FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4307898127> ?p ?o ?g. }

• W4307898127 endingPage "102523" @default.
• W4307898127 startingPage "102523" @default.
• W4307898127 abstract "The recent rise in illicit use of methamphetamine (METH), a highly addictive psychostimulant, is a huge health care burden due to its central and peripheral toxic effects. Mounting clinical studies have noted that METH use in humans is associated with the development of cardiomyopathy; however, preclinical studies and animal models to dissect detailed molecular mechanisms of METH-associated cardiomyopathy development are scarce. The present study utilized a unique very long-access binge and crash procedure of METH self-administration to characterize the sequelae of pathological alterations that occur with METH-associated cardiomyopathy. Rats were allowed to intravenously self-administer METH for 96 h continuous weekly sessions over 8 weeks. Cardiac function, histochemistry, ultrastructure, and biochemical experiments were performed 24 h after the cessation of drug administration. Voluntary METH self-administration induced pathological cardiac remodeling as indicated by cardiomyocyte hypertrophy, myocyte disarray, interstitial and perivascular fibrosis accompanied by compromised cardiac systolic function. Ultrastructural examination and native gel electrophoresis revealed altered mitochondrial morphology and reduced mitochondrial oxidative phosphorylation (OXPHOS) supercomplexes (SCs) stability and assembly in METH exposed hearts. Redox-sensitive assays revealed significantly attenuated mitochondrial respiratory complex activities with a compensatory increase in pyruvate dehydrogenase (PDH) activity reminiscent of metabolic remodeling. Increased autophagy flux and increased mitochondrial antioxidant protein level was observed in METH exposed heart. Treatment with mitoTEMPO reduced the autophagy level indicating the involvement of mitochondrial dysfunction in the adaptive activation of autophagy in METH exposed hearts. Altogether, we have reported a novel METH-associated cardiomyopathy model using voluntary drug seeking behavior. Our studies indicated that METH self-administration profoundly affects mitochondrial ultrastructure, OXPHOS SCs assembly and redox activity accompanied by increased PDH activity that may underlie observed cardiac dysfunction." @default.
• W4307898127 created "2022-11-06" @default.
• W4307898127 creator A5006835294 @default.
• W4307898127 creator A5007285376 @default.
• W4307898127 creator A5009347189 @default.
• W4307898127 creator A5013485864 @default.
• W4307898127 creator A5014483271 @default.
• W4307898127 creator A5024682299 @default.
• W4307898127 creator A5026224699 @default.
• W4307898127 creator A5028503496 @default.
• W4307898127 creator A5033947768 @default.
• W4307898127 creator A5044954505 @default.
• W4307898127 creator A5051378415 @default.
• W4307898127 creator A5062358062 @default.
• W4307898127 creator A5067696537 @default.
• W4307898127 creator A5087345721 @default.
• W4307898127 creator A5087689042 @default.
• W4307898127 date "2022-12-01" @default.
• W4307898127 modified "2023-10-13" @default.
• W4307898127 title "Mitochondrial dysfunction and autophagy activation are associated with cardiomyopathy developed by extended methamphetamine self-administration in rats" @default.
• W4307898127 cites W1872082862 @default.
• W4307898127 cites W1882356554 @default.
• W4307898127 cites W1938218641 @default.
• W4307898127 cites W1964155766 @default.
• W4307898127 cites W1968048495 @default.
• W4307898127 cites W1974560134 @default.
• W4307898127 cites W2007560339 @default.
• W4307898127 cites W2008287879 @default.
• W4307898127 cites W2013082697 @default.
• W4307898127 cites W2029788846 @default.
• W4307898127 cites W2051476652 @default.
• W4307898127 cites W2052464626 @default.
• W4307898127 cites W2053372974 @default.
• W4307898127 cites W2054780791 @default.
• W4307898127 cites W2055560694 @default.
• W4307898127 cites W2055971882 @default.
• W4307898127 cites W2058617199 @default.
• W4307898127 cites W2065712257 @default.
• W4307898127 cites W2071691507 @default.
• W4307898127 cites W2082231490 @default.
• W4307898127 cites W2082962210 @default.
• W4307898127 cites W2084059600 @default.
• W4307898127 cites W2088417711 @default.
• W4307898127 cites W2090913071 @default.
• W4307898127 cites W2091509954 @default.
• W4307898127 cites W2101025145 @default.
• W4307898127 cites W2104215888 @default.
• W4307898127 cites W2109659566 @default.
• W4307898127 cites W2112125919 @default.
• W4307898127 cites W2116101915 @default.
• W4307898127 cites W2135581873 @default.
• W4307898127 cites W2143588920 @default.
• W4307898127 cites W2144916780 @default.
• W4307898127 cites W2165274786 @default.
• W4307898127 cites W2166166971 @default.
• W4307898127 cites W2168471301 @default.
• W4307898127 cites W2175271030 @default.
• W4307898127 cites W2269169020 @default.
• W4307898127 cites W2305533673 @default.
• W4307898127 cites W2305670323 @default.
• W4307898127 cites W2321270707 @default.
• W4307898127 cites W2404705422 @default.
• W4307898127 cites W2478776332 @default.
• W4307898127 cites W2585450556 @default.
• W4307898127 cites W2592965340 @default.
• W4307898127 cites W2619579629 @default.
• W4307898127 cites W2732680111 @default.
• W4307898127 cites W2741060213 @default.
• W4307898127 cites W2763897668 @default.
• W4307898127 cites W2782047940 @default.
• W4307898127 cites W2790424921 @default.
• W4307898127 cites W2840219085 @default.
• W4307898127 cites W2887191177 @default.
• W4307898127 cites W2895936122 @default.
• W4307898127 cites W2912308947 @default.
• W4307898127 cites W2913052335 @default.
• W4307898127 cites W2913126549 @default.
• W4307898127 cites W2913175155 @default.
• W4307898127 cites W2969628213 @default.
• W4307898127 cites W2970868355 @default.
• W4307898127 cites W2979405948 @default.
• W4307898127 cites W2989647509 @default.
• W4307898127 cites W3017123791 @default.
• W4307898127 cites W3032165534 @default.
• W4307898127 cites W3044049566 @default.
• W4307898127 cites W3091676513 @default.
• W4307898127 cites W3096995764 @default.
• W4307898127 cites W3101705429 @default.
• W4307898127 cites W3104848430 @default.
• W4307898127 cites W3108936441 @default.
• W4307898127 cites W3112963898 @default.
• W4307898127 cites W3130069565 @default.
• W4307898127 cites W3135245997 @default.
• W4307898127 cites W3164094161 @default.
• W4307898127 cites W3179774457 @default.
• W4307898127 cites W3188864108 @default.
• W4307898127 cites W3196346144 @default.
• W4307898127 cites W3199254314 @default.

• next