FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307726679> ?p ?o ?g. }

• W4307726679 endingPage "108413" @default.
• W4307726679 startingPage "108413" @default.
• W4307726679 abstract "Leishmania (Leishmania) infantum is the causative agent of visceral leishmaniasis, while L. (L.) amazonensis is associated with localized cutaneous and diffuse leishmaniasis, which can affect different organ tissues leading to visceral manifestations in some hosts. The wide range of clinical manifestations of leishmaniasis depends on host factors such as the immune response and on the species of Leishmania involved in the infection. Macrophages are the main infected cells in the vertebrate host, and proteins play a pivotal role in Leishmania-macrophage interactions. Here, we performed difference gel electrophoresis (DIGE) and shotgun quantitative mass spectrometry-based proteomics by means of tandem mass tags (TMT) isobaric peptide labeling followed by LC-MS/MS to investigate differentially abundant proteins in BALB/c macrophages infected with these Leishmania species. Using DIGE for comparison, we found that 2.34% spots (29/1240) were differentially intense in infected murine macrophages. Leishmania (L.) infantum and L. (L.) amazonensis induced similar changes in the host cells; 11 spots were selected as differentially intense in each species and seven in the uninfected control group. Using TMT, 5939 Mus musculus proteins were identified, of which 410 and 433 were differentially abundant in L. (L.) infantum and L. (L.) amazonensis infections, respectively, while 170 proteins were commonly regulated by both the species. Gene ontology enrichment analysis indicated that Leishmania infection interfered with apoptotic mechanisms in macrophages and induced epigenetic changes that may affect gene transcription. Moreover, downregulation of proteins such as PYCARD and MyD88 seemed to influence the inflammatory process in L. (L.) amazonensis infection, whereas upregulation of TAP1 and ERAP1 was involved in the adaptive immune response in L. (L.) infantum infection. Differentially abundant proteins identified in this study may contribute to a better understanding of the factors that determine the course of infection. Our results suggest several possible targets for vaccines, drugs, and diagnosis of leishmaniasis." @default.
• W4307726679 created "2022-11-05" @default.
• W4307726679 creator A5042571263 @default.
• W4307726679 creator A5043453536 @default.
• W4307726679 creator A5077165998 @default.
• W4307726679 creator A5084386262 @default.
• W4307726679 creator A5089302558 @default.
• W4307726679 date "2022-12-01" @default.
• W4307726679 modified "2023-10-16" @default.
• W4307726679 title "Assessing the effects of Leishmania (Leishmania) infantum and L. (L.) amazonensis infections in macrophages using a quantitative proteome approach" @default.
• W4307726679 cites W1508237796 @default.
• W4307726679 cites W1646217211 @default.
• W4307726679 cites W1964313477 @default.
• W4307726679 cites W1967006803 @default.
• W4307726679 cites W1986317813 @default.
• W4307726679 cites W1991442992 @default.
• W4307726679 cites W1997777640 @default.
• W4307726679 cites W1999202667 @default.
• W4307726679 cites W2000714888 @default.
• W4307726679 cites W2002303007 @default.
• W4307726679 cites W2002705413 @default.
• W4307726679 cites W2003801319 @default.
• W4307726679 cites W2006002292 @default.
• W4307726679 cites W2011855963 @default.
• W4307726679 cites W2012423405 @default.
• W4307726679 cites W2020930525 @default.
• W4307726679 cites W2026877058 @default.
• W4307726679 cites W2027216206 @default.
• W4307726679 cites W2034887729 @default.
• W4307726679 cites W2049361955 @default.
• W4307726679 cites W2056538642 @default.
• W4307726679 cites W2058411735 @default.
• W4307726679 cites W2063128080 @default.
• W4307726679 cites W2091789695 @default.
• W4307726679 cites W2095057717 @default.
• W4307726679 cites W2100429492 @default.
• W4307726679 cites W2100596921 @default.
• W4307726679 cites W2102328887 @default.
• W4307726679 cites W2127411000 @default.
• W4307726679 cites W2133465414 @default.
• W4307726679 cites W2147830145 @default.
• W4307726679 cites W2149267338 @default.
• W4307726679 cites W2150822739 @default.
• W4307726679 cites W2152702111 @default.
• W4307726679 cites W2154927069 @default.
• W4307726679 cites W2158217645 @default.
• W4307726679 cites W2161686218 @default.
• W4307726679 cites W2162009851 @default.
• W4307726679 cites W2296520086 @default.
• W4307726679 cites W2410589421 @default.
• W4307726679 cites W2563034400 @default.
• W4307726679 cites W2563612948 @default.
• W4307726679 cites W2612068378 @default.
• W4307726679 cites W2763769301 @default.
• W4307726679 cites W2792793299 @default.
• W4307726679 cites W2801227403 @default.
• W4307726679 cites W281102702 @default.
• W4307726679 cites W2899760200 @default.
• W4307726679 cites W2940270178 @default.
• W4307726679 cites W3119706506 @default.
• W4307726679 cites W4234588130 @default.
• W4307726679 doi "https://doi.org/10.1016/j.exppara.2022.108413" @default.
• W4307726679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36367499" @default.
• W4307726679 hasPublicationYear "2022" @default.
• W4307726679 type Work @default.
• W4307726679 citedByCount "1" @default.
• W4307726679 countsByYear W43077266792023 @default.
• W4307726679 crossrefType "journal-article" @default.
• W4307726679 hasAuthorship W4307726679A5042571263 @default.
• W4307726679 hasAuthorship W4307726679A5043453536 @default.
• W4307726679 hasAuthorship W4307726679A5077165998 @default.
• W4307726679 hasAuthorship W4307726679A5084386262 @default.
• W4307726679 hasAuthorship W4307726679A5089302558 @default.
• W4307726679 hasConcept C104317684 @default.
• W4307726679 hasConcept C104397665 @default.
• W4307726679 hasConcept C127561419 @default.
• W4307726679 hasConcept C136764020 @default.
• W4307726679 hasConcept C150194340 @default.
• W4307726679 hasConcept C162317418 @default.
• W4307726679 hasConcept C203014093 @default.
• W4307726679 hasConcept C2776555147 @default.
• W4307726679 hasConcept C2778048844 @default.
• W4307726679 hasConcept C2778689377 @default.
• W4307726679 hasConcept C2778702967 @default.
• W4307726679 hasConcept C2779121891 @default.
• W4307726679 hasConcept C2780599195 @default.
• W4307726679 hasConcept C2781092759 @default.
• W4307726679 hasConcept C2781257258 @default.
• W4307726679 hasConcept C2781371782 @default.
• W4307726679 hasConcept C3019824283 @default.
• W4307726679 hasConcept C41008148 @default.
• W4307726679 hasConcept C46111723 @default.
• W4307726679 hasConcept C54355233 @default.
• W4307726679 hasConcept C71928629 @default.
• W4307726679 hasConcept C80311884 @default.
• W4307726679 hasConcept C86153913 @default.
• W4307726679 hasConcept C86803240 @default.
• W4307726679 hasConcept C89423630 @default.

• next