FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307706640> ?p ?o ?g. }

• W4307706640 abstract "Background and objective: Idiopathic pulmonary fibrosis (IPF) is a critical disease, with limited treatments available. Clinical practices show that traditional Chinese medicine (TCM) has certain efficacy. This study was preliminarily to evaluate the efficacy and safety of TCM treatment based on syndrome differentiation in IPF. Methods: A study design of exploratory, multi-centers, randomized, double-blinded, placebo controlled trial has been adopted. A total of 80 IPF patients from four sub-centers were enrolled. All the patients were randomly assigned into TCM group (TCMG) or control group (CG) in 1:1. Patients in TCMG were given CM granules, as patients in CG given with the placebo of CM granule. All the patients received a 26-week treatment. The efficacy was assessed by acute exacerbations (AEs) of IPF, pulmonary function, clinical symptoms, dyspnea scores (mMRC), health-related quality of life (HRQoL), 6-min walk test (6MWT) and all-cause mortality. Safety has also been assessed. Results: A total of 67 patients completed the trial with 35 in TCM group and 32 in control group. Meaningful differences have been observed in mean changes in AEs (−1.56 times; 95% CI, −2.69 to −0.43, p = 0.01), DLco% (5.29; 95% CI, 0.76 to 9.81, p = 0.02), cough scores (−0.38 points; 95% CI, −0.73 to −0.04, p = 0.03), and 6MWT (30.43 m; 95% CI, 2.85 to 58.00, p = 0.03), with no statistical differences in FEV1, FVC, expectoration, chest tightness, Shortness of breath, Fatigue, Cyanosis, mMRC, CAT, SF-36, and SGRQ total scores in 26 weeks after treatment than before treatment. At of the end of follow-up, a total of 10 patients died, including three and seven in the TCM and control group respectively. And the HR (Hazard ratio) for CM granules in all-cause mortality was 0.39 (95% CI, 0.10–1.52). The drug-related adverse events were not observed. Conclusion: CM granules, as compared with placebo, could reduce frequencies of AEs, improve pulmonary function, HRQoL, exercise capacity and symptoms and signs for IPF to some extent with acceptable side-effect." @default.
• W4307706640 created "2022-11-05" @default.
• W4307706640 creator A5005975071 @default.
• W4307706640 creator A5015741830 @default.
• W4307706640 creator A5021205649 @default.
• W4307706640 creator A5026564279 @default.
• W4307706640 creator A5030693092 @default.
• W4307706640 creator A5044364430 @default.
• W4307706640 creator A5072736879 @default.
• W4307706640 date "2022-10-28" @default.
• W4307706640 modified "2023-09-28" @default.
• W4307706640 title "Efficacy and safety of traditional Chinese medicine treatment for idiopathic pulmonary fibrosis: An exploratory, randomized, double-blinded and placebo controlled trial" @default.
• W4307706640 cites W1938547050 @default.
• W4307706640 cites W1970008616 @default.
• W4307706640 cites W1984774336 @default.
• W4307706640 cites W2117885404 @default.
• W4307706640 cites W2118894860 @default.
• W4307706640 cites W2131944618 @default.
• W4307706640 cites W2135577046 @default.
• W4307706640 cites W2138871107 @default.
• W4307706640 cites W2167383172 @default.
• W4307706640 cites W2168666423 @default.
• W4307706640 cites W2226107176 @default.
• W4307706640 cites W2233685176 @default.
• W4307706640 cites W2271417060 @default.
• W4307706640 cites W2394621964 @default.
• W4307706640 cites W2440054067 @default.
• W4307706640 cites W2464057795 @default.
• W4307706640 cites W2602828621 @default.
• W4307706640 cites W2737655507 @default.
• W4307706640 cites W2755622130 @default.
• W4307706640 cites W2763113350 @default.
• W4307706640 cites W2770299670 @default.
• W4307706640 cites W2810897494 @default.
• W4307706640 cites W2896795944 @default.
