FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307680794> ?p ?o ?g. }

• W4307680794 abstract "Diabetes mellitus (DM) is now recognized as a system-wide, autoimmune, inflammatory, microvascular disorder, which, in the retina and brain results in severe multifocal injury now recognized as a leading cause, world-wide, of progressive vision loss and dementia. To address this problem, resulting primarily from variations in glycemia in the prediabetic and overt diabetic states, it must be realized that, although some of the injury processes associated with diabetes may be system wide, there are varying responses, effector, and repair mechanisms that differ from organ to organ or within varying cell structures. Specifically, within the retina, and similarly within the brain cortex, lesions occur of the “neurovascular unit”, comprised of focal microvascular occlusions, inflammatory endothelial and pericyte injury, with small vessel leakage resulting in injury to astrocytes, Müller cells, and microglia, all of which occur with progressive neuronal apoptosis. Such lesions are now recognized to occur before the first microaneurysms are visible to imaging by fundus cameras or before they result in detectable symptoms or signs recognizable to the patient or clinician. Treatments, therefore, which currently are not initiated within the retina until edema develops or there is progression of vascular lesions that define the current staging of retinopathy, and in the brain only after severe signs of cognitive failure. Treatments, therefore are applied relatively late with some reduction in progressive cellular injury but with resultant minimal vision or cognitive improvement. This review article will summarize the multiple inflammatory and remediation processes currently understood to occur in patients with diabetes as well as pre-diabetes and summarize as well the current limitations of methods for assessing the structural and functional alterations within the retina and brain. The goal is to attempt to define future screening, monitoring, and treatment directions that hopefully will prevent progressive injury as well as enable improved repair and attendant function." @default.
• W4307680794 created "2022-11-04" @default.
• W4307680794 creator A5007452437 @default.
• W4307680794 creator A5014723086 @default.
• W4307680794 creator A5015509938 @default.
• W4307680794 creator A5064811472 @default.
• W4307680794 date "2022-10-31" @default.
• W4307680794 modified "2023-10-14" @default.
• W4307680794 title "Diabetes mellitus associated neurovascular lesions in the retina and brain: A review" @default.
• W4307680794 cites W149532486 @default.
• W4307680794 cites W1507364611 @default.
• W4307680794 cites W1512487996 @default.
• W4307680794 cites W1529114455 @default.
• W4307680794 cites W1539599110 @default.
• W4307680794 cites W1585041418 @default.
• W4307680794 cites W1782108791 @default.
• W4307680794 cites W1786299986 @default.
• W4307680794 cites W1895408795 @default.
• W4307680794 cites W1963594829 @default.
• W4307680794 cites W1963773184 @default.
• W4307680794 cites W1964445339 @default.
• W4307680794 cites W1965942744 @default.
• W4307680794 cites W1966206262 @default.
• W4307680794 cites W1966985136 @default.
• W4307680794 cites W1969139700 @default.
• W4307680794 cites W1972585240 @default.
• W4307680794 cites W1973198111 @default.
• W4307680794 cites W1973834502 @default.
• W4307680794 cites W1973945718 @default.
• W4307680794 cites W1974373780 @default.
• W4307680794 cites W1974997758 @default.
• W4307680794 cites W1976481038 @default.
• W4307680794 cites W1978348555 @default.
• W4307680794 cites W1980335514 @default.
• W4307680794 cites W1980610697 @default.
• W4307680794 cites W1981602494 @default.
• W4307680794 cites W1982505361 @default.
• W4307680794 cites W1982523336 @default.
• W4307680794 cites W1985106059 @default.
• W4307680794 cites W1985403743 @default.
• W4307680794 cites W1986266598 @default.
• W4307680794 cites W1989034945 @default.
• W4307680794 cites W1990495332 @default.
• W4307680794 cites W1992103610 @default.
• W4307680794 cites W1992553297 @default.
• W4307680794 cites W1993735050 @default.
• W4307680794 cites W1993970594 @default.
• W4307680794 cites W1994117565 @default.
• W4307680794 cites W1994260596 @default.
• W4307680794 cites W1995089933 @default.
• W4307680794 cites W1995904975 @default.
• W4307680794 cites W1997795808 @default.
• W4307680794 cites W1998046077 @default.
• W4307680794 cites W1998086227 @default.
• W4307680794 cites W1998850459 @default.
• W4307680794 cites W1999688174 @default.
• W4307680794 cites W2003482600 @default.
• W4307680794 cites W2006567606 @default.
• W4307680794 cites W2010044292 @default.
• W4307680794 cites W2011540186 @default.
• W4307680794 cites W2012543511 @default.
• W4307680794 cites W2016293221 @default.
• W4307680794 cites W2016829576 @default.
• W4307680794 cites W2016927144 @default.
• W4307680794 cites W2017146561 @default.
• W4307680794 cites W2021338387 @default.
• W4307680794 cites W2023455453 @default.
• W4307680794 cites W2024378513 @default.
• W4307680794 cites W2025761307 @default.
• W4307680794 cites W2025833281 @default.
• W4307680794 cites W2026166234 @default.
• W4307680794 cites W2028254185 @default.
• W4307680794 cites W2032105712 @default.
• W4307680794 cites W2033547694 @default.
• W4307680794 cites W2033617297 @default.
• W4307680794 cites W2033632929 @default.
• W4307680794 cites W2034384804 @default.
• W4307680794 cites W2034671535 @default.
• W4307680794 cites W2034722240 @default.
• W4307680794 cites W2035590629 @default.
• W4307680794 cites W2036091553 @default.
• W4307680794 cites W2036903078 @default.
• W4307680794 cites W2039517564 @default.
• W4307680794 cites W2039752037 @default.
• W4307680794 cites W2041092286 @default.
• W4307680794 cites W2042050327 @default.
• W4307680794 cites W2043618136 @default.
• W4307680794 cites W2044437167 @default.
• W4307680794 cites W2044628808 @default.
• W4307680794 cites W2045324717 @default.
• W4307680794 cites W2045846363 @default.
• W4307680794 cites W2046481610 @default.
• W4307680794 cites W2047094134 @default.
• W4307680794 cites W2051741825 @default.
• W4307680794 cites W2053290690 @default.
• W4307680794 cites W2054692171 @default.
• W4307680794 cites W2054985387 @default.
• W4307680794 cites W2057397568 @default.
• W4307680794 cites W2057444974 @default.
• W4307680794 cites W2059140614 @default.

• next