FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307777483> ?p ?o ?g. }

• W4307777483 abstract "Abstract Background Copines‐1 (CPNE1) is a soluble membrane‐binding protein that includes two tandem C2 domains at the N‐terminus and a C terminal A domain. Importantly, it is associated with the prognosis of various tumors, but there are only a few studies regarding the role of CPNE1 in gastric cancer (GC). This study aimed to explore the clinicopathological significance and prognostic potential of CPNE1 expression in GC. Methods Data from the TIMER2.0 and UALCAN were analyzed to assess CPNE1 mRNA levels in GC. The prognostic role of CPNE1 mRNA was examined via the Kaplan–Meier plotter. CPNE1 protein expression in tumor tissues was analyzed via immunohistochemistry of clinical samples from 99 GC patients. The relationship of CPNE1 expression with clinicopathological parameters and overall survival (OS) was evaluated using Cox proportional hazards regression models and Kaplan–Meier survival curves. Results Copines‐1 mRNA levels were higher in GC tissues than in adjacent normal tissue (ANT) ( p < 0.05). Further, high CPNE1 mRNA expression indicated poor OS ( p = 9.4 e‐10) and was significantly associated with first progression (FP) ( p = 1.6 e‐06) and post‐progression survival (PPS) ( p = 1.5 e‐12). In addition, CPNE1 protein expression was higher in GC tissues than in ANT ( p < 0.0001). Moreover, CPNE1 high expression was significantly related to advanced tumor‐node‐metastasis (TNM) stage ( p = 0.004), lymph node metastasis ( p = 0.003), and vascular invasion ( p = 0.001). Kaplan–Meier analysis showed that GC patients with high expression CPNE1 group had worse OS than low expression group ( p = 0.003). Univariate analysis showed that age (hazard ratio [HR] = 1.992; 95% confidence interval [CI], 1.009–3.934; p = 0.047), advanced TNM stage (HR = 4.941; 95% CI, 2.052–11.897; p = 0.000), tumor invasion (HR = 3.472; 95% CI, 1.349–8.937; p = 0.010), lymph node metastasis (HR = 8.846; 95% CI, 2.708–28.897; p = 0.000), vascular invasion (HR = 3.237; 95% CI, 1.521–6.891; p = 0.002), nervous invasion (HR = 2.324; 95% CI, 1.205–4.479; p = 0.012), and CPNE1 expression (HR = 3.464; 95% CI, 1.440–8.334; p = 0.006) were correlated with OS. In the multivariate analysis, age (HR = 2.514; 95% CI, 1.264–4.999; p = 0.009), lymph node metastasis (HR = 8.441; 95% CI, 2.553–27.906; p < 0.05), and CPNE1 expression (HR = 2.549; 95% CI, 1.051–6.186; p = 0.039) were significant prognostic predictors for GC. Conclusions Copines‐1 overexpression in GC is significantly associated with poor prognosis. Thus, CPNE1 levels may serve as a prognostic biomarker in GC patients." @default.
• W4307777483 created "2022-11-05" @default.
• W4307777483 creator A5017995919 @default.
• W4307777483 creator A5025139860 @default.
• W4307777483 creator A5025438933 @default.
• W4307777483 creator A5031253602 @default.
• W4307777483 creator A5045149439 @default.
• W4307777483 creator A5054809100 @default.
• W4307777483 creator A5069375288 @default.
• W4307777483 date "2022-10-31" @default.
• W4307777483 modified "2023-09-26" @default.
• W4307777483 title "Overexpression of Copines‐1 is associated with clinicopathological parameters and poor outcome in gastric cancer" @default.
• W4307777483 cites W1585678344 @default.
• W4307777483 cites W2035163981 @default.
• W4307777483 cites W2049240980 @default.
• W4307777483 cites W2065209250 @default.
• W4307777483 cites W2155933329 @default.
• W4307777483 cites W2510676144 @default.
• W4307777483 cites W2578531855 @default.
• W4307777483 cites W2735126203 @default.
• W4307777483 cites W2736730167 @default.
• W4307777483 cites W2770483727 @default.
• W4307777483 cites W2775642003 @default.
• W4307777483 cites W2788857340 @default.
• W4307777483 cites W2794867971 @default.
• W4307777483 cites W2811229930 @default.
• W4307777483 cites W2889965895 @default.
