Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307568105> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4307568105 endingPage "65" @default.
- W4307568105 startingPage "57" @default.
- W4307568105 abstract "Lenalidomide is an immunomodulatory drug and is very effective in the management of a number of malignancies, including multiple myeloma. Like thalidomide, lenalidomide interacts with the cereblon E3 ligase complex, which results in targeted destruction of proteins. This study was conducted to study the teratogenic potential of lenalidomide when administered to pregnant cynomolgus monkeys. Lenalidomide was administered orally on gestation days 20-50 at dosages of 0 (vehicle control), 0.5, 1, 2 and 4 mg/kg/day. Thalidomide was used as a positive control and was administered orally at 15 mg/kg/day on gestation days 26-28. Each group consisted of 5 pregnant monkeys. Pregnancy was terminated on gestation day 100 ± 1 by cesarean section and fetuses examined for external, internal and skeletal changes. Intrauterine loss was 40% in the thalidomide group and 20 % in each of the lenalidomide 2 and 4 mg/kg/day groups. Treatment with lenalidomide and thalidomide resulted in no effects on placental weights, fetal body weights and body measurements. External fetal examination revealed malformations in fetuses of all lenalidomide-treated groups, including malformations of upper and lower extremities. These external malformations had correlated skeletal findings and were similar to those seen in the thalidomide-treated group, where two of three fetuses showed the classic thalidomide syndrome of malformed upper and lower extremities. A no-observed-adverse-effect level was not identified in this study, and the mean maternal exposures at the lowest dosage, where fetal malformations were observed, were 5-folder lower than the exposures observed in the MM patients treated with 25 mg of lenalidomide." @default.
- W4307568105 created "2022-11-03" @default.
- W4307568105 creator A5017425415 @default.
- W4307568105 creator A5027132403 @default.
- W4307568105 creator A5038853688 @default.
- W4307568105 date "2022-12-01" @default.
- W4307568105 modified "2023-10-18" @default.
- W4307568105 title "Embryo-fetal exposure and developmental outcome of lenalidomide following oral administration to pregnant cynomolgus monkeys" @default.
- W4307568105 cites W1973999018 @default.
- W4307568105 cites W1977228369 @default.
- W4307568105 cites W1997952190 @default.
- W4307568105 cites W2005505584 @default.
- W4307568105 cites W2012276529 @default.
- W4307568105 cites W2015345028 @default.
- W4307568105 cites W2049525919 @default.
- W4307568105 cites W2068412287 @default.
- W4307568105 cites W2068548260 @default.
- W4307568105 cites W2076901039 @default.
- W4307568105 cites W2081823345 @default.
- W4307568105 cites W2084778320 @default.
- W4307568105 cites W2089781472 @default.
- W4307568105 cites W2094066803 @default.
- W4307568105 cites W2156380604 @default.
- W4307568105 cites W2161413435 @default.
- W4307568105 cites W2409675974 @default.
- W4307568105 cites W2462945035 @default.
- W4307568105 cites W2886283685 @default.
- W4307568105 cites W2891710607 @default.
- W4307568105 doi "https://doi.org/10.1016/j.reprotox.2022.10.005" @default.
- W4307568105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36309155" @default.
- W4307568105 hasPublicationYear "2022" @default.
- W4307568105 type Work @default.
- W4307568105 citedByCount "1" @default.
- W4307568105 countsByYear W43075681052023 @default.
- W4307568105 crossrefType "journal-article" @default.
- W4307568105 hasAuthorship W4307568105A5017425415 @default.
- W4307568105 hasAuthorship W4307568105A5027132403 @default.
- W4307568105 hasAuthorship W4307568105A5038853688 @default.
- W4307568105 hasConcept C126322002 @default.
- W4307568105 hasConcept C172680121 @default.
- W4307568105 hasConcept C2776063141 @default.
- W4307568105 hasConcept C2776364478 @default.
- W4307568105 hasConcept C2779234561 @default.
- W4307568105 hasConcept C2779609412 @default.
- W4307568105 hasConcept C46973012 @default.
- W4307568105 hasConcept C54355233 @default.
- W4307568105 hasConcept C65290608 @default.
- W4307568105 hasConcept C71924100 @default.
- W4307568105 hasConcept C86803240 @default.
- W4307568105 hasConceptScore W4307568105C126322002 @default.
- W4307568105 hasConceptScore W4307568105C172680121 @default.
- W4307568105 hasConceptScore W4307568105C2776063141 @default.
- W4307568105 hasConceptScore W4307568105C2776364478 @default.
- W4307568105 hasConceptScore W4307568105C2779234561 @default.
- W4307568105 hasConceptScore W4307568105C2779609412 @default.
- W4307568105 hasConceptScore W4307568105C46973012 @default.
- W4307568105 hasConceptScore W4307568105C54355233 @default.
- W4307568105 hasConceptScore W4307568105C65290608 @default.
- W4307568105 hasConceptScore W4307568105C71924100 @default.
- W4307568105 hasConceptScore W4307568105C86803240 @default.
- W4307568105 hasFunder F4320309086 @default.
- W4307568105 hasLocation W43075681051 @default.
- W4307568105 hasLocation W43075681052 @default.
- W4307568105 hasOpenAccess W4307568105 @default.
- W4307568105 hasPrimaryLocation W43075681051 @default.
- W4307568105 hasRelatedWork W16535586 @default.
- W4307568105 hasRelatedWork W1974135782 @default.
- W4307568105 hasRelatedWork W2025555311 @default.
- W4307568105 hasRelatedWork W2041042375 @default.
- W4307568105 hasRelatedWork W2118112957 @default.
- W4307568105 hasRelatedWork W2125645064 @default.
- W4307568105 hasRelatedWork W2161704880 @default.
- W4307568105 hasRelatedWork W2192430028 @default.
- W4307568105 hasRelatedWork W2796590081 @default.
- W4307568105 hasRelatedWork W1941943869 @default.
- W4307568105 hasVolume "114" @default.
- W4307568105 isParatext "false" @default.
- W4307568105 isRetracted "false" @default.
- W4307568105 workType "article" @default.