FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307804965> ?p ?o ?g. }

• W4307804965 endingPage "A209" @default.
• W4307804965 startingPage "A209" @default.
• W4307804965 abstract "Abstract Introduction Parathyroid crisis is a serious, life-threatening complication of primary hyperparathyroidism (PHPT) which causes severe symptomatic hypercalcemia and affects multiple organ systems. PHPT is far less common in children and young adults, but they are frequently symptomatic often with kidney and skeletal involvement. We report a case of young adult who presents with severe symptomatic hypercalcemia with classical skeletal findings. Case A 23-year-old man with past medical history of autism spectrum disorder and obesity presented with extreme fatigue, malaise, epigastric pain, nausea and vomiting for 5 days. Patient also reported diffuse bilateral lower extremity pain for 1 year with weakness and difficulty in ambulation for 1 month. He did not see any provider in the last 2 years. He was not on any prescription or over the counter medications. He was found to have severe hypercalcemia with corrected calcium of 14.7 mg/dL, low phosphorus 1.6 mg/dL, low 25 hydroxy vitamin D &lt;4 ng/mL, very high parathyroid hormone (PTH) 1859 pg/mL and high alkaline phosphatase 1167 U/L. No prior history of hypercalcemia. No family history of hypercalcemia, thyroid cancer, pheochromocytoma, pituitary or pancreatic tumor. CT abdomen was performed on admission due to severe gastrointestinal symptoms which revealed left nephrolithiasis, sclerotic changes in the end plates of the spines and multiple lucent lesions throughout femoral necks, symphysis pubis, and sacroiliac joints. It also showed chronic rib fractures. Knee x ray showed bilateral extensive sub-periosteal, sub-tendinous and subligamentous bony resorption and brown tumors. Patient was treated with aggressive intravenous (IV) hydration, calcitonin and IV pamidronate with gradual improvement in serum calcium. Thyroid ultrasound showed left inferior 3.2 cm mass suspicious for parathyroid adenoma. Surgical team was consulted. Patient underwent left inferior parathyroidectomy along with left hemithyroidectomy due to concern for parathyroid cancer. Surgical pathology showed parathyroid adenoma. Patient required aggressive calcium supplementation, along with vitamin D, calcitriol and magnesium to prevent severe hypocalcemia and hungry bone syndrome. He recovered well and was discharged with outpatient follow up. Conclusion Our case highlights that parathyroid crisis is a serious endocrine emergency associated with significant morbidity and urgent surgical intervention after stabilizing serum calcium level leads to a favorable outcome. The finding of parathyroid adenoma is interesting because the constellation of severe skeletal involvement, nephrolithiasis and significantly elevated PTH and calcium in our patient was concerning for parathyroid carcinoma. Clinicians should consider both in patients with severe hypercalcemia and PTH more than 5 times upper limit of normal. The characteristic finding of osteitis fibrosa cystica in our case is rare in United States and is seen in &lt;2% of patients with PHPT due to routine biochemical screening leading to early diagnosis of asymptomatic cases. Presentation: Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m." @default.
• W4307804965 created "2022-11-06" @default.
• W4307804965 creator A5075962099 @default.
• W4307804965 creator A5085968117 @default.
• W4307804965 date "2022-11-01" @default.
• W4307804965 modified "2023-10-18" @default.
• W4307804965 title "PSAT200 Parathyroid Crisis Presenting as Failure to Thrive in a Young Man" @default.
• W4307804965 doi "https://doi.org/10.1210/jendso/bvac150.430" @default.
• W4307804965 hasPublicationYear "2022" @default.
• W4307804965 type Work @default.
• W4307804965 citedByCount "0" @default.
• W4307804965 crossrefType "journal-article" @default.
• W4307804965 hasAuthorship W4307804965A5075962099 @default.
• W4307804965 hasAuthorship W4307804965A5085968117 @default.
• W4307804965 hasBestOaLocation W43078049651 @default.
• W4307804965 hasConcept C126322002 @default.
• W4307804965 hasConcept C141071460 @default.
• W4307804965 hasConcept C2775945674 @default.
• W4307804965 hasConcept C2776917539 @default.
• W4307804965 hasConcept C2778242168 @default.
• W4307804965 hasConcept C2780505380 @default.
• W4307804965 hasConcept C2780580376 @default.
• W4307804965 hasConcept C2780852908 @default.
• W4307804965 hasConcept C2780955771 @default.
• W4307804965 hasConcept C2781208988 @default.
• W4307804965 hasConcept C519063684 @default.
• W4307804965 hasConcept C71924100 @default.
• W4307804965 hasConceptScore W4307804965C126322002 @default.
• W4307804965 hasConceptScore W4307804965C141071460 @default.
• W4307804965 hasConceptScore W4307804965C2775945674 @default.
• W4307804965 hasConceptScore W4307804965C2776917539 @default.
• W4307804965 hasConceptScore W4307804965C2778242168 @default.
• W4307804965 hasConceptScore W4307804965C2780505380 @default.
• W4307804965 hasConceptScore W4307804965C2780580376 @default.
• W4307804965 hasConceptScore W4307804965C2780852908 @default.
• W4307804965 hasConceptScore W4307804965C2780955771 @default.
• W4307804965 hasConceptScore W4307804965C2781208988 @default.
• W4307804965 hasConceptScore W4307804965C519063684 @default.
• W4307804965 hasConceptScore W4307804965C71924100 @default.
• W4307804965 hasIssue "Supplement_1" @default.
• W4307804965 hasLocation W43078049651 @default.
• W4307804965 hasLocation W43078049652 @default.
• W4307804965 hasOpenAccess W4307804965 @default.
• W4307804965 hasPrimaryLocation W43078049651 @default.
• W4307804965 hasRelatedWork W1906153752 @default.
• W4307804965 hasRelatedWork W2013157223 @default.
• W4307804965 hasRelatedWork W2089045902 @default.
• W4307804965 hasRelatedWork W2162258982 @default.
• W4307804965 hasRelatedWork W2471203366 @default.
• W4307804965 hasRelatedWork W2942959370 @default.
• W4307804965 hasRelatedWork W3036606923 @default.
• W4307804965 hasRelatedWork W4283749754 @default.
• W4307804965 hasRelatedWork W4284884524 @default.
• W4307804965 hasRelatedWork W4303021231 @default.
• W4307804965 hasVolume "6" @default.
• W4307804965 isParatext "false" @default.
• W4307804965 isRetracted "false" @default.
• W4307804965 workType "article" @default.