• W4307706640 cites W2922179472 @default.
• W4307706640 cites W2945205783 @default.
• W4307706640 cites W2953047026 @default.
• W4307706640 cites W2998574669 @default.
• W4307706640 cites W3126348367 @default.
• W4307706640 cites W3180817155 @default.
• W4307706640 cites W4200133893 @default.
• W4307706640 cites W4206107426 @default.
• W4307706640 cites W4211080098 @default.
• W4307706640 cites W4225403198 @default.
• W4307706640 doi "https://doi.org/10.3389/fphar.2022.1053356" @default.
• W4307706640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36386223" @default.
• W4307706640 hasPublicationYear "2022" @default.
• W4307706640 type Work @default.
• W4307706640 citedByCount "1" @default.
• W4307706640 countsByYear W43077066402023 @default.
• W4307706640 crossrefType "journal-article" @default.
• W4307706640 hasAuthorship W4307706640A5005975071 @default.
• W4307706640 hasAuthorship W4307706640A5015741830 @default.
• W4307706640 hasAuthorship W4307706640A5021205649 @default.
• W4307706640 hasAuthorship W4307706640A5026564279 @default.
• W4307706640 hasAuthorship W4307706640A5030693092 @default.
• W4307706640 hasAuthorship W4307706640A5044364430 @default.
• W4307706640 hasAuthorship W4307706640A5072736879 @default.
• W4307706640 hasBestOaLocation W43077066401 @default.
• W4307706640 hasConcept C126322002 @default.
• W4307706640 hasConcept C142724271 @default.
• W4307706640 hasConcept C159110408 @default.
• W4307706640 hasConcept C16020263 @default.
• W4307706640 hasConcept C165637977 @default.
• W4307706640 hasConcept C168563851 @default.
• W4307706640 hasConcept C1862650 @default.
• W4307706640 hasConcept C188947578 @default.
• W4307706640 hasConcept C197934379 @default.
• W4307706640 hasConcept C204787440 @default.
• W4307706640 hasConcept C27081682 @default.
• W4307706640 hasConcept C2777714996 @default.
• W4307706640 hasConcept C2778341716 @default.
• W4307706640 hasConcept C2779951463 @default.
• W4307706640 hasConcept C3018587741 @default.
• W4307706640 hasConcept C535046627 @default.
• W4307706640 hasConcept C71924100 @default.
• W4307706640 hasConcept C75603125 @default.
• W4307706640 hasConceptScore W4307706640C126322002 @default.
• W4307706640 hasConceptScore W4307706640C142724271 @default.
• W4307706640 hasConceptScore W4307706640C159110408 @default.
• W4307706640 hasConceptScore W4307706640C16020263 @default.
• W4307706640 hasConceptScore W4307706640C165637977 @default.
• W4307706640 hasConceptScore W4307706640C168563851 @default.
• W4307706640 hasConceptScore W4307706640C1862650 @default.
• W4307706640 hasConceptScore W4307706640C188947578 @default.
• W4307706640 hasConceptScore W4307706640C197934379 @default.
• W4307706640 hasConceptScore W4307706640C204787440 @default.
• W4307706640 hasConceptScore W4307706640C27081682 @default.
• W4307706640 hasConceptScore W4307706640C2777714996 @default.
• W4307706640 hasConceptScore W4307706640C2778341716 @default.
• W4307706640 hasConceptScore W4307706640C2779951463 @default.
• W4307706640 hasConceptScore W4307706640C3018587741 @default.
• W4307706640 hasConceptScore W4307706640C535046627 @default.
• W4307706640 hasConceptScore W4307706640C71924100 @default.
• W4307706640 hasConceptScore W4307706640C75603125 @default.
• W4307706640 hasLocation W43077066401 @default.
• W4307706640 hasLocation W43077066402 @default.
• W4307706640 hasLocation W43077066403 @default.
• W4307706640 hasLocation W43077066404 @default.

• next