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- W4307804923 abstract "Human artificial chromosomes (HACs) have been developed as genetic vectors with the capacity to carry large transgenic constructs or entire gene loci. HACs represent either truncated native chromosomes or de novo synthesized genetic constructs. The important features of HACs are their ultra-high capacity and ability to self-maintain as independent genetic elements, without integrating into host chromosomes. In this review, we discuss the development and construction methods, structural and functional features, as well as the areas of application of the main HAC types. Also, we address one of the most technically challenging and time-consuming steps in this technology the transfer of HACs from donor to recipient cells." @default.
- W4307804923 created "2022-11-06" @default.
- W4307804923 creator A5007958108 @default.
- W4307804923 creator A5068635155 @default.
- W4307804923 creator A5071394538 @default.
- W4307804923 date "2022-10-29" @default.
- W4307804923 modified "2023-09-25" @default.
- W4307804923 title "Human Artificial Chromosomes and Their Transfer to Target Cells" @default.
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- W4307804923 doi "https://doi.org/10.32607/actanaturae.11670" @default.
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