FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307888115> ?p ?o ?g. }

• W4307888115 endingPage "e071281" @default.
• W4307888115 startingPage "e071281" @default.
• W4307888115 abstract "Abstract Objectives To determine whether patient reported outcomes improve after single stage versus two stage revision surgery for prosthetic joint infection of the hip, and to determine the cost effectiveness of these procedures. Design Pragmatic, parallel group, open label, randomised controlled trial. Setting High volume tertiary referral centres or orthopaedic units in the UK (n=12) and in Sweden (n=3), recruiting from 1 March 2015 to 19 December 2018. Participants 140 adults (aged ≥18 years) with a prosthetic joint infection of the hip who required revision (65 randomly assigned to single stage and 75 to two stage revision). Interventions A computer generated 1:1 randomisation list stratified by hospital was used to allocate participants with prosthetic joint infection of the hip to a single stage or a two stage revision procedure. Main outcome measures The primary intention-to-treat outcome was pain, stiffness, and functional limitations 18 months after randomisation, measured by the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) score. Secondary outcomes included surgical complications and joint infection. The economic evaluation (only assessed in UK participants) compared quality adjusted life years and costs between the randomised groups. Results The mean age of participants was 71 years (standard deviation 9) and 51 (36%) were women. WOMAC scores did not differ between groups at 18 months (mean difference 0.13 (95% confidence interval −8.20 to 8.46), P=0.98); however, the single stage procedure was better at three months (11.53 (3.89 to 19.17), P=0.003), but not from six months onwards. Intraoperative events occurred in five (8%) participants in the single stage group and 20 (27%) in the two stage group (P=0.01). At 18 months, nine (14%) participants in the single stage group and eight (11%) in the two stage group had at least one marker of possible ongoing infection (P=0.62). From the perspective of healthcare providers and personal social services, single stage revision was cost effective with an incremental net monetary benefit of £11 167 (95% confidence interval £638 to £21 696) at a £20 000 per quality adjusted life years threshold (£1.0; $1.1; €1.4). Conclusions At 18 months, single stage revision compared with two stage revision for prosthetic joint infection of the hip showed no superiority by patient reported outcome. Single stage revision had a better outcome at three months, fewer intraoperative complications, and was cost effective. Patients prefer early restoration of function, therefore, when deciding treatment, surgeons should consider patient preferences and the cost effectiveness of single stage surgery. Trial registration ISRCTN registry ISRCTN10956306 ." @default.
• W4307888115 created "2022-11-06" @default.
• W4307888115 creator A5005908129 @default.
• W4307888115 creator A5011554236 @default.
• W4307888115 creator A5013764429 @default.
• W4307888115 creator A5027248898 @default.
• W4307888115 creator A5044372933 @default.
• W4307888115 creator A5056759579 @default.
• W4307888115 creator A5060427520 @default.
• W4307888115 creator A5069596093 @default.
• W4307888115 creator A5070151669 @default.
• W4307888115 creator A5071306973 @default.
• W4307888115 creator A5072210649 @default.
• W4307888115 creator A5079198169 @default.
• W4307888115 creator A5079902505 @default.
• W4307888115 creator A5085526983 @default.
• W4307888115 creator A5085793081 @default.
• W4307888115 creator A5088259081 @default.
• W4307888115 creator A5088672135 @default.
• W4307888115 creator A5089233487 @default.
• W4307888115 date "2022-10-31" @default.
• W4307888115 modified "2023-10-03" @default.
• W4307888115 title "Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial" @default.
• W4307888115 cites W1770956638 @default.
• W4307888115 cites W1845447069 @default.
• W4307888115 cites W1909802012 @default.
• W4307888115 cites W1965216355 @default.
• W4307888115 cites W1983255179 @default.
• W4307888115 cites W1990166011 @default.
• W4307888115 cites W1996368662 @default.
• W4307888115 cites W2004446518 @default.
• W4307888115 cites W2017493893 @default.
• W4307888115 cites W2023394860 @default.
• W4307888115 cites W2050607185 @default.
• W4307888115 cites W2052066358 @default.
• W4307888115 cites W2079575346 @default.
• W4307888115 cites W2084858262 @default.
• W4307888115 cites W2085638389 @default.
• W4307888115 cites W2106091596 @default.
• W4307888115 cites W2106648617 @default.
• W4307888115 cites W2114747147 @default.
• W4307888115 cites W2147673462 @default.
• W4307888115 cites W2152763689 @default.
• W4307888115 cites W2158391623 @default.
• W4307888115 cites W2166281097 @default.
• W4307888115 cites W2186108349 @default.
• W4307888115 cites W2191186334 @default.
• W4307888115 cites W2257410119 @default.
• W4307888115 cites W2257988318 @default.
• W4307888115 cites W2268837081 @default.
• W4307888115 cites W2274722622 @default.
• W4307888115 cites W2276391253 @default.
• W4307888115 cites W2291468036 @default.
• W4307888115 cites W2324240896 @default.
• W4307888115 cites W2530223967 @default.
• W4307888115 cites W2562480455 @default.
• W4307888115 cites W2605242113 @default.
• W4307888115 cites W2605245624 @default.
• W4307888115 cites W2651959407 @default.
• W4307888115 cites W2792223958 @default.
• W4307888115 cites W2796384333 @default.
• W4307888115 cites W2912366334 @default.
• W4307888115 cites W3002764789 @default.
• W4307888115 cites W3045260928 @default.
• W4307888115 cites W3046799935 @default.
• W4307888115 cites W3108115343 @default.
• W4307888115 cites W3117846384 @default.
• W4307888115 cites W3203531937 @default.
• W4307888115 cites W4210336301 @default.
• W4307888115 cites W4256311010 @default.
• W4307888115 doi "https://doi.org/10.1136/bmj-2022-071281" @default.
• W4307888115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36316046" @default.
• W4307888115 hasPublicationYear "2022" @default.
• W4307888115 type Work @default.
• W4307888115 citedByCount "9" @default.
• W4307888115 countsByYear W43078881152022 @default.
• W4307888115 countsByYear W43078881152023 @default.
• W4307888115 crossrefType "journal-article" @default.
• W4307888115 hasAuthorship W4307888115A5005908129 @default.
• W4307888115 hasAuthorship W4307888115A5011554236 @default.
• W4307888115 hasAuthorship W4307888115A5013764429 @default.
• W4307888115 hasAuthorship W4307888115A5027248898 @default.
• W4307888115 hasAuthorship W4307888115A5044372933 @default.
• W4307888115 hasAuthorship W4307888115A5056759579 @default.
• W4307888115 hasAuthorship W4307888115A5060427520 @default.
• W4307888115 hasAuthorship W4307888115A5069596093 @default.
• W4307888115 hasAuthorship W4307888115A5070151669 @default.
• W4307888115 hasAuthorship W4307888115A5071306973 @default.
• W4307888115 hasAuthorship W4307888115A5072210649 @default.
• W4307888115 hasAuthorship W4307888115A5079198169 @default.
• W4307888115 hasAuthorship W4307888115A5079902505 @default.
• W4307888115 hasAuthorship W4307888115A5085526983 @default.
• W4307888115 hasAuthorship W4307888115A5085793081 @default.
• W4307888115 hasAuthorship W4307888115A5088259081 @default.
• W4307888115 hasAuthorship W4307888115A5088672135 @default.
• W4307888115 hasAuthorship W4307888115A5089233487 @default.
• W4307888115 hasBestOaLocation W43078881151 @default.
• W4307888115 hasConcept C126322002 @default.

• next