Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307859903> ?p ?o ?g. }
- W4307859903 abstract "Kidney disease is a complex disease with several different etiologies and underlying associated pathophysiology. This is reflected by the lack of effective treatment therapies in chronic kidney disease (CKD) that stop disease progression. However, novel strategies, recent scientific breakthroughs, and technological advances have revealed new possibilities for finding novel disease drivers in CKD. This review describes some of the latest advances in the field and brings them together in a more holistic framework as applied to identification and validation of disease drivers in CKD. It uses high-resolution ‘patient-centric’ omics data sets, advanced in silico tools (systems biology, connectivity mapping, and machine learning) and ‘state-of-the-art‘ experimental systems (complex 3D systems in vitro , CRISPR gene editing, and various model biological systems in vivo ). Application of such a framework is expected to increase the likelihood of successful identification of novel drug candidates based on strong human target validation and a better scientific understanding of underlying mechanisms." @default.
- W4307859903 created "2022-11-06" @default.
- W4307859903 creator A5005032766 @default.
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- W4307859903 creator A5088121999 @default.
- W4307859903 date "2022-11-02" @default.
- W4307859903 modified "2023-09-26" @default.
- W4307859903 title "Selecting the right therapeutic target for kidney disease" @default.
- W4307859903 cites W1667692994 @default.
- W4307859903 cites W1822077738 @default.
- W4307859903 cites W1965675690 @default.
- W4307859903 cites W1966474292 @default.
- W4307859903 cites W1967105697 @default.
- W4307859903 cites W1970024336 @default.
- W4307859903 cites W1977179045 @default.
- W4307859903 cites W1980503007 @default.
- W4307859903 cites W1984412592 @default.
- W4307859903 cites W1985461110 @default.
- W4307859903 cites W1988442935 @default.
- W4307859903 cites W1989277988 @default.
- W4307859903 cites W1997999028 @default.
- W4307859903 cites W2011033546 @default.
- W4307859903 cites W2023098599 @default.
- W4307859903 cites W2040847667 @default.
- W4307859903 cites W2050540128 @default.
- W4307859903 cites W2057388700 @default.
- W4307859903 cites W2089230882 @default.
- W4307859903 cites W2090247362 @default.
- W4307859903 cites W2091076764 @default.
- W4307859903 cites W2098151682 @default.
- W4307859903 cites W2111410841 @default.
- W4307859903 cites W2114008865 @default.
- W4307859903 cites W2131445242 @default.
- W4307859903 cites W2136540712 @default.
- W4307859903 cites W2143282831 @default.
- W4307859903 cites W2147797461 @default.
- W4307859903 cites W2148652246 @default.
- W4307859903 cites W2159721858 @default.
- W4307859903 cites W2162159731 @default.
- W4307859903 cites W2176166968 @default.
- W4307859903 cites W2280149979 @default.
- W4307859903 cites W2319034424 @default.
- W4307859903 cites W2400270437 @default.
- W4307859903 cites W2463195069 @default.
- W4307859903 cites W2465520285 @default.
- W4307859903 cites W2507254725 @default.
- W4307859903 cites W2512088910 @default.
- W4307859903 cites W2512229672 @default.
- W4307859903 cites W2519075653 @default.
- W4307859903 cites W2530360197 @default.
- W4307859903 cites W2558454696 @default.
- W4307859903 cites W2558838260 @default.
- W4307859903 cites W2566577917 @default.
- W4307859903 cites W2587367660 @default.
- W4307859903 cites W2606445721 @default.
- W4307859903 cites W2607340069 @default.
- W4307859903 cites W2612015400 @default.
- W4307859903 cites W2750371837 @default.
- W4307859903 cites W2761974242 @default.
- W4307859903 cites W2772891196 @default.
- W4307859903 cites W2787626080 @default.
- W4307859903 cites W2787894218 @default.
- W4307859903 cites W2792578296 @default.
- W4307859903 cites W2792874817 @default.
- W4307859903 cites W2796019185 @default.
- W4307859903 cites W2802030535 @default.
- W4307859903 cites W2803371370 @default.
- W4307859903 cites W2803499747 @default.
- W4307859903 cites W2803685415 @default.
- W4307859903 cites W2810367637 @default.
- W4307859903 cites W2887161891 @default.
- W4307859903 cites W2895486342 @default.
- W4307859903 cites W2897146184 @default.
- W4307859903 cites W2898881712 @default.
- W4307859903 cites W2899433742 @default.
- W4307859903 cites W2901335962 @default.
- W4307859903 cites W2901597112 @default.
- W4307859903 cites W2902585499 @default.
- W4307859903 cites W2903061871 @default.
- W4307859903 cites W2906423313 @default.
- W4307859903 cites W2910111050 @default.
- W4307859903 cites W2910124901 @default.
- W4307859903 cites W2912021608 @default.
- W4307859903 cites W2913348902 @default.
- W4307859903 cites W2919089713 @default.
- W4307859903 cites W2922291289 @default.
- W4307859903 cites W2946497163 @default.