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• W4307775327 abstract "ABSTRACT HIV integration occurs in chromatin sites that favor the release of high levels of viral progeny; alternatively, the virus is also able to discreetly coexist with the host. The viral infection perturbs the cellular environment inducing the remodelling of the nuclear landscape. Indeed, HIV-1 triggers the nuclear clustering of the host factor CPSF6, but the underlying mechanism is poorly understood. Our data indicate that HIV usurps a recently discovered biological phenomenon, called liquid–liquid phase separation, to hijack the host cell. We observed CPSF6 clusters as part of HIV-induced membraneless organelles (HIV-1 MLOs) in macrophages, one of the main HIV target cell types. We describe that HIV-1 MLOs follow phase-separation rules and represent functional biomolecular condensates. We highlight HIV-1 MLOs as hubs of nuclear reverse transcription, while the double-stranded viral DNA, once formed, rapidly migrates outside these structures. Transcription-competent proviruses localize outside but near HIV-1 MLOs in LEDGF-abundant regions, known to be active chromatin sites. Therefore, HIV-1 MLOs orchestrate viral events prior to the integration step and create a favorable environment for the viral replication. This study uncovers single functional host–viral complexes in their nuclear landscape, which is markedly restructured by HIV-1." @default.
• W4307775327 created "2022-11-05" @default.
• W4307775327 creator A5004364699 @default.
• W4307775327 creator A5009293395 @default.
• W4307775327 creator A5010648059 @default.
• W4307775327 creator A5049888462 @default.
• W4307775327 creator A5068316606 @default.
• W4307775327 date "2022-10-31" @default.
• W4307775327 modified "2023-10-16" @default.
• W4307775327 title "HIV-induced membraneless organelles orchestrate post-nuclear entry steps" @default.
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