• W4307777483 cites W2944525119 @default.
• W4307777483 cites W2946873995 @default.
• W4307777483 cites W3010670066 @default.
• W4307777483 cites W3027286012 @default.
• W4307777483 cites W3123227540 @default.
• W4307777483 cites W3162350134 @default.
• W4307777483 cites W3186648915 @default.
• W4307777483 cites W3211787785 @default.
• W4307777483 cites W4210614491 @default.
• W4307777483 cites W4210832856 @default.
• W4307777483 cites W4210990885 @default.
• W4307777483 cites W4211247697 @default.
• W4307777483 cites W4225845169 @default.
• W4307777483 cites W4283826594 @default.
• W4307777483 cites W4307777483 @default.
• W4307777483 doi "https://doi.org/10.1002/jcla.24744" @default.
• W4307777483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36310511" @default.
• W4307777483 hasPublicationYear "2022" @default.
• W4307777483 type Work @default.
• W4307777483 citedByCount "2" @default.
• W4307777483 countsByYear W43077774832022 @default.
• W4307777483 countsByYear W43077774832023 @default.
• W4307777483 crossrefType "journal-article" @default.
• W4307777483 hasAuthorship W4307777483A5017995919 @default.
• W4307777483 hasAuthorship W4307777483A5025139860 @default.
• W4307777483 hasAuthorship W4307777483A5025438933 @default.
• W4307777483 hasAuthorship W4307777483A5031253602 @default.
• W4307777483 hasAuthorship W4307777483A5045149439 @default.
• W4307777483 hasAuthorship W4307777483A5054809100 @default.
• W4307777483 hasAuthorship W4307777483A5069375288 @default.
• W4307777483 hasBestOaLocation W43077774831 @default.
• W4307777483 hasConcept C104317684 @default.
• W4307777483 hasConcept C10515644 @default.
• W4307777483 hasConcept C105580179 @default.
• W4307777483 hasConcept C121608353 @default.
• W4307777483 hasConcept C126322002 @default.
• W4307777483 hasConcept C142724271 @default.
• W4307777483 hasConcept C143998085 @default.
• W4307777483 hasConcept C146357865 @default.
• W4307777483 hasConcept C151730666 @default.
• W4307777483 hasConcept C204232928 @default.
• W4307777483 hasConcept C2779013556 @default.
• W4307777483 hasConcept C502942594 @default.
• W4307777483 hasConcept C50382708 @default.
• W4307777483 hasConcept C55493867 @default.
• W4307777483 hasConcept C63363279 @default.
• W4307777483 hasConcept C71924100 @default.
• W4307777483 hasConcept C86803240 @default.
• W4307777483 hasConceptScore W4307777483C104317684 @default.
• W4307777483 hasConceptScore W4307777483C10515644 @default.
• W4307777483 hasConceptScore W4307777483C105580179 @default.
• W4307777483 hasConceptScore W4307777483C121608353 @default.
• W4307777483 hasConceptScore W4307777483C126322002 @default.
• W4307777483 hasConceptScore W4307777483C142724271 @default.
• W4307777483 hasConceptScore W4307777483C143998085 @default.
• W4307777483 hasConceptScore W4307777483C146357865 @default.
• W4307777483 hasConceptScore W4307777483C151730666 @default.
• W4307777483 hasConceptScore W4307777483C204232928 @default.
• W4307777483 hasConceptScore W4307777483C2779013556 @default.
• W4307777483 hasConceptScore W4307777483C502942594 @default.
• W4307777483 hasConceptScore W4307777483C50382708 @default.
• W4307777483 hasConceptScore W4307777483C55493867 @default.
• W4307777483 hasConceptScore W4307777483C63363279 @default.
• W4307777483 hasConceptScore W4307777483C71924100 @default.
• W4307777483 hasConceptScore W4307777483C86803240 @default.
• W4307777483 hasIssue "11" @default.
• W4307777483 hasLocation W43077774831 @default.
• W4307777483 hasLocation W43077774832 @default.
• W4307777483 hasLocation W43077774833 @default.
• W4307777483 hasOpenAccess W4307777483 @default.
• W4307777483 hasPrimaryLocation W43077774831 @default.
• W4307777483 hasRelatedWork W1499339123 @default.
• W4307777483 hasRelatedWork W2348266771 @default.

• next