Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307588226> ?p ?o ?g. }
- W4307588226 abstract "Abstract Spatial omics technologies can help identify spatially organized biological processes, but existing computational approaches often overlook structural dependencies in the data. Here, we introduce Smoother, a unified framework that integrates positional information into non-spatial models via modular priors and losses. In simulated and real datasets, Smoother enables accurate data imputation, cell-type deconvolution, and dimensionality reduction with remarkable efficiency. In colorectal cancer, Smoother-guided deconvolution revealed plasma cell and fibroblast subtype localizations linked to tumor microenvironment restructuring. Additionally, joint modeling of spatial and single-cell human prostate data with Smoother allowed for spatial mapping of reference populations with significantly reduced ambiguity." @default.
- W4307588226 created "2022-11-03" @default.
- W4307588226 creator A5000245536 @default.
- W4307588226 creator A5012226169 @default.
- W4307588226 creator A5013311924 @default.
- W4307588226 creator A5038705974 @default.
- W4307588226 creator A5052100404 @default.
- W4307588226 creator A5056128255 @default.
- W4307588226 creator A5067368955 @default.
- W4307588226 creator A5073479976 @default.
- W4307588226 creator A5081351428 @default.
- W4307588226 creator A5085310630 @default.
- W4307588226 date "2022-10-27" @default.
- W4307588226 modified "2023-10-16" @default.
- W4307588226 title "A Unified Modular Framework to Incorporate Structural Dependency in Spatial Omics Data" @default.
- W4307588226 cites W143236119 @default.
- W4307588226 cites W1965092590 @default.
- W4307588226 cites W1985987855 @default.
- W4307588226 cites W1993273815 @default.
- W4307588226 cites W2004014822 @default.
- W4307588226 cites W2007472330 @default.
- W4307588226 cites W2055045309 @default.
- W4307588226 cites W2074682976 @default.
- W4307588226 cites W2099741732 @default.
- W4307588226 cites W2471536144 @default.
- W4307588226 cites W2519132385 @default.
- W4307588226 cites W2785607024 @default.
- W4307588226 cites W2800392236 @default.
- W4307588226 cites W2892719209 @default.
- W4307588226 cites W2901677030 @default.
- W4307588226 cites W2916020270 @default.
- W4307588226 cites W2953866345 @default.
- W4307588226 cites W3045004532 @default.
- W4307588226 cites W3092450854 @default.
- W4307588226 cites W3108118546 @default.
- W4307588226 cites W3112563877 @default.
- W4307588226 cites W3126958162 @default.
- W4307588226 cites W3127422037 @default.
- W4307588226 cites W3129476455 @default.
- W4307588226 cites W3134482219 @default.
- W4307588226 cites W3141239155 @default.
- W4307588226 cites W3161009639 @default.
- W4307588226 cites W3164692211 @default.
- W4307588226 cites W3165120573 @default.
- W4307588226 cites W3170315684 @default.
- W4307588226 cites W3174072032 @default.
- W4307588226 cites W3176766013 @default.
- W4307588226 cites W3190202966 @default.
- W4307588226 cites W3193419934 @default.
- W4307588226 cites W3198511950 @default.
- W4307588226 cites W3217269355 @default.
- W4307588226 cites W4205817967 @default.
- W4307588226 cites W4206199829 @default.
- W4307588226 cites W4210410309 @default.
- W4307588226 cites W4210583065 @default.
- W4307588226 cites W4210587306 @default.
- W4307588226 cites W4211162540 @default.
- W4307588226 cites W4221064218 @default.
- W4307588226 cites W4224218779 @default.
- W4307588226 cites W4225272983 @default.
- W4307588226 cites W4225598893 @default.
- W4307588226 cites W4226192560 @default.
- W4307588226 cites W4236889246 @default.
- W4307588226 cites W4284893339 @default.
- W4307588226 cites W4285388882 @default.
- W4307588226 cites W4286005528 @default.
- W4307588226 cites W4289956737 @default.
- W4307588226 cites W4291291938 @default.
- W4307588226 cites W4292121951 @default.
- W4307588226 cites W4293692947 @default.
- W4307588226 cites W4308989306 @default.
- W4307588226 cites W4319072106 @default.
- W4307588226 cites W4319440743 @default.
- W4307588226 cites W4321112079 @default.
- W4307588226 cites W4384830693 @default.
- W4307588226 doi "https://doi.org/10.1101/2022.10.25.513785" @default.
- W4307588226 hasPublicationYear "2022" @default.
- W4307588226 type Work @default.
- W4307588226 citedByCount "1" @default.
- W4307588226 countsByYear W43075882262022 @default.
- W4307588226 crossrefType "posted-content" @default.
- W4307588226 hasAuthorship W4307588226A5000245536 @default.
- W4307588226 hasAuthorship W4307588226A5012226169 @default.
- W4307588226 hasAuthorship W4307588226A5013311924 @default.
- W4307588226 hasAuthorship W4307588226A5038705974 @default.
- W4307588226 hasAuthorship W4307588226A5052100404 @default.
- W4307588226 hasAuthorship W4307588226A5056128255 @default.
- W4307588226 hasAuthorship W4307588226A5067368955 @default.
- W4307588226 hasAuthorship W4307588226A5073479976 @default.
- W4307588226 hasAuthorship W4307588226A5081351428 @default.
- W4307588226 hasAuthorship W4307588226A5085310630 @default.
- W4307588226 hasBestOaLocation W43075882261 @default.
- W4307588226 hasConcept C101468663 @default.
- W4307588226 hasConcept C105795698 @default.
- W4307588226 hasConcept C111919701 @default.
- W4307588226 hasConcept C11413529 @default.
- W4307588226 hasConcept C119857082 @default.
- W4307588226 hasConcept C124101348 @default.
- W4307588226 hasConcept C154945302 @default.
- W4307588226 hasConcept C159620131 @default.