Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307698916> ?p ?o ?g. }
- W4307698916 endingPage "e0010688" @default.
- W4307698916 startingPage "e0010688" @default.
- W4307698916 abstract "Trypanosoma cruzi naturally infects a wide variety of wild and domesticated mammals, in addition to humans. Depending on the infection dose and other factors, the acute infection can be life-threatening, and in all cases, the risk of chagasic heart disease is high in persistently infected hosts. Domestic, working, and semi-feral dogs in the Americas are at significant risk of T. cruzi infection and in certain settings in the southern United States, the risk of new infections can exceed 30% per year, even with the use of vector control protocols. In this study, we explored whether intermittent low-dose treatment with the trypanocidal compound benznidazole (BNZ) during the transmission season, could alter the number of new infections in dogs in an area of known, intense transmission pressure. Preliminary studies in mice suggested that twice-weekly administration of BNZ could prevent or truncate infections when parasites were delivered at the mid-point between BNZ doses. Pre-transmission season screening of 126 dogs identified 53 dogs (42.1%) as T. cruzi infection positive, based upon blood PCR and Luminex-based serology. Serial monitoring of the 67 uninfected dogs during the high transmission season (May to October) revealed 15 (22.4%) new infections, 6 in the untreated control group and 9 in the group receiving BNZ prophylaxis, indicating no impact of this prophylaxis regimen on the incidence of new infections. Although these studies suggest that rigorously timed and more potent dosing regimen may be needed to achieve an immediate benefit of prophylaxis, additional studies would be needed to determine if drug prophylaxis reduced disease severity despite this failure to prevent new infections." @default.
- W4307698916 created "2022-11-05" @default.
- W4307698916 creator A5019095750 @default.
- W4307698916 creator A5021553726 @default.
- W4307698916 creator A5023992420 @default.
- W4307698916 creator A5030385023 @default.
- W4307698916 creator A5032013018 @default.
- W4307698916 creator A5043927269 @default.
- W4307698916 creator A5061509734 @default.
- W4307698916 creator A5064310918 @default.
- W4307698916 creator A5078570899 @default.
- W4307698916 creator A5079023613 @default.
- W4307698916 creator A5087527057 @default.
- W4307698916 date "2022-10-31" @default.
- W4307698916 modified "2023-10-01" @default.
- W4307698916 title "Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure" @default.
- W4307698916 cites W1738445104 @default.
- W4307698916 cites W1906778669 @default.
- W4307698916 cites W1965237012 @default.
- W4307698916 cites W1989571419 @default.
- W4307698916 cites W1992778950 @default.
- W4307698916 cites W2018749887 @default.
- W4307698916 cites W2020087523 @default.
- W4307698916 cites W2026148579 @default.
- W4307698916 cites W2028926742 @default.
- W4307698916 cites W2049991241 @default.
- W4307698916 cites W2055724622 @default.
- W4307698916 cites W2058484100 @default.
- W4307698916 cites W2064216140 @default.
- W4307698916 cites W2067441673 @default.
- W4307698916 cites W2101508035 @default.
- W4307698916 cites W2102260583 @default.
- W4307698916 cites W2119509691 @default.
- W4307698916 cites W2141443728 @default.
- W4307698916 cites W2145205492 @default.
- W4307698916 cites W2147087372 @default.
- W4307698916 cites W2148282769 @default.
- W4307698916 cites W2153929707 @default.
- W4307698916 cites W2156129639 @default.
- W4307698916 cites W2157643399 @default.
- W4307698916 cites W2211498717 @default.
- W4307698916 cites W2574950577 @default.
- W4307698916 cites W2598622203 @default.
- W4307698916 cites W2735664081 @default.
- W4307698916 cites W2782374108 @default.
- W4307698916 cites W2790168058 @default.
- W4307698916 cites W2946165070 @default.
- W4307698916 cites W2954985664 @default.
- W4307698916 cites W2957659204 @default.
- W4307698916 cites W3036655543 @default.
- W4307698916 cites W3047598374 @default.
- W4307698916 cites W3067761469 @default.
- W4307698916 cites W3097226423 @default.
- W4307698916 cites W3129549356 @default.
- W4307698916 cites W3143958602 @default.
- W4307698916 cites W3212144022 @default.
- W4307698916 cites W3214717405 @default.
- W4307698916 doi "https://doi.org/10.1371/journal.pntd.0010688" @default.
- W4307698916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36315597" @default.
- W4307698916 hasPublicationYear "2022" @default.
- W4307698916 type Work @default.
- W4307698916 citedByCount "7" @default.
- W4307698916 countsByYear W43076989162022 @default.
- W4307698916 countsByYear W43076989162023 @default.
- W4307698916 crossrefType "journal-article" @default.
- W4307698916 hasAuthorship W4307698916A5019095750 @default.
- W4307698916 hasAuthorship W4307698916A5021553726 @default.
- W4307698916 hasAuthorship W4307698916A5023992420 @default.
- W4307698916 hasAuthorship W4307698916A5030385023 @default.
- W4307698916 hasAuthorship W4307698916A5032013018 @default.
- W4307698916 hasAuthorship W4307698916A5043927269 @default.
- W4307698916 hasAuthorship W4307698916A5061509734 @default.
- W4307698916 hasAuthorship W4307698916A5064310918 @default.
- W4307698916 hasAuthorship W4307698916A5078570899 @default.
- W4307698916 hasAuthorship W4307698916A5079023613 @default.
- W4307698916 hasAuthorship W4307698916A5087527057 @default.
- W4307698916 hasBestOaLocation W43076989161 @default.
- W4307698916 hasConcept C112418997 @default.
- W4307698916 hasConcept C119599485 @default.
- W4307698916 hasConcept C120665830 @default.
- W4307698916 hasConcept C121332964 @default.
- W4307698916 hasConcept C126322002 @default.
- W4307698916 hasConcept C127413603 @default.
- W4307698916 hasConcept C136764020 @default.
- W4307698916 hasConcept C159654299 @default.
- W4307698916 hasConcept C203014093 @default.
- W4307698916 hasConcept C2776171842 @default.
- W4307698916 hasConcept C2777625466 @default.
- W4307698916 hasConcept C2781413609 @default.
- W4307698916 hasConcept C41008148 @default.
- W4307698916 hasConcept C42972112 @default.
- W4307698916 hasConcept C45189115 @default.
- W4307698916 hasConcept C61511704 @default.
- W4307698916 hasConcept C71924100 @default.
- W4307698916 hasConcept C71928629 @default.
- W4307698916 hasConcept C761482 @default.
- W4307698916 hasConcept C86803240 @default.
- W4307698916 hasConceptScore W4307698916C112418997 @default.