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• W4307804955 abstract "Abstract Purpose KLHDC7B is a member of Kelch family, with a Kelch domain in the C-terminal half, which plays a role in various cellular events, such as cytoskeletal arrangement, protein degradation, gene expression. Despite increasing evidence supporting KLHDC7B's vital role in tumorigenesis, a systematic analysis of KLHDC7B in cancers is lacking. Therefore, we intended to investigate the prognostic value for KLHDC7B across 33 cancer types and explore its potential immunological function. Methods GEO and TCGA databases were used to explore the role of KLHDC7B in 33 cancers. TIMER2, GEPIA2 and Kaplan–Meier plotter were utilized to explore the KLHDC7B expression level and prognostic value in different cancers. The pan cancer genetic variation and DNA methylation of KLHDC7B were analyzed by cBioPortal and MEXPRESS.TIMER2 was employed to investigate the correlation between KLHDC7B expression and immune infiltration. The relationship of KLHDC7B expression with TMB (tumor mutational burden) and MSI (microsatellite instability) were evaluated using Spearman correlation analysis. Finally, by GO and KEGG enrichment analysis, the underlying mechanisms of KLHDC7B in tumor pathophysiology were further investigated. Results KLHDC7B expression level was related to pathological stage, MSI, TMB, and immune cell infiltration in most cancers. Additionally, survival analysis showed that the expression of KLHDC7B was connected with overall survival (OS) in 3 cancers and disease-free survival (DFS) in five cancers. Furthermore, the enrichment analysis revealed that the KLHDC7B collecting genes and binding proteins are related to the function of proteins and immune response of cells. Conclusion KLHDC7B demonstrate strong clinical utility as markers of prognostic and immune response in pan-cancer." @default.
• W4307804955 created "2022-11-06" @default.
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• W4307804955 date "2022-11-01" @default.
• W4307804955 modified "2023-09-29" @default.
• W4307804955 title "A Prognostic and Immunological Analysis of 7B-containing Kelch structural domain（KLHDC7B）in Pan- Cancer: A Potential Target for Immunotherapy and Survival" @default.
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• W4307804955 doi "https://doi.org/10.21203/rs.3.rs-2206228/v1" @default.
• W4307804955 hasPublicationYear "2022" @default.
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