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- W4307799318 abstract "Recent insight in the genomic landscape of newly diagnosed multiple myeloma (NDMM) and its precursor conditions, monoclonal gammopathy of uncertain significance (MGUS), and smoldering myeloma have allowed the identification of patients with precursor conditions with a high risk of progression. These cases with “progressor” MGUS/SMM have a higher average mutation burden, have higher rates of mutations in specific genes such as MAPK, DNA repair, MYC , DIS3 , and are enriched for specific mutational signatures when compared to non-progressors and are comparable to those found in NDMM. The highly preserved clonal heterogeneity seen upon progression of SMM, combined with the importance of these early variables, suggests that the identification of progressors based on these findings could complement and enhance the currently available clinical models based on tumor burden. Mechanisms leading to relapse/refractory multiple myeloma (RRMM) are of clinical interest given worse overall survival in this population. An Increased mutational burden is seen in patients with RRMM when compared to NDMM, however, there is evidence of branching evolution with many of these mutations being present at the subclonal level. Likewise, alterations in proteins associated with proteosome inhibitor and immunomodulatory drugs activity could partially explain clinical resistance to these agents. Evidence of chromosomal events leading to copy number changes is seen, with the presence of TP53 deletion, mutation, or a combination of both being present in many cases. Additional chromosomal events such as 1q gain and amplification may also interact and lead to resistance." @default.
- W4307799318 created "2022-11-05" @default.
- W4307799318 creator A5003087873 @default.
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- W4307799318 creator A5061867174 @default.
- W4307799318 creator A5077846750 @default.
- W4307799318 date "2022-10-27" @default.
- W4307799318 modified "2023-09-30" @default.
- W4307799318 title "Advances in the molecular characterization of multiple myeloma and mechanism of therapeutic resistance" @default.
- W4307799318 cites W1517274096 @default.
- W4307799318 cites W1600286956 @default.
- W4307799318 cites W1600462418 @default.
- W4307799318 cites W1661103064 @default.
- W4307799318 cites W1795880523 @default.
- W4307799318 cites W1801543025 @default.
- W4307799318 cites W1964346287 @default.
- W4307799318 cites W1972271863 @default.
- W4307799318 cites W1973999018 @default.
- W4307799318 cites W1977943803 @default.
- W4307799318 cites W1997952190 @default.
- W4307799318 cites W2002927100 @default.
- W4307799318 cites W2006680755 @default.
- W4307799318 cites W2009802594 @default.
- W4307799318 cites W2013296669 @default.
- W4307799318 cites W2015345028 @default.
- W4307799318 cites W2016274355 @default.
- W4307799318 cites W2020298011 @default.
- W4307799318 cites W2025656486 @default.
- W4307799318 cites W2029204292 @default.
- W4307799318 cites W2031157863 @default.
- W4307799318 cites W2037050131 @default.
- W4307799318 cites W2050702798 @default.
- W4307799318 cites W2052645281 @default.
- W4307799318 cites W2059581635 @default.
- W4307799318 cites W2066700805 @default.
- W4307799318 cites W2066713758 @default.
- W4307799318 cites W2072753134 @default.
- W4307799318 cites W2093310335 @default.
- W4307799318 cites W2096735689 @default.
- W4307799318 cites W2101035019 @default.
- W4307799318 cites W2109948920 @default.
- W4307799318 cites W2117005724 @default.
- W4307799318 cites W2118294470 @default.
- W4307799318 cites W2119462367 @default.
- W4307799318 cites W2119707919 @default.
- W4307799318 cites W2123895023 @default.
- W4307799318 cites W2132258376 @default.
- W4307799318 cites W2144531125 @default.
- W4307799318 cites W2144728882 @default.
- W4307799318 cites W2153147430 @default.
- W4307799318 cites W2155165473 @default.
- W4307799318 cites W2156381278 @default.
- W4307799318 cites W2165702044 @default.
- W4307799318 cites W2168663436 @default.
- W4307799318 cites W2168856932 @default.
- W4307799318 cites W2169846247 @default.
- W4307799318 cites W2172242534 @default.
- W4307799318 cites W2173818354 @default.
- W4307799318 cites W2175072810 @default.
- W4307799318 cites W2215425676 @default.
- W4307799318 cites W2229483068 @default.
- W4307799318 cites W2280262338 @default.
- W4307799318 cites W2287899290 @default.
- W4307799318 cites W2291176625 @default.
- W4307799318 cites W2316160054 @default.
- W4307799318 cites W2329186770 @default.
- W4307799318 cites W2342056297 @default.
- W4307799318 cites W2346831633 @default.
- W4307799318 cites W2439803058 @default.
- W4307799318 cites W2494443970 @default.
- W4307799318 cites W2494644907 @default.
- W4307799318 cites W2500198294 @default.
- W4307799318 cites W2504076934 @default.
- W4307799318 cites W2512106959 @default.
- W4307799318 cites W2525613924 @default.
- W4307799318 cites W2528329272 @default.
- W4307799318 cites W2562243521 @default.
- W4307799318 cites W2566193100 @default.
- W4307799318 cites W2580091136 @default.
- W4307799318 cites W2611004920 @default.
- W4307799318 cites W2611824455 @default.
- W4307799318 cites W2746367132 @default.
- W4307799318 cites W2761234508 @default.
- W4307799318 cites W2764340845 @default.
- W4307799318 cites W2767256995 @default.
- W4307799318 cites W2767658830 @default.
- W4307799318 cites W2772566228 @default.
- W4307799318 cites W2786171287 @default.
- W4307799318 cites W2789928137 @default.
- W4307799318 cites W2805293188 @default.
- W4307799318 cites W2883591936 @default.
- W4307799318 cites W2887632829 @default.
- W4307799318 cites W2890161608 @default.
- W4307799318 cites W2890977830 @default.
- W4307799318 cites W2891882983 @default.
- W4307799318 cites W2897811394 @default.