FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307582021> ?p ?o ?g. }

• W4307582021 endingPage "430" @default.
• W4307582021 startingPage "415" @default.
• W4307582021 abstract "Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain; however, their function is rather heterogeneous in respect to their origin, location, receptor/channel expression and age. The basic helix-loop-helix transcription factor Olig2 is expressed in all OPCs as a pivotal determinant of their differentiation. Here, we identified a subset (2%-26%) of OPCs lacking Olig2 in various brain regions including cortex, corpus callosum, CA1 and dentate gyrus. These Olig2 negative (Olig2neg ) OPCs were enriched in the juvenile brain and decreased subsequently with age, being rarely detectable in the adult brain. However, the loss of this population was not due to apoptosis or microglia-dependent phagocytosis. Unlike Olig2pos OPCs, these subset cells were rarely labeled for the mitotic marker Ki67. And, accordingly, BrdU was incorporated only by a three-day long-term labeling but not by a 2-hour short pulse, suggesting these cells do not proliferate any more but were derived from proliferating OPCs. The Olig2neg OPCs exhibited a less complex morphology than Olig2pos ones. Olig2neg OPCs preferentially remain in a precursor stage rather than differentiating into highly branched oligodendrocytes. Changing the adjacent brain environment, for example, by acute injuries or by complex motor learning tasks, stimulated the transition of Olig2pos OPCs to Olig2neg cells in the adult. Taken together, our results demonstrate that OPCs transiently suppress Olig2 upon changes of the brain activity." @default.
• W4307582021 created "2022-11-03" @default.
• W4307582021 creator A5006134721 @default.
• W4307582021 creator A5008417603 @default.
• W4307582021 creator A5009493618 @default.
• W4307582021 creator A5021133690 @default.
• W4307582021 creator A5026074268 @default.
• W4307582021 creator A5065217953 @default.
• W4307582021 creator A5069678891 @default.
• W4307582021 creator A5074956035 @default.
• W4307582021 date "2022-10-29" @default.
• W4307582021 modified "2023-10-17" @default.
• W4307582021 title "A subset of <scp>OPCs</scp> do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning" @default.
• W4307582021 cites W1446040360 @default.
• W4307582021 cites W1519559613 @default.
• W4307582021 cites W1787881236 @default.
• W4307582021 cites W2001888569 @default.
• W4307582021 cites W2012666288 @default.
• W4307582021 cites W2013717885 @default.
• W4307582021 cites W2016494612 @default.
• W4307582021 cites W2017818222 @default.
• W4307582021 cites W2018221515 @default.
• W4307582021 cites W2022284098 @default.
• W4307582021 cites W2023105628 @default.
• W4307582021 cites W2023132306 @default.
• W4307582021 cites W2029606645 @default.
• W4307582021 cites W2040207158 @default.
• W4307582021 cites W2040787182 @default.
• W4307582021 cites W2041848372 @default.
• W4307582021 cites W2045013955 @default.
• W4307582021 cites W2045926445 @default.
• W4307582021 cites W2049212652 @default.
• W4307582021 cites W2062159906 @default.
• W4307582021 cites W2066688251 @default.
• W4307582021 cites W2079574859 @default.
• W4307582021 cites W2082178034 @default.
• W4307582021 cites W2085525762 @default.
• W4307582021 cites W2095490681 @default.
• W4307582021 cites W2104135721 @default.
• W4307582021 cites W2117719082 @default.
• W4307582021 cites W2124019758 @default.
• W4307582021 cites W2125920059 @default.
• W4307582021 cites W2128464557 @default.
• W4307582021 cites W2129605816 @default.
• W4307582021 cites W2133437679 @default.
• W4307582021 cites W2133465414 @default.
• W4307582021 cites W2147191089 @default.
• W4307582021 cites W2148787277 @default.
• W4307582021 cites W2158217645 @default.
• W4307582021 cites W2164236178 @default.
• W4307582021 cites W2345641371 @default.
• W4307582021 cites W2415341492 @default.
• W4307582021 cites W2520705953 @default.
• W4307582021 cites W2734685071 @default.
• W4307582021 cites W2784817310 @default.
• W4307582021 cites W2797019545 @default.
• W4307582021 cites W2800392236 @default.
• W4307582021 cites W2887204823 @default.
• W4307582021 cites W2909833689 @default.
• W4307582021 cites W2923609876 @default.
• W4307582021 cites W2941593046 @default.
• W4307582021 cites W2962802006 @default.
• W4307582021 cites W2968420254 @default.
• W4307582021 cites W2974011413 @default.
• W4307582021 cites W3006081887 @default.
• W4307582021 cites W3080685366 @default.
• W4307582021 cites W3084165391 @default.
• W4307582021 cites W3093786898 @default.
• W4307582021 cites W3128662823 @default.
• W4307582021 cites W3174463899 @default.
• W4307582021 cites W3203733253 @default.
• W4307582021 cites W4220695862 @default.
• W4307582021 cites W4220888877 @default.
• W4307582021 cites W4221003986 @default.
• W4307582021 cites W4295037725 @default.
• W4307582021 doi "https://doi.org/10.1002/glia.24284" @default.
• W4307582021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36308278" @default.
• W4307582021 hasPublicationYear "2022" @default.
• W4307582021 type Work @default.
• W4307582021 citedByCount "5" @default.
• W4307582021 countsByYear W43075820212023 @default.
• W4307582021 crossrefType "journal-article" @default.
• W4307582021 hasAuthorship W4307582021A5006134721 @default.
• W4307582021 hasAuthorship W4307582021A5008417603 @default.
• W4307582021 hasAuthorship W4307582021A5009493618 @default.
• W4307582021 hasAuthorship W4307582021A5021133690 @default.
• W4307582021 hasAuthorship W4307582021A5026074268 @default.
• W4307582021 hasAuthorship W4307582021A5065217953 @default.
• W4307582021 hasAuthorship W4307582021A5069678891 @default.
• W4307582021 hasAuthorship W4307582021A5074956035 @default.
• W4307582021 hasBestOaLocation W43075820211 @default.
• W4307582021 hasConcept C136834591 @default.
• W4307582021 hasConcept C169760540 @default.
• W4307582021 hasConcept C203014093 @default.
• W4307582021 hasConcept C2776464000 @default.
• W4307582021 hasConcept C2776914184 @default.
• W4307582021 hasConcept C2776985911 @default.
• W4307582021 hasConcept C2777348757 @default.

• next