FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307871681> ?p ?o ?g. }

• W4307871681 abstract "Objective Major bleeding is associated with poor hospital prognosis in patients with acute coronary syndrome (ACS). Despite its clinical importance, there are limited studies on the incidence and risk factors for major bleeding in ACS patients with dual anti-platelet therapy (DAPT) without access to revascularization. Methods We analyzed data from 19,186 patients on DAPT after ACS with no access to revascularization from Clinical Pathway for Acute Coronary Syndrome in China Phase 3 (CPACS-3) cohort, which was conducted from 2011 to 2014. Major bleeding included intracranial hemorrhage, clinically significant bleeding, or bleeding requiring blood transfusion. Factors associated with in-hospital major bleeding were assessed using Poisson regressions with generalized estimating equations to account for the clustering effect. Results A total of 75 (0.39%) patients experienced major bleeding during hospitalization. Among subtypes of ACS, 0.65% of patients with STEMI, 0.33% with NSTEMI, and 0.13% with unstable angina had in-hospital major bleeding ( p &lt; 0.001). The patients who experienced major bleeding had a longer length of stay (median 12 vs. 9 days, p = 0.011) and a higher all-cause in-hospital death rate (22.7 vs. 3.7%, p &lt; 0.001). Multivariable analysis showed advancing age (RR = 1.52 for every 10 years increase, 95% CI: 1.13, 2.05), impaired renal function (RR = 1.79, 95% CI: 1.10, 2.92), use of fibrinolytic drugs (RR = 2.93, 95% CI: 1.55, 5.56), and severe diseases other than cardiovascular and renal diseases (RR = 5.56, 95% CI: 1.10, 28.07) were associated with increased risk of major bleeding, whereas using renin–angiotensin system inhibitors (RR = 0.54, 95% CI: 0.36, 0.81) was associated with decreased risk of major bleeding. These independent factors together showed good predictive accuracy with an AUC of 0.788 (95% CI: 0.734, 0.841). Conclusion Among ACS patients on DAPT, advancing age, impaired renal function, thrombolytic treatment, and severe comorbidities were independently associated with a higher risk of in-hospital major bleeding." @default.
• W4307871681 created "2022-11-06" @default.
• W4307871681 creator A5037456730 @default.
• W4307871681 creator A5045349004 @default.
• W4307871681 creator A5048745742 @default.
• W4307871681 creator A5056053058 @default.
• W4307871681 creator A5066820530 @default.
• W4307871681 creator A5081844561 @default.
• W4307871681 date "2022-10-31" @default.
• W4307871681 modified "2023-09-30" @default.
• W4307871681 title "In-hospital major bleeding in patients with acute coronary syndrome medically treated with dual anti-platelet therapy: Associated factors and impact on mortality" @default.
• W4307871681 cites W1551289483 @default.
• W4307871681 cites W1553345686 @default.
• W4307871681 cites W1573872903 @default.
• W4307871681 cites W1947176863 @default.
• W4307871681 cites W1967520661 @default.
• W4307871681 cites W2023633741 @default.
• W4307871681 cites W2069213110 @default.
• W4307871681 cites W2069255298 @default.
• W4307871681 cites W2084276985 @default.
• W4307871681 cites W2109577952 @default.
• W4307871681 cites W2131181128 @default.
• W4307871681 cites W2140501627 @default.
• W4307871681 cites W2149011208 @default.
• W4307871681 cites W2274281903 @default.
• W4307871681 cites W2324839838 @default.
• W4307871681 cites W2342318753 @default.
• W4307871681 cites W2377440380 @default.
• W4307871681 cites W2465688751 @default.
• W4307871681 cites W2497397127 @default.
• W4307871681 cites W2562988562 @default.
• W4307871681 cites W2593571361 @default.
• W4307871681 cites W2604910616 @default.
• W4307871681 cites W2786978571 @default.
• W4307871681 cites W2915400351 @default.
