Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307813738> ?p ?o ?g. }
- W4307813738 endingPage "64" @default.
- W4307813738 startingPage "59" @default.
- W4307813738 abstract "The low cerebral metabolic rate of oxygen despite the relatively preserved perfusion in Alzheimer’s disease (AD) patients’ medial temporal lobes suggest histotoxic hypoxia due to mitochondrial dysfunction that is independent of, but could precede, insulin resistance. Neuropathological, metabolomic, and preclinical evidence are consistent with the notion that this mitochondrial dysfunction may be contributed to by oxidative stress and DNA damage, leading to poly-(ADP-ribose)-polymerase-1 (PARP1) activation and consequent AMP accumulation, clogging of mitochondrial adenine nucleotide transporters (ANTs), matrix ADP deprivation, and ATP synthase inhibition. Complementary mechanisms may include mitochondrial-protein poly-ADP-ribosylation and mitochondrial-biogenesis suppression via PARPs outcompeting Sirtuin-1 (SIRT1) for nicotinamide-adenine-dinucleotide (NAD+)." @default.
- W4307813738 created "2022-11-06" @default.
- W4307813738 creator A5003173576 @default.
- W4307813738 creator A5042724248 @default.
- W4307813738 creator A5053565319 @default.
- W4307813738 creator A5058435139 @default.
- W4307813738 creator A5070223499 @default.
- W4307813738 creator A5072535779 @default.
- W4307813738 creator A5080660409 @default.
- W4307813738 date "2022-11-01" @default.
- W4307813738 modified "2023-10-18" @default.
- W4307813738 title "Does oxidative DNA damage trigger histotoxic hypoxia via PARP1/AMP-driven mitochondrial ADP depletion-induced ATP synthase inhibition in Alzheimer’s disease?" @default.
- W4307813738 cites W1542215809 @default.
- W4307813738 cites W1543788907 @default.
- W4307813738 cites W1583094119 @default.
- W4307813738 cites W1867176171 @default.
- W4307813738 cites W1965406612 @default.
- W4307813738 cites W1969344217 @default.
- W4307813738 cites W1980421520 @default.
- W4307813738 cites W1982795519 @default.
- W4307813738 cites W1996776195 @default.
- W4307813738 cites W1998742630 @default.
- W4307813738 cites W2001665323 @default.
- W4307813738 cites W2002017682 @default.
- W4307813738 cites W2002540006 @default.
- W4307813738 cites W2003748141 @default.
- W4307813738 cites W2006111626 @default.
- W4307813738 cites W2018961056 @default.
- W4307813738 cites W2020304127 @default.
- W4307813738 cites W2022622191 @default.
- W4307813738 cites W2029581820 @default.
- W4307813738 cites W2030079903 @default.
- W4307813738 cites W2030839561 @default.
- W4307813738 cites W2040432708 @default.
- W4307813738 cites W2041402562 @default.
- W4307813738 cites W2044749569 @default.
- W4307813738 cites W2052742260 @default.
- W4307813738 cites W2056044698 @default.
- W4307813738 cites W2056648984 @default.
- W4307813738 cites W2057622179 @default.
- W4307813738 cites W2060348944 @default.
- W4307813738 cites W2064954234 @default.
- W4307813738 cites W2065828987 @default.
- W4307813738 cites W2069815021 @default.
- W4307813738 cites W2074161856 @default.
- W4307813738 cites W2078944454 @default.
- W4307813738 cites W2080599381 @default.
- W4307813738 cites W2101966650 @default.
- W4307813738 cites W2104346169 @default.
- W4307813738 cites W2104552307 @default.
- W4307813738 cites W2108926627 @default.
- W4307813738 cites W2122059704 @default.
- W4307813738 cites W2122545253 @default.
- W4307813738 cites W2134547791 @default.
- W4307813738 cites W2146142796 @default.
- W4307813738 cites W2151347791 @default.
- W4307813738 cites W2151861142 @default.
- W4307813738 cites W2153284686 @default.
- W4307813738 cites W2165427528 @default.
- W4307813738 cites W2167253239 @default.
- W4307813738 cites W2252783105 @default.
- W4307813738 cites W2292736632 @default.
- W4307813738 cites W2295054364 @default.
- W4307813738 cites W2296388187 @default.
- W4307813738 cites W2300199666 @default.
- W4307813738 cites W2337885453 @default.
- W4307813738 cites W2516989289 @default.
- W4307813738 cites W2556604021 @default.
- W4307813738 cites W2761494190 @default.
- W4307813738 cites W2771043670 @default.
- W4307813738 cites W2783896167 @default.
- W4307813738 cites W2786835074 @default.
- W4307813738 cites W2788378708 @default.
- W4307813738 cites W2793911225 @default.
- W4307813738 cites W2794725954 @default.
- W4307813738 cites W2889300844 @default.
- W4307813738 cites W2892170438 @default.
- W4307813738 cites W2908658437 @default.
- W4307813738 cites W2976197289 @default.
- W4307813738 cites W2980172305 @default.
- W4307813738 cites W2999300346 @default.
- W4307813738 cites W3011303090 @default.
- W4307813738 cites W3013065605 @default.
- W4307813738 cites W3014299552 @default.
- W4307813738 cites W3018719581 @default.
- W4307813738 cites W3035782677 @default.
- W4307813738 cites W3036185152 @default.
- W4307813738 cites W3124892237 @default.
- W4307813738 cites W3129429271 @default.
- W4307813738 cites W3134087839 @default.
- W4307813738 cites W3149142423 @default.
- W4307813738 cites W3153032775 @default.
- W4307813738 cites W3183580556 @default.
- W4307813738 cites W4210702584 @default.
- W4307813738 cites W4282930869 @default.
- W4307813738 doi "https://doi.org/10.1016/j.mito.2022.10.005" @default.
- W4307813738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36367519" @default.
- W4307813738 hasPublicationYear "2022" @default.