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- W4307864166 abstract "The MHC- self immunopeptidome of professional antigen presenting cells is a cognate ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T cells. In regulatory T cells, the TCR signaling associated with MHC-peptide recognition induces antigen specific as well as bystander immunosuppression. On the other hand, TCR activation of conventional T cells is associated with protective immunity. As such the peripheral T cell repertoire is populated by a number of T cells with different phenotypes and different TCRs, which can recognize the same MHC-self-peptide complex, resulting in opposite immunological outcomes. This article summarizes what is known about regulatory and conventional T cell recognition of the MHC-self-immunopeptidome at steady state and in inflammatory conditions associated with increased T and B cell self-reactivity, discussing how changes in the MHC-ligandome including epitope copy number and post-translational modifications can tilt the balance toward the expansion of pro-inflammatory or regulatory T cells." @default.
- W4307864166 created "2022-11-06" @default.
- W4307864166 creator A5037605110 @default.
- W4307864166 creator A5061652691 @default.
- W4307864166 date "2022-11-02" @default.
- W4307864166 modified "2023-10-14" @default.
- W4307864166 title "The yin/yang balance of the MHC-self-immunopeptidome" @default.
- W4307864166 cites W1568356880 @default.
- W4307864166 cites W1573103899 @default.
- W4307864166 cites W1596927028 @default.
- W4307864166 cites W1618818749 @default.
- W4307864166 cites W1637703629 @default.
- W4307864166 cites W1667352440 @default.
- W4307864166 cites W1780101594 @default.
- W4307864166 cites W1782545213 @default.
- W4307864166 cites W1787048953 @default.
- W4307864166 cites W1892577665 @default.
- W4307864166 cites W1963599151 @default.
- W4307864166 cites W1964964271 @default.
- W4307864166 cites W1978073168 @default.
- W4307864166 cites W1982180094 @default.
- W4307864166 cites W1985996096 @default.
- W4307864166 cites W1995434364 @default.
- W4307864166 cites W2000363887 @default.
- W4307864166 cites W2010973471 @default.
- W4307864166 cites W2011395619 @default.
- W4307864166 cites W2012542401 @default.
- W4307864166 cites W2012628829 @default.
- W4307864166 cites W2013467526 @default.
- W4307864166 cites W2016191219 @default.
- W4307864166 cites W2018192258 @default.
- W4307864166 cites W2024505041 @default.
- W4307864166 cites W2025345728 @default.
- W4307864166 cites W2028183411 @default.
- W4307864166 cites W2031269139 @default.
- W4307864166 cites W2033262429 @default.
- W4307864166 cites W2046708031 @default.
- W4307864166 cites W2050515006 @default.
- W4307864166 cites W2060264122 @default.
- W4307864166 cites W2061120297 @default.
- W4307864166 cites W2061938847 @default.
- W4307864166 cites W2064365779 @default.
- W4307864166 cites W2067030201 @default.
- W4307864166 cites W2067865546 @default.
- W4307864166 cites W2068145675 @default.
- W4307864166 cites W2072830090 @default.
- W4307864166 cites W2076198413 @default.
- W4307864166 cites W2077253963 @default.
- W4307864166 cites W2086405243 @default.
- W4307864166 cites W2086581449 @default.
- W4307864166 cites W2103600875 @default.
- W4307864166 cites W2109033058 @default.
- W4307864166 cites W2116019929 @default.
- W4307864166 cites W2116478762 @default.
- W4307864166 cites W2123507662 @default.
- W4307864166 cites W2131926827 @default.
- W4307864166 cites W2133484547 @default.
- W4307864166 cites W2136364425 @default.
- W4307864166 cites W2141649011 @default.
- W4307864166 cites W2143031309 @default.
- W4307864166 cites W2146957741 @default.
- W4307864166 cites W2153389047 @default.
- W4307864166 cites W2157040330 @default.
- W4307864166 cites W2160141171 @default.
- W4307864166 cites W2160954639 @default.
- W4307864166 cites W2161859936 @default.
- W4307864166 cites W2164285209 @default.
- W4307864166 cites W2164793815 @default.
- W4307864166 cites W2164890649 @default.
- W4307864166 cites W2205207837 @default.
- W4307864166 cites W2283987297 @default.
- W4307864166 cites W2286170889 @default.
- W4307864166 cites W2332517313 @default.
- W4307864166 cites W2337433508 @default.
- W4307864166 cites W2339405566 @default.
- W4307864166 cites W2405227830 @default.
- W4307864166 cites W2467439984 @default.
- W4307864166 cites W2513620066 @default.
- W4307864166 cites W2538855466 @default.
- W4307864166 cites W2592135754 @default.
- W4307864166 cites W2594773162 @default.
- W4307864166 cites W2743949118 @default.
- W4307864166 cites W2766941573 @default.
- W4307864166 cites W2774538582 @default.
- W4307864166 cites W2793411374 @default.
- W4307864166 cites W2901872876 @default.
- W4307864166 cites W2909310282 @default.
- W4307864166 cites W2938726064 @default.
- W4307864166 cites W2945353468 @default.
- W4307864166 cites W2951410274 @default.
- W4307864166 cites W2966549733 @default.
- W4307864166 cites W2970539626 @default.
- W4307864166 cites W2981958543 @default.
- W4307864166 cites W2992358785 @default.
- W4307864166 cites W3029209635 @default.
- W4307864166 cites W3043391156 @default.
- W4307864166 cites W3046023696 @default.
- W4307864166 cites W3093298670 @default.
- W4307864166 cites W3095574503 @default.
- W4307864166 cites W3128190649 @default.