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- W4307816209 endingPage "113502" @default.
- W4307816209 startingPage "113502" @default.
- W4307816209 abstract "In vitro cell systems can support hazard characterization and identify mechanisms involved in toxicity; however, using in vitro data for risk assessment still is challenging. As part of an effort to develop approaches for a complex operating site used for biocide packaging and distribution, we evaluated in vitro assays that could be used in a site management format. Across 66 studies, 108 pesticides were assessed on ten human-derived cell types at four endpoints. In vitro IC50s were compared to in vivo guidelines, NOEL/NOAELs, and ADIs using Spearman correlation and linear regression models. While human neuroblastoma cells (SH-SY5Y) were the most sensitive, HepG2 was the most used cell line in evaluating the toxicity of pesticides. Amongst the ten human cell lines, the IC50s derived from SH-SY5Y cells, using MTT-24 & 48 h (the most used assay) correlated (rho = 0.56–0.79; p < 0.05) with ADIs and NOEL/NOAELs. Although in vitro cell systems have some limitations, the correlation between in vitro data derived from SH-SY5Y cells and in vivo safety guidelines can provide site investigators with a tool to survey and prioritize areas and media of concern at complex operating sites impacted by pesticide mixtures." @default.
- W4307816209 created "2022-11-06" @default.
- W4307816209 creator A5012279719 @default.
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- W4307816209 creator A5087052555 @default.
- W4307816209 creator A5089869954 @default.
- W4307816209 date "2022-12-01" @default.
- W4307816209 modified "2023-09-30" @default.
- W4307816209 title "Correlation between in vitro toxicity of pesticides and in vivo risk guidelines in support of complex operating site risk management: A meta-analysis" @default.
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- W4307816209 doi "https://doi.org/10.1016/j.fct.2022.113502" @default.