 creator A5018338452 @default.
- W4307553925 creator A5018860616 @default.
- W4307553925 creator A5022163235 @default.
- W4307553925 creator A5043256138 @default.
- W4307553925 creator A5049037701 @default.
- W4307553925 creator A5052821016 @default.
- W4307553925 creator A5088609114 @default.
- W4307553925 creator A5089029669 @default.
- W4307553925 date "2022-10-26" @default.
- W4307553925 modified "2023-09-29" @default.
- W4307553925 title "High-cutoff hemodialysis in multiple myeloma patients with acute kidney injury" @default.
- W4307553925 cites W1586971039 @default.
- W4307553925 cites W1596107265 @default.
- W4307553925 cites W1714859988 @default.
- W4307553925 cites W1854511443 @default.
- W4307553925 cites W1966809384 @default.
- W4307553925 cites W1985497595 @default.
- W4307553925 cites W1986283895 @default.
- W4307553925 cites W1989803279 @default.
- W4307553925 cites W1993586526 @default.
- W4307553925 cites W1999692512 @default.
- W4307553925 cites W2001133874 @default.
- W4307553925 cites W2005548627 @default.
- W4307553925 cites W2009858783 @default.
- W4307553925 cites W2011585052 @default.
- W4307553925 cites W2015401558 @default.
- W4307553925 cites W2018049995 @default.
- W4307553925 cites W2018621663 @default.
- W4307553925 cites W2023503416 @default.
- W4307553925 cites W2029204292 @default.
- W4307553925 cites W2035446919 @default.
- W4307553925 cites W2039718569 @default.
- W4307553925 cites W2040296842 @default.
- W4307553925 cites W2041141081 @default.
- W4307553925 cites W2041547777 @default.
- W4307553925 cites W2047364391 @default.
- W4307553925 cites W2052227560 @default.
- W4307553925 cites W2065088660 @default.
- W4307553925 cites W2068805302 @default.
- W4307553925 cites W2081128344 @default.
- W4307553925 cites W2093621591 @default.
- W4307553925 cites W2093932653 @default.
- W4307553925 cites W2099320310 @default.
- W4307553925 cites W2125749190 @default.
- W4307553925 cites W2137282054 @default.
- W4307553925 cites W2141013094 @default.
- W4307553925 cites W2141723966 @default.
- W4307553925 cites W2141890910 @default.
- W4307553925 cites W2144728882 @default.
- W4307553925 cites W2146429012 @default.
- W4307553925 cites W2149024804 @default.
- W4307553925 cites W2158520275 @default.
- W4307553925 cites W2160088903 @default.
- W4307553925 cites W2161061011 @default.
- W4307553925 cites W2246072370 @default.
- W4307553925 cites W2277498048 @default.
- W4307553925 cites W2347160971 @default.
- W4307553925 cites W2414861008 @default.
- W4307553925 cites W2462482648 @default.
- W4307553925 cites W2464086297 @default.
- W4307553925 cites W2484473885 @default.
- W4307553925 cites W2508561205 @default.
- W4307553925 cites W2512106959 @default.
- W4307553925 cites W2534189832 @default.
- W4307553925 cites W2740943564 @default.
- W4307553925 cites W2763225603 @default.
- W4307553925 cites W2774525828 @default.
- W4307553925 cites W2792167763 @default.
- W4307553925 cites W2795775889 @default.
- W4307553925 cites W2803679599 @default.
- W4307553925 cites W2804729294 @default.
- W4307553925 cites W2886687335 @default.
- W4307553925 cites W2900464803 @default.
- W4307553925 cites W2920943859 @default.
- W4307553925 cites W2948728876 @default.
- W4307553925 cites W2951150370 @default.
- W4307553925 cites W2954456641 @default.
- W4307553925 cites W3002639088 @default.
- W4307553925 cites W3003722795 @default.
- W4307553925 cites W3010143203 @default.
- W4307553925 cites W3012328912 @default.
- W4307553925 cites W3016908366 @default.
- W4307553925 cites W3034694727 @default.
- W4307553925 cites W3048901826 @default.
- W4307553925 cites W3115708157 @default.
- W4307553925 cites W3119550966 @default.
- W4307553925 cites W3147894636 @default.
- W4307553925 cites W3187363447 @default.
- W4307553925 cites W4210734847 @default.
- W4307553925 cites W4211058750 @default.
- W4307553925 cites W4211125162 @default.
- W4307553925 cites W4252175385 @default.
- W4307553925 doi "https://doi.org/10.3389/fonc.2022.1024133" @default.
- W4307553925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36387107" @default.
- W4307553925 hasPublicationYear "2022" @default.
- W4307553925 type Work @default.
- W4307553925 citedByCount "1" @default.
- W4307553925 countsByYear W43075539252023 @default.