FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307777359> ?p ?o ?g. }

• W4307777359 abstract "Systemic inflammation is a hallmark of severe coronavirus disease-19 (COVID-19). Anti-inflammatory therapy is considered crucial to modulate the hyperinflammatory response (cytokine storm) in hospitalized COVID-19 patients. There is currently no specific, conclusively proven, cost-efficient, and worldwide available anti-inflammatory therapy available to treat COVID-19 patients with cytokine storm. The present study aimed to investigate the treatment benefit of oral colchicine for hospitalized COVID-19 patients with suspected cytokine storm. Colchicine is an approved drug and possesses multiple anti-inflammatory mechanisms. This was a pilot, open-label randomized controlled clinical trial comparing standard of care (SOC) plus oral colchicine (colchicine arm) vs. SOC alone (control arm) in non-ICU hospitalized COVID-19 patients with suspected cytokine storm. Colchicine treatment was initiated within first 48 hours of admission delivered at 1.5 mg loading dose, followed by 0.5 mg b.i.d. for next 6 days and 0.5 mg q.d. for the second week. A total of 96 patients were randomly allocated to the colchicine (n=48) and control groups (n=48). Both colchicine and control group patients experienced similar clinical outcomes by day 14 of hospitalization. Treatment outcome by day 14 in colchicine vs control arm: recovered and discharged alive: 36 (75.0%) vs. 37 (77.1%), remain admitted after 14-days: 4 (8.3%) vs. 5 (10.4%), ICU transferred: 4 (8.3%) vs. 3 (6.3%), and mortality: 4 (8.3%) vs. 3 (6.3%). The speed of improvement of COVID-19 acute symptoms including shortness of breath, fever, cough, the need of supplementary oxygen, and oxygen saturation level, was almost identical in the two groups. Length of hospitalization was on average 1.5 day shorter in the colchicine group. There was no evidence for a difference between the two groups in the follow-up serum levels of inflammatory biomarkers including C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), ferritin, interleukin-6 (IL-6), high-sensitivity troponin T (hs-TnT) and N-terminal pro b-type natriuretic peptide (NT pro-BNP). According to the results of our study, oral colchicine does not appear to show clinical benefits in non-ICU hospitalized COVID-19 patients with suspected cytokine storm. It is possible that the anti-inflammatory pathways of colchicine are not crucially involved in the pathogenesis of COVID-19." @default.
• W4307777359 created "2022-11-05" @default.
• W4307777359 creator A5004148815 @default.
• W4307777359 creator A5006122338 @default.
• W4307777359 creator A5010109610 @default.
• W4307777359 creator A5012965182 @default.
• W4307777359 creator A5014832853 @default.
• W4307777359 creator A5017895783 @default.
• W4307777359 creator A5019834859 @default.
• W4307777359 creator A5021856227 @default.
• W4307777359 creator A5023429097 @default.
• W4307777359 creator A5028729289 @default.
• W4307777359 creator A5036151801 @default.
• W4307777359 creator A5042600462 @default.
• W4307777359 creator A5049564157 @default.
• W4307777359 creator A5050573728 @default.
• W4307777359 creator A5050975660 @default.
• W4307777359 creator A5065801888 @default.
• W4307777359 creator A5071584000 @default.
• W4307777359 creator A5073943141 @default.
• W4307777359 creator A5075393294 @default.
• W4307777359 creator A5076156134 @default.
• W4307777359 creator A5083583542 @default.
• W4307777359 creator A5084338960 @default.
• W4307777359 creator A5091858752 @default.
• W4307777359 date "2022-06-01" @default.
• W4307777359 modified "2023-09-26" @default.
• W4307777359 title "Colchicine anti-inflammatory therapy for non-intensive care unit hospitalized COVID-19 patients: results from a pilot open-label, randomized controlled clinical trial." @default.
• W4307777359 doi "https://doi.org/10.26402/jpp.2022.3.09" @default.
• W4307777359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36302537" @default.
• W4307777359 hasPublicationYear "2022" @default.
• W4307777359 type Work @default.
• W4307777359 citedByCount "1" @default.
