Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307689969> ?p ?o ?g. }
- W4307689969 abstract "Abstract Aging is a major risk factor to develop neurodegenerative diseases and is associated with decreased buffering capacity of the proteostasis network. We investigated the significance of the unfolded protein response (UPR), a major signaling pathway activated to cope with endoplasmic reticulum (ER) stress, in the functional deterioration of the mammalian brain during aging. We report that genetic disruption of the ER stress sensor IRE1 accelerated age‐related cognitive decline. In mouse models, overexpressing an active form of the UPR transcription factor XBP1 restored synaptic and cognitive function, in addition to reducing cell senescence. Proteomic profiling of hippocampal tissue showed that XBP1 expression significantly restore changes associated with aging, including factors involved in synaptic function and pathways linked to neurodegenerative diseases. The genes modified by XBP1 in the aged hippocampus where also altered. Collectively, our results demonstrate that strategies to manipulate the UPR in mammals may help sustain healthy brain aging." @default.
- W4307689969 created "2022-11-05" @default.
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- W4307689969 date "2022-10-31" @default.
- W4307689969 modified "2023-10-18" @default.
- W4307689969 title "Unfolded protein response <scp>IRE1</scp>/<scp>XBP1</scp> signaling is required for healthy mammalian brain aging" @default.
- W4307689969 cites W1537691457 @default.
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- W4307689969 cites W1977603207 @default.
- W4307689969 cites W1980361506 @default.
- W4307689969 cites W1981515291 @default.
- W4307689969 cites W1983509957 @default.
- W4307689969 cites W1984518531 @default.
- W4307689969 cites W2003755766 @default.
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- W4307689969 cites W2021727296 @default.
- W4307689969 cites W2022689242 @default.
- W4307689969 cites W2033884290 @default.
- W4307689969 cites W2034632760 @default.
- W4307689969 cites W2037911961 @default.
- W4307689969 cites W2040501521 @default.
- W4307689969 cites W2041996284 @default.
- W4307689969 cites W2044099793 @default.
- W4307689969 cites W2046755890 @default.
- W4307689969 cites W2048445545 @default.
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- W4307689969 cites W2053500970 @default.
- W4307689969 cites W2059404699 @default.
- W4307689969 cites W2094118946 @default.
- W4307689969 cites W2103795148 @default.
- W4307689969 cites W2105699709 @default.
- W4307689969 cites W2107401866 @default.
- W4307689969 cites W2110599341 @default.
- W4307689969 cites W2114926230 @default.
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- W4307689969 cites W2126525177 @default.
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- W4307689969 cites W2136597136 @default.
- W4307689969 cites W2136626461 @default.
- W4307689969 cites W2140400644 @default.
- W4307689969 cites W2144063270 @default.
- W4307689969 cites W2152217159 @default.
- W4307689969 cites W2153529164 @default.
- W4307689969 cites W2159914115 @default.
- W4307689969 cites W2198998046 @default.
- W4307689969 cites W2255156876 @default.
- W4307689969 cites W2263774645 @default.
- W4307689969 cites W2302641769 @default.
- W4307689969 cites W2322024246 @default.
- W4307689969 cites W2325038472 @default.
- W4307689969 cites W2343412000 @default.
- W4307689969 cites W2345356016 @default.
- W4307689969 cites W2386603878 @default.
- W4307689969 cites W2476887811 @default.
- W4307689969 cites W2534083405 @default.
- W4307689969 cites W2549006896 @default.
- W4307689969 cites W2597882562 @default.
- W4307689969 cites W2606642562 @default.
- W4307689969 cites W2612475180 @default.
- W4307689969 cites W2732353044 @default.
- W4307689969 cites W2738794221 @default.
- W4307689969 cites W2756266663 @default.
- W4307689969 cites W2772926575 @default.
- W4307689969 cites W2789191208 @default.
- W4307689969 cites W2793107637 @default.
- W4307689969 cites W2811033924 @default.
- W4307689969 cites W2883018157 @default.
- W4307689969 cites W2890247534 @default.
- W4307689969 cites W2899760200 @default.