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- W4307821284 abstract "Bacteria constitute a major lifeform on this planet and play numerous roles in ecology, physiology, and human disease. However, conventional methods to probe their activities are limited in their ability to visualize and identify their functions in these diverse settings. In the last two decades, the application of click chemistry to label these microbes has deepened our understanding of bacterial physiology. With the development of a plethora of chemical tools that target many biological molecules, it is possible to track these microorganisms in real-time and at unprecedented resolution. Here, we review click chemistry, including bioorthogonal reactions, and their applications in imaging bacterial glycans, lipids, proteins, and nucleic acids using chemical reporters. We also highlight significant advances that have enabled biological discoveries that have heretofore remained elusive." @default.
- W4307821284 created "2022-11-06" @default.
- W4307821284 creator A5067519428 @default.
- W4307821284 creator A5091913198 @default.
- W4307821284 date "2022-10-28" @default.
- W4307821284 modified "2023-10-18" @default.
- W4307821284 title "Shedding Light on Bacterial Physiology with Click Chemistry" @default.
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