Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307642505> ?p ?o ?g. }
- W4307642505 abstract "Abstract Background A significant percentage of methamphetamine (MA) dependent patients develop psychosis. However, the associations between oxidative pathways and MA-induced psychosis (MIP) are not well delineated. Objective The aim of this study is to delineate whether acute MA intoxication in MA dependent patients is accompanied by increased nitro-oxidative stress and whether the latter is associated with MIP. Method We recruited 30 healthy males and 60 acutely intoxicated MA males with MA dependence and assessed severity of MA use and dependence and psychotic symptoms during intoxication and measured serum oxidative toxicity (OSTOX) biomarkers including oxidized high (oxHDL) and low (oxLDL)-density lipoprotein, myeloperoxidase (MPO), malondialdehyde (MDA), and nitric oxide (NO), and antioxidant defenses (ANTIOX) including HDL-cholesterol, zinc, glutathione peroxidase (GPx), total antioxidant capacity (TAC), and catalase-1. Results A large part (50%, n=30) of patients with MA dependence could be allocated to a cluster characterized by high psychosis ratings including delusions, suspiciousness, conceptual disorganization and difficulties abstract thinking and an increased OSTOX/ANTIOX ratio. Partial Least Squares analysis showed that 29.9% of the variance in MIP severity (a first factor extracted from psychosis, hostility, excitation, mannerism, and formal thought disorder scores) was explained by HDL, TAC and zinc (all inversely) and oxLDL (positively). MA dependence and dosing explained together 44.7% of the variance in the OSTOX/ANTIOX ratio. Conclusion MA dependence and intoxication are associated with increased oxidative stress and lowered antioxidant defenses, which both increase risk of MIP during acute intoxication. MA dependence is accompanied by increased atherogenicity due to lowered HDL and increased oxLDL and oxHDL." @default.
- W4307642505 created "2022-11-04" @default.
- W4307642505 creator A5000646126 @default.
- W4307642505 creator A5019872290 @default.
- W4307642505 creator A5047175376 @default.
- W4307642505 creator A5051970614 @default.
- W4307642505 creator A5081924790 @default.
- W4307642505 date "2022-10-30" @default.
- W4307642505 modified "2023-09-24" @default.
- W4307642505 title "Increased lipid peroxidation and lowered antioxidant defenses predict methamphetamine induced psychosis" @default.
- W4307642505 cites W1569512646 @default.
- W4307642505 cites W1595134555 @default.
- W4307642505 cites W1606698275 @default.
- W4307642505 cites W1611362056 @default.
- W4307642505 cites W1627116792 @default.
- W4307642505 cites W1627935689 @default.
- W4307642505 cites W1935545126 @default.
- W4307642505 cites W1975812147 @default.
- W4307642505 cites W1988937453 @default.
- W4307642505 cites W1993510264 @default.
- W4307642505 cites W1994147604 @default.
- W4307642505 cites W2001607741 @default.
- W4307642505 cites W2011854518 @default.
- W4307642505 cites W2020844317 @default.
- W4307642505 cites W2035893127 @default.
- W4307642505 cites W2041055523 @default.
- W4307642505 cites W2047068638 @default.
- W4307642505 cites W2056425055 @default.
- W4307642505 cites W2056704543 @default.
- W4307642505 cites W2062042157 @default.
- W4307642505 cites W2068311250 @default.
- W4307642505 cites W2072839634 @default.
- W4307642505 cites W2084240094 @default.
- W4307642505 cites W2084843232 @default.
- W4307642505 cites W2088701344 @default.
- W4307642505 cites W2102393059 @default.
- W4307642505 cites W2102698621 @default.
- W4307642505 cites W2117792476 @default.
- W4307642505 cites W2124525963 @default.
- W4307642505 cites W2128883244 @default.
- W4307642505 cites W2131891666 @default.
- W4307642505 cites W2132052187 @default.
- W4307642505 cites W2132552191 @default.
- W4307642505 cites W2140606211 @default.
- W4307642505 cites W2140998385 @default.
- W4307642505 cites W2150686721 @default.
- W4307642505 cites W2160783512 @default.
- W4307642505 cites W2168175864 @default.
- W4307642505 cites W2210219816 @default.
- W4307642505 cites W2261793840 @default.
- W4307642505 cites W2343855628 @default.
- W4307642505 cites W2466796039 @default.
- W4307642505 cites W2595992673 @default.
- W4307642505 cites W2601087407 @default.
- W4307642505 cites W2743492588 @default.
- W4307642505 cites W2767434766 @default.
- W4307642505 cites W2784962315 @default.
- W4307642505 cites W2792521021 @default.
- W4307642505 cites W2804353816 @default.
- W4307642505 cites W2884398032 @default.
- W4307642505 cites W2892238272 @default.
- W4307642505 cites W2896027820 @default.
- W4307642505 cites W2896626354 @default.
- W4307642505 cites W2914794955 @default.
- W4307642505 cites W2949542417 @default.
- W4307642505 cites W2953065795 @default.
- W4307642505 cites W2960375451 @default.
- W4307642505 cites W2964673981 @default.
- W4307642505 cites W2969628213 @default.
- W4307642505 cites W2993797302 @default.
- W4307642505 cites W3000017005 @default.
- W4307642505 cites W3000670836 @default.
- W4307642505 cites W3004840704 @default.
- W4307642505 cites W3010870729 @default.
- W4307642505 cites W3019678451 @default.
- W4307642505 cites W3047403558 @default.
- W4307642505 cites W3087614348 @default.
- W4307642505 cites W3110753138 @default.
- W4307642505 cites W3164102867 @default.
- W4307642505 cites W3199254314 @default.
- W4307642505 cites W3199285572 @default.
- W4307642505 cites W3211847820 @default.
- W4307642505 cites W4206450376 @default.
- W4307642505 cites W4226075339 @default.
- W4307642505 cites W4235985820 @default.
- W4307642505 cites W4247665917 @default.
- W4307642505 cites W4281971673 @default.
- W4307642505 cites W4285170928 @default.
- W4307642505 cites W4295898652 @default.
- W4307642505 cites W4306711183 @default.
- W4307642505 doi "https://doi.org/10.1101/2022.10.26.22281566" @default.
- W4307642505 hasPublicationYear "2022" @default.
- W4307642505 type Work @default.
- W4307642505 citedByCount "0" @default.
- W4307642505 crossrefType "posted-content" @default.
- W4307642505 hasAuthorship W4307642505A5000646126 @default.
- W4307642505 hasAuthorship W4307642505A5019872290 @default.
- W4307642505 hasAuthorship W4307642505A5047175376 @default.
- W4307642505 hasAuthorship W4307642505A5051970614 @default.
- W4307642505 hasAuthorship W4307642505A5081924790 @default.