• W4307777359 countsByYear W43077773592023 @default.
• W4307777359 crossrefType "journal-article" @default.
• W4307777359 hasAuthorship W4307777359A5004148815 @default.
• W4307777359 hasAuthorship W4307777359A5006122338 @default.
• W4307777359 hasAuthorship W4307777359A5010109610 @default.
• W4307777359 hasAuthorship W4307777359A5012965182 @default.
• W4307777359 hasAuthorship W4307777359A5014832853 @default.
• W4307777359 hasAuthorship W4307777359A5017895783 @default.
• W4307777359 hasAuthorship W4307777359A5019834859 @default.
• W4307777359 hasAuthorship W4307777359A5021856227 @default.
• W4307777359 hasAuthorship W4307777359A5023429097 @default.
• W4307777359 hasAuthorship W4307777359A5028729289 @default.
• W4307777359 hasAuthorship W4307777359A5036151801 @default.
• W4307777359 hasAuthorship W4307777359A5042600462 @default.
• W4307777359 hasAuthorship W4307777359A5049564157 @default.
• W4307777359 hasAuthorship W4307777359A5050573728 @default.
• W4307777359 hasAuthorship W4307777359A5050975660 @default.
• W4307777359 hasAuthorship W4307777359A5065801888 @default.
• W4307777359 hasAuthorship W4307777359A5071584000 @default.
• W4307777359 hasAuthorship W4307777359A5073943141 @default.
• W4307777359 hasAuthorship W4307777359A5075393294 @default.
• W4307777359 hasAuthorship W4307777359A5076156134 @default.
• W4307777359 hasAuthorship W4307777359A5083583542 @default.
• W4307777359 hasAuthorship W4307777359A5084338960 @default.
• W4307777359 hasAuthorship W4307777359A5091858752 @default.
• W4307777359 hasConcept C126322002 @default.
• W4307777359 hasConcept C168563851 @default.
• W4307777359 hasConcept C2776376669 @default.
• W4307777359 hasConcept C2776636253 @default.
• W4307777359 hasConcept C2779134260 @default.
• W4307777359 hasConcept C2779559532 @default.
• W4307777359 hasConcept C3008058167 @default.
• W4307777359 hasConcept C524204448 @default.
• W4307777359 hasConcept C535046627 @default.
• W4307777359 hasConcept C71924100 @default.
• W4307777359 hasConceptScore W4307777359C126322002 @default.
• W4307777359 hasConceptScore W4307777359C168563851 @default.
• W4307777359 hasConceptScore W4307777359C2776376669 @default.
• W4307777359 hasConceptScore W4307777359C2776636253 @default.
• W4307777359 hasConceptScore W4307777359C2779134260 @default.
• W4307777359 hasConceptScore W4307777359C2779559532 @default.
• W4307777359 hasConceptScore W4307777359C3008058167 @default.
• W4307777359 hasConceptScore W4307777359C524204448 @default.
• W4307777359 hasConceptScore W4307777359C535046627 @default.
• W4307777359 hasConceptScore W4307777359C71924100 @default.
• W4307777359 hasIssue "3" @default.
• W4307777359 hasLocation W43077773591 @default.
• W4307777359 hasOpenAccess W4307777359 @default.
• W4307777359 hasPrimaryLocation W43077773591 @default.
• W4307777359 hasRelatedWork W1964830672 @default.
• W4307777359 hasRelatedWork W1994309295 @default.
• W4307777359 hasRelatedWork W2235574018 @default.
• W4307777359 hasRelatedWork W2406206830 @default.
• W4307777359 hasRelatedWork W2507295142 @default.
• W4307777359 hasRelatedWork W2989921235 @default.
• W4307777359 hasRelatedWork W3046800389 @default.
• W4307777359 hasRelatedWork W3047680733 @default.
• W4307777359 hasRelatedWork W4200625575 @default.
• W4307777359 hasRelatedWork W2083697902 @default.
• W4307777359 hasVolume "73" @default.
• W4307777359 isParatext "false" @default.
• W4307777359 isRetracted "false" @default.
• W4307777359 workType "article" @default.