• W4307871681 cites W2936221017 @default.
• W4307871681 cites W2937846629 @default.
• W4307871681 cites W2946796958 @default.
• W4307871681 cites W2973068166 @default.
• W4307871681 cites W2988608794 @default.
• W4307871681 cites W3009001751 @default.
• W4307871681 cites W3013043430 @default.
• W4307871681 cites W3027509262 @default.
• W4307871681 cites W3120960382 @default.
• W4307871681 cites W3156142627 @default.
• W4307871681 cites W3162195278 @default.
• W4307871681 cites W3193614870 @default.
• W4307871681 cites W3212304720 @default.
• W4307871681 doi "https://doi.org/10.3389/fcvm.2022.878270" @default.
• W4307871681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36386364" @default.
• W4307871681 hasPublicationYear "2022" @default.
• W4307871681 type Work @default.
• W4307871681 citedByCount "1" @default.
• W4307871681 countsByYear W43078716812023 @default.
• W4307871681 crossrefType "journal-article" @default.
• W4307871681 hasAuthorship W4307871681A5037456730 @default.
• W4307871681 hasAuthorship W4307871681A5045349004 @default.
• W4307871681 hasAuthorship W4307871681A5048745742 @default.
• W4307871681 hasAuthorship W4307871681A5056053058 @default.
• W4307871681 hasAuthorship W4307871681A5066820530 @default.
• W4307871681 hasAuthorship W4307871681A5081844561 @default.
• W4307871681 hasBestOaLocation W43078716811 @default.
• W4307871681 hasConcept C120665830 @default.
• W4307871681 hasConcept C121332964 @default.
• W4307871681 hasConcept C126322002 @default.
• W4307871681 hasConcept C141071460 @default.
• W4307871681 hasConcept C164705383 @default.
• W4307871681 hasConcept C2777698277 @default.
• W4307871681 hasConcept C2777785093 @default.
• W4307871681 hasConcept C2777849778 @default.
• W4307871681 hasConcept C2779464278 @default.
• W4307871681 hasConcept C2908647359 @default.
• W4307871681 hasConcept C500558357 @default.
• W4307871681 hasConcept C61511704 @default.
• W4307871681 hasConcept C71924100 @default.
• W4307871681 hasConcept C73269764 @default.
• W4307871681 hasConcept C99454951 @default.
• W4307871681 hasConceptScore W4307871681C120665830 @default.
• W4307871681 hasConceptScore W4307871681C121332964 @default.
• W4307871681 hasConceptScore W4307871681C126322002 @default.
• W4307871681 hasConceptScore W4307871681C141071460 @default.
• W4307871681 hasConceptScore W4307871681C164705383 @default.
• W4307871681 hasConceptScore W4307871681C2777698277 @default.
• W4307871681 hasConceptScore W4307871681C2777785093 @default.
• W4307871681 hasConceptScore W4307871681C2777849778 @default.
• W4307871681 hasConceptScore W4307871681C2779464278 @default.
• W4307871681 hasConceptScore W4307871681C2908647359 @default.
• W4307871681 hasConceptScore W4307871681C500558357 @default.
• W4307871681 hasConceptScore W4307871681C61511704 @default.
• W4307871681 hasConceptScore W4307871681C71924100 @default.
• W4307871681 hasConceptScore W4307871681C73269764 @default.
• W4307871681 hasConceptScore W4307871681C99454951 @default.
• W4307871681 hasLocation W43078716811 @default.
• W4307871681 hasLocation W43078716812 @default.
• W4307871681 hasLocation W43078716813 @default.
• W4307871681 hasLocation W43078716814 @default.
• W4307871681 hasOpenAccess W4307871681 @default.
• W4307871681 hasPrimaryLocation W43078716811 @default.
• W4307871681 hasRelatedWork W2037817991 @default.
• W4307871681 hasRelatedWork W2092431849 @default.

• next