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- W4307731503 abstract "Macrophages are the most abundant immune cells of the tumor microenvironment (TME) and have multiple important functions in cancer. During tumor growth, both tissue-resident macrophages and newly recruited monocyte-derived macrophages can give rise to tumor-associated macrophages (TAMs), which have been associated with poor prognosis in most cancers. Compelling evidence indicate that the high degree of plasticity of macrophages and their ability to self-renew majorly impact tumor progression and resistance to therapy. In addition, the microenvironmental factors largely affect the metabolism of macrophages and may have a major influence on TAMs proliferation and subsets functions. Thus, understanding the signaling pathways regulating TAMs self-renewal capacity may help to identify promising targets for the development of novel anticancer agents. In this review, we focus on the environmental factors that promote the capacity of macrophages to self-renew and the molecular mechanisms that govern TAMs proliferation. We also highlight the impact of tumor-derived factors on macrophages metabolism and how distinct metabolic pathways affect macrophage self-renewal." @default.
- W4307731503 created "2022-11-05" @default.
- W4307731503 creator A5006833404 @default.
- W4307731503 creator A5030079122 @default.
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- W4307731503 creator A5053217678 @default.
- W4307731503 creator A5088464340 @default.
- W4307731503 creator A5089212398 @default.
- W4307731503 date "2022-10-26" @default.
- W4307731503 modified "2023-09-30" @default.
- W4307731503 title "Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways" @default.
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