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- W4307657652 abstract "Abstract The major histocompatibility complex (MHC) is a group of genes comprising one of the most important components of the vertebrate immune system. Consequently, there has been much interest in characterising MHC variation and its relationship with fitness in a variety of species. Due to the exceptional polymorphism of MHC genes, careful PCR primer design is crucial for capturing all of the allelic variation present in a given species. We therefore developed intronic primers to amplify the full-length 267 bp protein-coding sequence of the MHC class II DQB exon 2 in the Antarctic fur seal. We then characterised patterns of MHC variation among mother–offspring pairs from two breeding colonies and detected 19 alleles among 771 clone sequences from 56 individuals. The distribution of alleles within and among individuals was consistent with a single-copy, classical DQB locus showing Mendelian inheritance. Amino acid similarity at the MHC was significantly associated with genome-wide relatedness, but no relationship was found between MHC heterozygosity and genome-wide heterozygosity. Finally, allelic diversity was several times higher than reported by a previous study based on partial exon sequences. This difference appears to be related to allele-specific amplification bias, implying that primer design can strongly impact the inference of MHC diversity." @default.
- W4307657652 created "2022-11-04" @default.
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- W4307657652 date "2022-10-26" @default.
- W4307657652 modified "2023-10-17" @default.
- W4307657652 title "Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals" @default.
- W4307657652 cites W1599660769 @default.
- W4307657652 cites W1652383174 @default.
- W4307657652 cites W1673112447 @default.
- W4307657652 cites W1914145616 @default.
- W4307657652 cites W1965985952 @default.
- W4307657652 cites W1988897949 @default.
- W4307657652 cites W1989841410 @default.
- W4307657652 cites W1994005727 @default.
- W4307657652 cites W1997476591 @default.
- W4307657652 cites W2002453728 @default.
- W4307657652 cites W2002587842 @default.
- W4307657652 cites W2006337677 @default.
- W4307657652 cites W2010132710 @default.
- W4307657652 cites W2017166140 @default.
- W4307657652 cites W2020469275 @default.
- W4307657652 cites W2024598432 @default.
- W4307657652 cites W2025123278 @default.
- W4307657652 cites W2027450592 @default.
- W4307657652 cites W2037093044 @default.
- W4307657652 cites W2039879039 @default.
- W4307657652 cites W2045298201 @default.
- W4307657652 cites W2050555578 @default.
- W4307657652 cites W2051331361 @default.
- W4307657652 cites W2057888649 @default.
- W4307657652 cites W2066261119 @default.
- W4307657652 cites W2069906102 @default.
- W4307657652 cites W2073621589 @default.
- W4307657652 cites W2080956086 @default.
- W4307657652 cites W2081436187 @default.
- W4307657652 cites W2085067391 @default.
- W4307657652 cites W2097283546 @default.
- W4307657652 cites W2097834336 @default.
- W4307657652 cites W2098073190 @default.
- W4307657652 cites W2098901264 @default.
- W4307657652 cites W2099329037 @default.
- W4307657652 cites W2100327440 @default.
- W4307657652 cites W2100957776 @default.
- W4307657652 cites W2101969639 @default.
- W4307657652 cites W2106705172 @default.
- W4307657652 cites W2108434896 @default.
- W4307657652 cites W2110212983 @default.
- W4307657652 cites W2113795788 @default.
- W4307657652 cites W2114888814 @default.
- W4307657652 cites W2121344591 @default.
- W4307657652 cites W2126121566 @default.
- W4307657652 cites W2127646235 @default.
- W4307657652 cites W2130783116 @default.
- W4307657652 cites W2131098197 @default.
- W4307657652 cites W2135176175 @default.
- W4307657652 cites W2135497630 @default.
- W4307657652 cites W2136579702 @default.
- W4307657652 cites W2137270049 @default.
- W4307657652 cites W2137303277 @default.
- W4307657652 cites W2146290595 @default.
- W4307657652 cites W2150051723 @default.
- W4307657652 cites W2155289871 @default.
- W4307657652 cites W2155408399 @default.
- W4307657652 cites W2157764447 @default.
- W4307657652 cites W2160807401 @default.
- W4307657652 cites W2162098634 @default.
- W4307657652 cites W2163200827 @default.
- W4307657652 cites W2163250554 @default.
- W4307657652 cites W2164605234 @default.
- W4307657652 cites W2165725065 @default.
- W4307657652 cites W2169029547 @default.
- W4307657652 cites W2170320224 @default.
- W4307657652 cites W2171318815 @default.
- W4307657652 cites W2176191850 @default.
- W4307657652 cites W2184418667 @default.
- W4307657652 cites W2202552418 @default.
- W4307657652 cites W2235320379 @default.
- W4307657652 cites W2257392058 @default.
- W4307657652 cites W2311203695 @default.
- W4307657652 cites W2403100884 @default.
- W4307657652 cites W2430993800 @default.
- W4307657652 cites W2594373991 @default.
- W4307657652 cites W2686732860 @default.
- W4307657652 cites W2768344671 @default.
- W4307657652 cites W2796016604 @default.
- W4307657652 cites W2921764979 @default.
- W4307657652 cites W2938814701 @default.
- W4307657652 cites W2950462180 @default.
- W4307657652 cites W3004537277 @default.
- W4307657652 cites W3010954421 @default.
- W4307657652 cites W3034426569 @default.
- W4307657652 cites W3137315621 @default.