Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307771066> ?p ?o ?g. }
- W4307771066 abstract "Drug combinations and drug repurposing have emerged as promising strategies to develop novel treatments for infectious diseases, including Chagas disease. In this study, we aimed to investigate whether the repurposed drugs chloroquine (CQ) and colchicine (COL), known to inhibit Trypanosoma cruzi infection in host cells, could boost the anti- T. cruzi effect of the trypanocidal drug benznidazole (BZN), increasing its therapeutic efficacy while reducing the dose needed to eradicate the parasite. The combination of BZN and COL exhibited cytotoxicity to infected cells and low antiparasitic activity." @default.
- W4307771066 created "2022-11-05" @default.
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- W4307771066 date "2022-11-15" @default.
- W4307771066 modified "2023-10-06" @default.
- W4307771066 title "Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi <i>In Vitro</i> and <i>In Vivo</i>" @default.
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- W4307771066 doi "https://doi.org/10.1128/aac.00284-22" @default.
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